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1998 Fiscal Year Final Research Report Summary

Molecular mechanism of synaptic plasticity

Research Project

Project/Area Number 07278103
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Research InstitutionThe University of Tokyo

Principal Investigator

SHIMIZU Takao  UNIVERSITY OF TOKYO, GRADUATh SCHOOL OF MIEDICINE, PROFESSOR, 大学院・医学系研究科, 教授 (80127092)

Co-Investigator(Kenkyū-buntansha) SHIBUKI Katsuei  NIIGATA UNIVERSITY, INSTITUTE OF BRAIN RESEARCH, PROFESSOR, 脳研究所, 教授 (40146163)
KAIBUCHI Kozo  Nara INSTLTUTE OF SCIENCE and TECHNOLOGY,DEPARTMENT OF CELL-BIOLOGY, PROFESSOR, バイオサイエンス研究科, 教授 (00169377)
KASAI Haruo  Okazaki, NATIONAL INSTITUTh OF PHYSIOLOGICAL SCIENCES, PROFESSOR, 生理学研究所, 教授 (60224375)
KUDO Ichoro  SHOWA UNIVERSITY, FACULTY OF PHARMACEUTICAL SCIENCES, PROFESSOR, 薬学部, 教授 (30134612)
MIYAZAKI Jyunichi  OSAKA UNIVERSITY, SCHOOL OF MIEDICINE, PROFESSOR, 大学院・医学研究科, 教授 (10200156)
Project Period (FY) 1995 – 1998
Keywordslipid mediators / protein kinase C / phospholipases
Research Abstract

Various enzymes and receptors for lipid niediators (prostaglandins, leukotrines, platelet-activating factor etc.) have been isolated and their knockout mice were established by the members of this project. By analyzing their phenotypes, it was found that these mediators arc involved in brain functions, synaptogeneses, and neuronal cell development, working in concert with glutamate and other neurotransmitters. we also identified regulations of various types of kinases (protein kinases C, calcium calmodulin-dependent kinases, MAP kinases etc) during synaptic transmission and plasticity. Several small sized GTP binding proteins, and related molecules (SNARE, CREB) are identified of their roles in the synaptic plasticity.

  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] Kimura, K. et al.: "Regulation of myosin phosphorylation by Rho and Rho-associated kinase(Rho-Kinase)"Science. 273. 245-248 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ho, YS et al.: "Brain acetylhydrolase that inactivates platelet-activating factor (PAF) is a G-protein-like trimer"Nature. 385. 89-93 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yokomizo, T. et al.: "A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis"Nature. 387. 620-624 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ushikubi, F. et al.: "Impaired febrile response in mice lacking the prostaglandin E receptor subtype EP^3"Nature. 395. 281-284 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Okuda-Ashitaka, E.: "Nocistatin : a peptide blocking nociceptin action in pain transmission"Nature. 392. 286-289 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kasai, H. et al.: "Multiple and diverse forms of regulates exocytosis revealed in wild-type and defective PC12 cells"Proc. Natl. Acad. Sci. U.S.A.. 96. 945-949 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kimura, K. et al.: "Regulation of myosin phosphorylation by Rho and Rho-associated kinase (Rho-kinase)"Science. 273. 245-248 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ho, YS et al.: "Brain acetyihydrolase that inactivates platelet-activating factor (PAF) is a G-protein-like trimer"Nature. 385. 89-93 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yokomizo, T. et al.: "A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis"Nature. 387. 620-624 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ushikubi, F. et al.: "Impaired febrile response in mice lacking the prostaglandin E receptor subypte EP3"Nature. 395. 281-284 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Okuda-Ashitaka, E. et al.: "Nocistatin : a peptide blocking nociceptin action in pain transmissioin"Nature. 392. 286-289 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kasai, H. et al.: "Multiple and diverse forms of regulates exocytosis revealed in wild-type and defective PC12 cells"Proc. Nati. Acad. Sci. U.S.A. 96. 945-949 (1999)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2001-10-23  

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