1998 Fiscal Year Final Research Report Summary
Molecular mechanism of synaptic plasticity
| Project/Area Number |
07278103
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Research Institution | The University of Tokyo |
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Principal Investigator |
SHIMIZU Takao UNIVERSITY OF TOKYO, GRADUATh SCHOOL OF MIEDICINE, PROFESSOR, 大学院・医学系研究科, 教授 (80127092)
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| Co-Investigator(Kenkyū-buntansha) |
SHIBUKI Katsuei NIIGATA UNIVERSITY, INSTITUTE OF BRAIN RESEARCH, PROFESSOR, 脳研究所, 教授 (40146163)
KAIBUCHI Kozo Nara INSTLTUTE OF SCIENCE and TECHNOLOGY,DEPARTMENT OF CELL-BIOLOGY, PROFESSOR, バイオサイエンス研究科, 教授 (00169377)
KASAI Haruo Okazaki, NATIONAL INSTITUTh OF PHYSIOLOGICAL SCIENCES, PROFESSOR, 生理学研究所, 教授 (60224375)
KUDO Ichoro SHOWA UNIVERSITY, FACULTY OF PHARMACEUTICAL SCIENCES, PROFESSOR, 薬学部, 教授 (30134612)
MIYAZAKI Jyunichi OSAKA UNIVERSITY, SCHOOL OF MIEDICINE, PROFESSOR, 大学院・医学研究科, 教授 (10200156)
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| Project Period (FY) |
1995 – 1998
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| Keywords | lipid mediators / protein kinase C / phospholipases |
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| Research Abstract |
Various enzymes and receptors for lipid niediators (prostaglandins, leukotrines, platelet-activating factor etc.) have been isolated and their knockout mice were established by the members of this project. By analyzing their phenotypes, it was found that these mediators arc involved in brain functions, synaptogeneses, and neuronal cell development, working in concert with glutamate and other neurotransmitters. we also identified regulations of various types of kinases (protein kinases C, calcium calmodulin-dependent kinases, MAP kinases etc) during synaptic transmission and plasticity. Several small sized GTP binding proteins, and related molecules (SNARE, CREB) are identified of their roles in the synaptic plasticity.
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