1998 Fiscal Year Final Research Report Summary
Molecular Mechanisms for the Establishment of Germ Cells and Their Commitment to Meiosis
| Project/Area Number |
07283101
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas (A)
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| Allocation Type | Single-year Grants |
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| Research Institution | The University of Tokyo |
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Principal Investigator |
YAMAMOTO Masayuki Graduate School of Science, Professor, 大学院・理学系研究科, 教授 (40114706)
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| Co-Investigator(Kenkyū-buntansha) |
SAGATA Noriyuki Kyushu University, Graduate School of Science, Professor, 大学院・理学研究科, 教授 (80142024)
ABE Shinichi Kumamoto University, Graduate School of Science and Technology, Professor, 大学院・自然科学研究科, 教授 (90109637)
NAGAHAMA Yoshitaka Okazaki National Research Institutes, National Institute for Basic Biology, 基礎生物学研究所, 教授 (50113428)
MOHRI Hideo Okazaki National Research Institutes, National Institute for Basic Biology, Director, 基礎生物学研究所, 所長(研究職) (70012268)
TOYOSHIMA Kumao Institute of Medical Science, Emeritus Professor, 医科学研究所, 名誉教授 (90029760)
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| Project Period (FY) |
1995 – 1999
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| Keywords | germ cell / meiosis / cell cycle / RNA-binding protein / University and Science |
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| Research Abstract |
This research project, termed "Molecular Mechanisms for the Establishment of Germ Cells and Their Commitment to Meiosis", has been supported by a Grant-in-Aid for Scientific Research on Priority Areas (A) from the Ministry of Education, Science, Sports and Cultures of Japan. From April 1995 through March 1999, two project teams carried out concentrated research in this Priority Area on two topics, i.e., "Molecular Mechanisms of Germ Cell Formation" and "Characteristics and Regulation of Meiosis". The mission of this research project was to supervise and assist the two teams so that they may fulfill their research effectively, to publicize important results which they obtained, and thus to promote the research in this Priority Area in Japan. A large mass of new knowledge has been brought consequently by the two teams. Notably, they clarified that RNA-binding proteins play key roles in both germ cell development and regulation of meiosis. They also elucidated the molecular mechanisms which differentiate the meiotic cell cycle from the mitotic one. During the last four years, this project summarized progress of the research and edited a report booklet annually. To conclude the four-year research in the fiscal year 1999, this project has edited a voluminous book which includes reports of all individual members and their major publications. In addition, supported also by a Grant-in-Aid for Publication of Scientific Research Results, we presented a two-day session entitled "Germ Cells : Their Origin and Behavior" in the 14th "University and Science" Symposium, which was open for public
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[Publications] Tokumoto, T., Yamashita, M., Tokumoto, M. Katsu, Y., Horiguchi, R, Kajiura, H. and Nagahama, Y: "Initiation of cyclin B degradation by the 26S proteasome upon egg activation"Journal of Cell Biology. 138. 1313-1322 (1997)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Nakajo, N., Yoshitome, S., Iwashita, J., Iida, M., Uto, K., Ueno, S., Okamoto, K. and Sagata, N.: "Absence of Weel ensures the meiotic cell cycle in Xenopus oocytes"Genes & Development. 14. 328-338 (2000)
Description
「研究成果報告書概要(欧文)」より
