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1997 Fiscal Year Final Research Report Summary

Cohort Study on Management System for Periodontal Maintenance Patients.

Research Project

Project/Area Number 07307020
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Conservative dentistry
Research InstitutionShowa University

Principal Investigator

HASEGAWA Kohji  Showa Univ.Dent.Sch., Professor, 歯学部, 教授 (70014024)

Co-Investigator(Kenkyū-buntansha) SUZUKI Joichiro  Tsurumi Univ., Sch.Dent.Med., Assistant, 歯学部, 助手 (10187734)
MURAKAMI Shinya  Osaka Univ., Faculty Dent., Lecturer, 歯学部, 講師 (70239490)
ISHIKAWA Isao  Tokyo Med.& Dent.Univ., Professor, 歯学部, 教授 (10014151)
WATANABE Tatsuo  Okayama Univ.Dent.Sch., Preofessor, 歯学部, 教授 (20034176)
MURAYAMA Yoji  Okayama Univ.Dent.Sch., Professor, 歯学部, 教授 (50029972)
Project Period (FY) 1995 – 1997
Keywordslongtudinal study / maintenancelevel / cohort study / antibody titer / number of Missing tooth / Periodontopathic bacteria / host factor
Research Abstract

[Assessment of long term results after periodontal treatment]
SUZUKI observed post treatment changes during maintenance period in 68 periodontal patients, and indicated that periodontal pocket keep their original depth in well maintenained group, however in down hill group recurrence of periodontal pathosis resulting in retreatment of tooth extraction occurred 32 months after treatment. KUMAGAYA surveyed post treatment changes in 208 patients. The relationships were not found between initial plaque score and post treatment results, which means host factor might be more important than parasite factor in maintenance patients.
[Analysis of host factor]
ISHIKAWA reported that patients who have higher antibodies to both Actinobacillus actinomycetemcomitance and porphylomonas gingivalis showed poorer post treatment results than others. MURAYAMA confirmed ISHIKAWA's observation, and suggested further that chemotactic and phagocytotic activities, total T cell number, Th/I ratio would be regarded as risk indicators for the further progression of periodontal diseases. MURAKAMI extracted high risk group which showed at least 4% further alveolar bone resorption on the X-ray pictures during 5 years from maintenance patiehts. The high risk patients exhibited significantly higher IL-l concentration in Gingival Crevicular Fluid, higher concentration of P.gingivalis in the subgingival plaque, and higher antibody titer to P.g.
[Risk indicator after active periodontal treatment]
HASEGAWA used a bacterial monitoring kit to detect specific enzyme for periodontopahtic bacteria such as P.g.and Treponema denticola, and concluded that this system was extremely useful in monitoring post-treatment effect. This result coincide to MURAKAMI's finding. WATANABE suggested to employ tow defferent concept in risk indicator, stage marker and state marker. Attachment level should be regarded as a stage marker and probing pocket depth as a state marker.

  • Research Products

    (15 results)

All Other

All Publications (15 results)

  • [Publications] Yamamoto M, Nishihara T, Koseki T, et al.: "Prevalence of Actinobacillus actinomycetemcomitans in Japanese patients with periodontitis." Journal of Periodontal Research. 32. 676-681 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 村上 伸也、岡田 宏: "歯周病の分子生物学的診断." 日本歯科医学会誌. 16. 6-13 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kojima T, Yano K and Ishikawa I: "Relationship between serum antibody levels and subgingival colonization of Porphyromonas gingivalis in patients with various types of periodontitis." Journal of Periodontology. 68. 615-625 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ishikawa I, Nakashima K, Koseki T, et al.: "Induction of the immune response to periodontopathic bacteria and its role in the pathogenesis of periodontitis." Periodontology 2000. 14. 79-111 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 鈴木 丈一郎, 他: "歯周疾患患者のメインテナンス期におけるプラークコントロールを併用したバス法とのマッサージ効果の比較." 日本歯科保存学雑誌. 40. 198-204 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ishikawa I, et al.: "Detection of refractory periodontal patients by means of ELISA method." Risk Factors in Asian Pacific Populations. 83-91 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ishikawa I, et al.: "Proceeding of the Asian Pacific Society of Periodontology Meeting Australia 1995." Detection of refractory periodontal patients by means of the ELISA method. In ; Bartold PM ed. Risk Factors in Asian Pacific Populations, (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yamamoto M,Nishihara T,Koseki T,He T,Yamato K,Zhang YJ,Nakashima K,Oda S,Ishikawa I: "Prevalence of Actinovacillus actinomycetemcomitance in Japanese patients with periodontitis." J Periodontal Research. 32. 676-681 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kojima T,Yano K and Ishikawa I: "Relationship between serum antibody levels and subgi gival colonization of Porphylomonas gingivalis in patients with various types of periodontitis." J Periodontol.68. 618-625 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ishikawa I,Nakashima K,Koseki T,Nagasawa T,Watanabe H,Arakawa S,Nitta H and Nishihara T: "Induction of the immune response to periodontopathic bacteria and its role in the pathogenesis of periodontitis." Periodontology 2000. 14. 79-111 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Suzuki J,Fujii N,Yamaguchi H,Watanabe I,Gomi K,Watanabe T: "Relationship between the plaque control level and the other clinical findings in maintenance phase in the patients with periodontal disease" Japan J Conserv Dent. 40. 197-203 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Murakami S and Okada H: "Diagnosis of periodontal disease based on the techniques of molecular biology" J Japan Assoc Dent Science. 16. 6-13 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ishikawa I,et al.: "Detection of refractory periodontal patients by means of ELISA method" Risk factors in Asian Pacific Populations. 83-91 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Okada H,Murakami S,et al.: "Diagnostic strategies of periodontitis based on the molecular mechanisms of periodontal tissue destruction." Oral Deseases. 2. 87-95 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ishikawa I,et al.: Detection fo refractory periodontal patients by means of an ELISA method. In : Bartold PM ed.Risk Factors in Asian Pacific Populations.Proceedings of the Asian Pacific Society of Periodontology.,

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-03-16  

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