| Co-Investigator(Kenkyū-buntansha) |
NIWA Osami Kazusa DNA Research Institute, Chief Investigato, 室長 (70144318)
NISHINOTO Takeharu Kyusyu University, Graduate School of Meidical Science, Professor, 大学院・医学系研究科, 教授 (10037426)
KOMINAMI Ryou Nilgata University. School of Medicine, Professor, 医学部, 教授 (40133615)
YANAGIDA Mitsuhiro Tohoku University, Graduate School of Agricultural Science, professor, 大学院・理学研究科, 教授 (80025428)
HIROSE Susumu National Institute of Genetics Department of Developmental Genetics, Professor, 教授 (90022730)
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| Research Abstract |
The major purpose of this research group was to organize, plan and evaluate the joint research project "Functional Structure of Cell Nucleus : Molecular Constitution and Intermolecular Communications" supported by Grant-in-Aid for Scientific Research on Priority Areas (A) (1) during the period of 1995 to 1998. This group also organized joint research conferences, public symposia and workshops on chromosomes in association with the above joint research project. In 1999, this group worked on publication of a report of the joint research which consisted of review papers (332 pages) written by 38 members ; each review included own research results and related progress in the world. The above joint research was the first one which aimed at understanding the molecular structure and function of the cell nucleus. It consisted of three programmed research groups ; 1) Intranuclear distribution of chromosomes and its cause, 2) Constitution of the sites for excecution of nuclear functions, and 3) Molecular communication between cytoplasm and nucleus, including 19 scientists. In addition, altogether 49 individual research members aiming at related subjects were selected to join. Research subjects included ; heterochromatin, telomere, centromere, synapsis and recombination between homologous chromosomes in meiosis, spindle pole body, chromatin remodeling and transcriptional control, locus control region, genomic imprinting, nuclear lamina and association of chromatin, nuclear pore complex, apoptosis and chromatin fragmentation, RNA export from the nucleus, degradation and reassembly of nuclear membrane during mitosis. The common key word of the entire study was the protein molecular complex in the nuclus : its constitution, function and regulation.
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