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1996 Fiscal Year Final Research Report Summary

EVALUATION OF THE MUTAGENICITY IN THE ENVIRONMENTAL WATER

Research Project

Project/Area Number 07308041
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section総合
Research Field Environmental dynamic analysis
Research InstitutionOKAYAMA UNIVERSITY

Principal Investigator

HAYATSU Hikoya  OKAYAMA UNIVERSITY,FACULTY OF PHARMACEUTICAL SCIENCES,PROFESSOR, 薬学部, 教授 (10012593)

Co-Investigator(Kenkyū-buntansha) HORIKAWA Kazumi  FUKUOKA HEALTH AND ENVIRONMENTAL RESEARCH CENTER,RESEARCHER, 保健科学部, 専門研究員
NOGAMI Yusaku  OKAYAMA UNIVERSITY OF SCIENCES,FACULTY OF SCIENCES,PROFESSOR, 理学部, 教授 (00172768)
NAKAMURO Katsuhiko  SETSUNAN UNIVERSITY,FACULTY OF PHARMACEUTICAL SCIENCES,PROFESSOR, 薬学部, 教授 (30172464)
KIRA Shohei  OKAYAMA UNIVERSITY,FACULTY OF MEDICAL SCIENCES,LECTURER, 医学部, 講師 (50033212)
UTSUMI Hideo  KYUSHU UNIVERSITY,FACULTY OF PHARMACEUTICAL SCIENCES,PROFESSOR, 薬学部, 教授 (20101694)
Project Period (FY) 1995 – 1996
KeywordsADSORBENT FOR MUTAGEN / BLUE CHITIN COLUMN / CARCINOGENS IN ENVIRONMENTAL WATER / BIOLOGICAL MONITORING / ENVIRONMENTAL POLLUTION / 健康影響 / 生物学的環境モニタリング / 環境汚染
Research Abstract

Using the blue chitin column technique, mutagens in the water of two rivers (Katsura river in Kyoto, and Asahi river in Okayama), were monitored. The results were compared with these found by already available method, the XAD-2 resin concentration technique. As a result, the blue chitin method proved to be 2 times more efficient in concentrating the mutagens. The blue rayon hanging technique was used to monitor mutagens in lakes in the Fukuoka area and the results showed that the lakes that showed no high COD values gave positive mutagenic responses. In conclusion, the blue chitin column and blue rayon hanging methods have been firmly established as techniques for monitoring mutagens in the environmental waters.

  • Research Products

    (20 results)

All Other

All Publications (20 results)

  • [Publications] 早津彦哉: "A short-column technique for concentrating mutagens/carcinogens having polycyclic structures" Analytical Biochemistry. 235. 185-190 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 内海英雄: "Application of micronucleus in vitro assay to micropollutants in river water" Water Science and Technology. (in press). (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 堀川和美: "Evaluation of mutagenicity of complex mixture of nitroarenes using mouse micronuclei test" J.Toxicological & Environmental Chemistry. 54. 161-165 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 阪本博: "Evaluation of blue-chitin columm,blue-rayon hanging,and XAD-resin column techniques for concentrating mutagens from two Japanese rivers" Mutation Res.371. 79-85 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 吉良尚平、野上祐作、早津彦哉: "A simple technique for monitaring mutagenicity and benzo (a) pyrene content in mussels and their ambient water" Environ.Toxicol.Water Qual.10. 167-172 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 中室克彦: "Disinfection by-products in the chlorination of organic nitrogen compounds : By-products from kynurenine" Chemoshere. 33. 1425-1433 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Kira, Taketa, T.Nogami, H.Hayatsu: "A simple technique for monitaring mutagenicity and benzo (a) pyrene content in mussels and their ambient water." Environ.Toxicol.Water Qual.10. 167-172 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H.Hayatsu, T.Hayatsu, S.Arimoto and H.Sakamoto: "A short-column technique for concentrating mutagens/carcinogens having polycyclic structures." Analytical Biochemistry. 235. 185-190 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S.Kira, Y.Nogami, K.Taketa, and H.Hayatsu: "Comparison of techniques for monitoring water-borne polycyclic mutagens : efficiency of blue rayon, Sep-Pak C18, and a biota, Corbicula, in concentrating benzo (a) pyrene in a model water system." Bull.Environ.Contam.Toxicol.57. 278-283 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H.Hayatsu, H.Sakamoto, S.Kira and Y.Nogami: "Monitoring of water-borne polycyclic mutagens." PAEMS Proceedings Supplement of the African Newsletter on Occupational Health and Safety. 6. 14-18 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H.Hayatsu, T.Kubo, Y.Tanaka and K.Negishi: "Polynucleotide-Chitosan Complex : Preparation, properties and applications." Nucleic Acid Symposium Series. 35. 253-254 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.Mure, H.Hayatsu, T,Takeuchi T.Takeshita and K.Morimoto: "Heavy cigarette smokers show higher mutagenicity in urine." Mutation Res.(in press). (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H.Sakamoto, T.Ohe, T.Hayatsu and H.Hayatsu: "Evaluation of blue-chitin column, blue-rayon hanging, and XAD-resin column techniques for concentrating mutagens from two Japanese reivers." Mutation Res.371. 79-85 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H.Hayatsu, Y.Tanaka and T.Hayatsu: "Non-covalent binding of carcinogenic heterocyclic amines to polynucleotides." Collet.Czech.Chem.Commun.Special Issue. 61. 250-252 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S.Kira, Y.Nogami, T.Ito and H.Hayatsu: "Detection of benzo (a) pyrene and mutagenicity in water of Lake Baikal (Russia) and of rivers in Okayama (Japan) using the blue rayon method : a simplified handling and transportation of samples from remote sites." Environ.Toxicol.Water Qual.(submitted).

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H.Ueno, T.Moto, Y.Sayato, K.Nakamuro: "Disinfection by-products in the chlorination of organic nitrogen compounds : By-products from kynurenine." Chemoshere. 33. 1425-1433 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.Murakami, N.Sera and K.Horikawa: "Evaluation of mutagenicity of complex mixture of nitroarenes using mouse micronuclei test." The Journal of Toxicological and Environmental Chemistry. 54. 161-165 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.Horikawa, N.Sera, K.Murakami, N.Sano, K.Izumi and H.Tokiwa: "Mutagenicity and tumorigenicity of 1- and 3- nitrobenzo (a) pyrene and 3,6- and 1,6-dinitrobenzo (a) pyrene and related compounds." Carcinogenesis. (in press). (1977)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Y.-S.Chung, K.Ichikawa and H.Utsumi: "Application of micronucleus in vitro assay to micropollutants in river water." Water Sciences and Technology. (in press). (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H.Hayatsu: Complex formation of heterocyclic amines with porphyrins ; its use in detection and prevention. Heterocyclic Amines in Cooked Food : Possible Human Carcinogens, eds.by R.H.Adamson, J-A.Gustafsson, N.Ito, M.Nagao, T.Sugimura, K.Wakabayashi and Y.Yamazoe.Princeton Press, New Jersey, 172-180 (1995)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-03-09  

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