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1996 Fiscal Year Final Research Report Summary

Analysis of Morphogenesis and Differentiation of Dictyostellium by restriction enzyme mediated insertion (REMI)

Research Project

Project/Area Number 07308052
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section総合
Research Field Developmental biology
Research InstitutionOkazaki National Research Institutes

Principal Investigator

TAKEUCHI Ikuo  Okazaki Nat.Res.Ins., President, 機構長 (90025239)

Co-Investigator(Kenkyū-buntansha) MAEDA Mineko  Osaka Univ.Grad.Sch.Sci., Res.Assoc., 大学院・理学研究科, 助手 (70029700)
TANAKA Yoshimasa  Tsukuba Univ.Inst.Biol.Sci., Prof., 生物科学系, 教授 (80091908)
MAEDA Yasuo  Tohoku Univ., Grad.Sch.Sci., Prof., 大学院・理学研究科, 教授 (50025417)
OCHIAI Hiroshi  Hokkaido Univ., Grad.Sch.Sci., Prof., 大学院・理学研究科, 教授 (10002122)
SUTO Kazuo  Univ.Tokyo, Coll.Arts & Sci., Asso.Prof., 教養学部, 助教授 (20111453)
Project Period (FY) 1995 – 1996
KeywordsCellular slime mold / Insertion mutagenesis / Genetic engineering / Morphogenesis / Development / Differentiation / Dictyostelium / Signal transduction
Research Abstract

Takeuchi, I.organized Dictyostelium cDNA project with several members of this research group and started in the last autumn. He also found that prestalk and prespore cells sucked into a capillary tube do not differentiate at a constant propotion, as in ordinary slugs.
Molecular mechanism of morphogenesis Suto, K.analyzed a REMI mutant which dose not develop after aggregation, and found that the mutated genes is a homologue of SSN6 gene of yeast. Ochiai, H.prepared rabbit polyclonal antibody raised against the membrance fraction isolated from Polysphondylium cells transformed with an antisence RNA-expressing plasmid to reduce cell-adhesion protein. As the antibody efficiently inhibits Polysphondylium cell-adhesion, it will be a good tool to analyze the mechanism in the formation of multeicellular structure of the organism. Molecular machanism of differentiation To investigate a switch mechanism from growth to differentiation, Maeda, Y.cloned two genes (Quit2,3) which are expressed around the critical point (PS point) of the cell cycle. He found that Quit2 encodes a new calcium-binding protein and Quit3 has a sequence coding for the complementary strand of annexin Vll gene. Oohata, A.isolated a factor induction of prespore differentiation in vitro. Maeda, M.revealed that the gene is essential for aggregation and that hetero-trimeric G proteins are not required for this regulation. Tanaka, Y.established the techniques for an insertional mutagenesis with Polysphondylium cells by the use of REMI method. Ishida, S.isolated 'sporogenous mutant', in which even single cells differentiate into spores and tag mutants which stop at the 'tight aggregate' stage. Urushihara, H.analyzed two sorts of REMI mutants (TMC1 and MCF1). TMC1 was normal for sexual cell fusion, but was unusual for chemotaxis. MCF1 had a defect in sexual cell fusion.

  • Research Products

    (75 results)

All Other

All Publications (75 results)

  • [Publications] Yumura,S.: "Intracellular free calcium responses during chemotaxis of Dictyostelium cells" J. Cell Sci.109. 2673-2678 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Saito,T.: "Identification of a novel all-cis-5,9,12 heptadecatrienoic acid in the cellular slime mold Polysphondylium pallidum" Lipids,. 31. 445-447 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Funamoto,S.: "Antisence RNA inactivation of gene expression of a cell-cell adhesion protein (gp64) in the celluar slime mold Polysphondylium palidum" J.Cell.Sci.109. 1009-1010 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Fukuzawa,M.: "Molecular cloning and characterization of the cDNA for Discoidin II of Dictyostelium discoideum" Plant Cell Physiol.37. 505-514 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ochiai,H.: "Dimer formation of a cell-cell adhesion protein,gp64 of the cellular slime mold,Polysphondylium pallidum" Plant Cell Physiol. 37. 135-139 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nakata,N.: "Inhibitory Effects of Tunicamycin on Cell Cell Adhesion and Cell Reaggregation of the Cellular Slime Mold,Polysphondylium pallidum." J.Plant Res.109. 193-199 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Amagai,A.: "Dictyostelium mucoroides cells exhibit cell cycle-dependent sorting behavior as observed in D. discoideum dvelopment" Dev.Growth & Differ.38. 33-40 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Maeda,M.: "Seven helix chemoattractant receptors transiently stimulate mitogenactivated protein kinase in Dictyostelium" J. Biol. Chem.271. 3351-3354 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yamaguchi,N.: "Targeted disruotion of genes for gp138,a cell-fusion-related protein in Dictyostelium discoideum,revealed the existence of a third gene." Dev.Growth & Differ.38. 271-279 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Pi,M.: "Analysis of a tRNA gene-like sequence (t-element) with TTA at the anticodon position in the mitochondrial DNA of Dictyostelium discoideum." J.Plant Res.109. 1-6 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Urushihara,H.: "Protease-sensitive component (s) on cell surface prevents self-fusion in a bisexual strain of Dictyostelium discoideum." Cell Struct.Funct.21. 41-46 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Urushihara,H.: "Choice of partners : Sexual cell interactions in Dictyostelium discoideum" Cell Struct.Funct.21. 231-236 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kuwayama,H.: "Aberrant cGMP-binding activity in non-chemotactic Dictyostelium discoideum mutants." Biochim. Biphys. Acta. 1268. 214-217 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Oyama,M.: "cGMP accumulation induced by hypertonic stress in Dictyostelium discoideum." J.Biol.Chem.271. 5574-5579 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yumura,S.: "Rapid redistribution of myosin II in living Dictyostelium amoebae,as revealed by fluorescent probes introduced by electroporation." Protoplasma. 192. 217-227 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yumura,S.: "Spatial distribution of fluorescently labeled actin in living Dictyostelium amoebae" Cell Struct.Funct.21. 189-197 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yumura,S.: "Myosin II can be localized to the cleavage furrow and to the posterior region of Dictyostelium amoebae without control by phosphorylation of myosin heavy and light chains." Cell Motil.Cytoskel.(in press). (1977)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Fujita,H.: "Characterization of mutant myosins equivalent to human familial hypertophic cardiomyopathy mutants." J.Clinc.Invest.(in press). (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Arakane,T.: "Relevance of histone H1 kinase activity to the G2/M transition during the cell cycle of Dictyostelium discoideum." J.Plant Res.(in press). (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Okafuji,T.: "Antisense-mediated regulation of Annexin VII gene expression during the transition from growth to differentiation in Dictyostelium discoideum." Gene. (in press). (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Aubry,L.: "The Dictyostelium MAP kinase ERK2 is regulated by Ras and cAMP-dependent protein kinase (PKA) and mediates PKA function." J.Biol.Chem.(in press). (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ogawa,S.: "A site-specific DNA endonuclease specified by one of two ORFs encoded by a group I intron in Dictyostelium discoideum mitochondrial DNA." Gene. (in press). (1977)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Komori,K.: "Localization of a DNA topoisomerase II to mitochondria in Dictyostelium discoideum : deletion mutant analysis and mitochondrial targeting signal presequence." J.Plant Res.(1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Komori,K.: "Cloning and characterization of the gene encoding a mitochondrially localized DNA topoisomerase II in Dictyostelium discoideum : Western blot analysis." Biochim. Biophys. Acta. (in press). (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Aiba,K.: "Isoforms of gp138,a cell-fusion related protein in Dictyostelium discoideum." J.Biochem.(in press). (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ogawa,S.: "Group I introns in the cytochrome oxidase genes of Dictyostelium discoideum : two related ORFsin one loop of a group I intron,a cox 1/2 hybrid gene and an unusually large cox3 gene." Curr.Genet.(in press). (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Shimizu,H.: "A mutation in the cAMP signaling pathway affects sexual development of Dictyostelium discoideum." Dev.Growth & Differ.(in press). (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 雨貝愛子: "図解生物科学講座3:発生生物学(浅島誠 編著)" 朝倉書店,東京, 250 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Fisher, A.J., Smith, C.A., Thoden, J., Smith, R., Sutoh, K., Holden, H.M.and Rayment, I.: "Structures of Beryllium and Aluminium metallofluoride-Mg-ADP complexes of the Dictyostelium discoideum myosin motor domain." Biochemistry. 34. 8960-8972 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fisher, A.J., Smith, C.A., Sutoh, K., Holden, H.M.and Rayment, I.: "The preliminary structure of the ATP-bound state of myosin." Biophys.J.68. 19s-28s (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Aizawa, H., Sutoh, K., Tsubaki, S., Kawashima, S., Ishii, A.and Yahara, I.: "Identification, characterization, and intracellular distribution of cofilin in Dictyostelium discoideum." J.Biol.Chem.270. 10923-10932 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ochiai, H., Saito, T., Funamoto, S., Fukuzawa, M., Nakata, N., Kizimoto, S.and Arisaka, F.: "Effects of Tunicamycin on the development of Dictyostelium discoideum." Animal Biology. 4. 3-11 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Matsuyama, S.and Maeda, Y.: "Involvement of cyanide-resistant respiration in cell-type proportioning during the Dictyostelium development." Dev.Biol.172. 182-191 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Araki, T.and Maeda, Y.: "Cell-cycle progression during the development of Dictyostelium discoideum and its relation to the subsequent cell-sorting in multicellular structures." Dev.Growth & Differ.37. 39-48 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Iijima, N., Takagi, T.and Maeda, Y.: "A proteinous factor mediating intercellular communication during the transition of Dictyostelium cells from growth to differentiation." Zoolog.Sci.12. 61-69 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Abe, F.and Maeda, Y.: "Specific expression of a gene encoding a novel calcium-binding protein, CAF-1, during transition of Dictyostelium cells from growth to differetiation." Dev.Growth & Differ.37. 39-48 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Segall, J., Kuspa, A., Shaulsky, G., Ecke, M., Maeda, M., Gaskins, C., Firtel, R.A.and Loomis, W.F.: "A MAP kinase necessary for receptor-mediated activation of adenylyl cyclase in Dictyostelium." J.Cell Biol.128. 405-413 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Oohata, A.: "Factors controlling prespore cell differentiation in Dictyostelium discoideum : Minute amounts of differentiation-inducing factor promote prespore cell differentiation." Differentiation. 59. 283-288 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Iwamoto, M., Yanagisawa, Y.and Tanaka, Y.: "Mitochondrial ribosomal protein L11 gene of Dictyostelium discoideum resides not in the nuclear genome but in the mitochondrial genome." DNA Res.2. 129-132 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fukuzawa, M.and Ochiai, H.: "Molecular cloning and characterization of the cDNA for Discoidin II of Dictyostelium discoideum." Plant Cell Physiol.37. 505-514 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ochiai, H., Hata, K., Saito, T., Funamoto, S.and Nakata, N.: "Dimer formation of a cell-cell adhesion protein, gp64 of the cellular slime mold, Polysphondylium pallidum." Plant Cell Physiol.37. 135-139 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nakata, N.and Ochiai, H.: "Inhibitory Effects of Tunicamycin on Cell Cell Adhesion and Cell Reaggregation of the Cellular Slime Mold, Polysphondylium pallidum." J.Plant Res.109. 193-199 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Amagai, A.and Maeda, Y.: "Dictyostelium mucoroides cells exhibit cell cycle-dependent sorting behavior as observed in D.discoideum development." Dev.Growth & Differ.38. 33-40 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Maeda, M., Aubry, L., Insall, R., Gaskins, C., Devreotes, P.N.and Firtel, R.A.: "Seven helix chemoattractant receptors transiently stimulate mitogen-activated protein kinase in Dictyostelium." J.Biol.Chem.271. 3351-3354 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yamaguchi, N., Higa, M., Aiba, K., Fang, H., Tanaka, Y.and Urushihara, H.: "Targeted disruption of genes for gp138, a cell-fusion-related protein in Dictyostelium discoideum, revealed the existence of a third gene." Dev.Growth & Differ.38. 271-279 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Pi, M., Angata, K., Ikemura, T., Yanagisawa, K.and Tanaka, Y.: "Analysis of a tRNA gene-like sequence (t-element) with TTA at the anticodon position in the mitochondrial DNA of Dictyostelium discoideum." J.Plant Res.109. 1-6 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Urushihara, H.and Aiba, K.: "Protease-sensitive component (s) on cell surface prevents self-fusion in a bisexual strain of Dictyostelium discoideum." Cell Struct.Funct.21. 41-46 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Urushihara, H.: "Choice of partners : Sexual cell interactions in Dictyostelium discoideum." Cell Struct.Funct.21. 231-236 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kuwayama, H., Viel, G.T., Ishida, S.and Van Haastert, J.T.M.: "Aberrant cGMP-binding activity in non-chemotactic Dictyostelium discoideum mutants." Biochim.Biphys.Acta. 1268. 214-217 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Oyama, M.: "cGMP accumulation induced by hypertonic stress in Dictyostelium discoideum." J.Biol.Chem.271. 5574-5579 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yumura, S.: "Rapid redistribution of myosin II in living Dictyostelium amoebae, as revealed by fluorescent probes introduced by electroporation." Protoplasma. 192. 217-227 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yumura, S.: "Spatial distribution of fluorescently labeled actin in living Dictyostelium amoebae." Cell Struct.Funct.21. 189-197 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Angata, K., Kuroe, K., Yanagisawa, K.and Tanaka, Y.: "Codon usage, genetic code and phylogeny of Dictyostelium discoideum mitochondrial DNA as deduced from a 7.3-kb region." Curr.Genet.27. 249-256 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Angata, K., Ogawa, S., Yanagisawa, K.and Tanaka, Y.: "A group-I intron in the mitochondrial large-subunit ribosomal RNA-encoding gene of Dictyostelium discoideim : same site localization in alga and in vitro self-splicing." Gene. 153. 49-55 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Morio, T., Adachi, H., Sutoh, K., Yanagisawa, K.and Tanaka, Y.: "Brs-REMI : An improved method for gene tagging using a new vector in Dictyostelium." J.Plant Res.108. 111-114 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Asahi, K., Sakurai, A., Takahashi, N., Kubohara, Y., Okamoto, K.and Tanaka, Y.: "DIF-1, morphogen of Dictyostelium discoideum, induces the erythroid differentiation in murine and human leukemia cells." Biochem.Biophys.Res.Comm.208. 1036-1039 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Higuchi, I., Kanemura, Y., Shimizu, H.and Urushihara, H.: "Self-and non-self-recognition in bisexual mating of Dictyostelium discoideum." Dev.Growth & Differ.37. 311-317 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kuwayama, H., Viel, G.T., Ishida, S.and Van Haastert, P.J.M.: "Aberrant cGMP-binding activity in non-chemotatic Dictyostelium discoideum." Biochim.Biophys.Acta.1268. 214-221 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Oyama, M.and Kubota, K.: "Activation of adenylate cyclase by divalent cations and polyamines in saponin-treated Dictyostelium cells." J.Biochem.118. 117-121 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Okazaki, K.and Yumura, S.: "Differential association of three actin-bundling proteins with microfilaments in Dictyostelium amoebae." Eur.J.Cell Biol.66. 75-81 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yumura, S., Matsuzaki, R.and Kitanishi-Yumura, T.: "Introduction of macromolecules into living Dictyostelium cells by electroporation." Cell Struct.Funct.20. 185-190 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yumura, S., Furuya, K., and Takeuchi, I.: "Intracellular free calcium responses during chemotaxis of Dictyostelium cells." J.Cell Sci.109. 2673-2678 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Saito, T.and Ochiai, H.: "Identification of a novel all-cis-5,9,12 heptadecatrienoic acid in the cellular slime mold Polysphondylium pallidum" Lipids. 31. 445-447 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Funamoto, S.and Ochiai, H.: "Antisence RNA inactivation of gene expression of a cell-cell adhesion protein (gp64) in the cellular slime mold Polysphondylium pallidum." J.Cell.Sci.109. 1009-1016 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fujita, H., Sugiura, S., Momoura, S., Omata, M., Sugi, H., and Sutoh, K.: "Characterization of mutant myosins equivalent to human familial hypertophic cardiomyopathy mutants." J.Clinc.Invest.(in press). (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Arakane, T.and Maeda, Y.: "Relevance of histone H1 kinase activity to the G2/M transition during the cell cycle of Dictyostelium discoideum." J.Plant Res.(in press). (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Okafuji, T., Abe, F.and Maeda, Y.: "Antisense-mediated regulation of Annexin Vll gene expression during the transition from growth to differentiation in Dictyostelium discoideum." Gene. (in press). (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Aubry, L., Maeda, M., Insall, R., Devreotes, P.N.and Firtel, R.A.: "The Dictyostelium MAP kinase ERK2 is regulated by Ras and cAMP-dependent protein kinase (PKA) and mediates PKA function." J.Biol.Chem.(in press). (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ogawa, S., Naito, K., Angata, K., Morio, T., Urushihara, H.and Tanaka, Y.A: "site-specific DNA endonuclease specified by one of two ORFs encoded by a group I intron in Dictyostelium discoideum mitochondrial DNA." Gene. (in press). (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Komori, K., Maruo, F., Morio, T., Urushihara, H.and Tanaka, Y.: "Localization of a DNA topoisomerase II to mitochondria in Dictyostelium discoideum : deletion mutant analysis and mitochondrial targeting signal presequence." J.Plant Res.(in press). (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Komori, K., Kuroe, K., Yanagisawa, K.and Tanaka.Y.: "Cloning and characterization of the gene encoding a mitochondrially localized DNA topoisomerase II in Dictyostelium discoideum : Western blot analysis." Biochim.Biophys.Acta. (in press). (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Aiba, K., Fang, H., Yamaguchi, N., Tanaka, Y.and Urushihara, H.: "Isoforms of gp138, a cell-fusion related protein in Dictyostelium discoideum." J.Biochem.(in press). (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ogawa, S., Mastuo, K., Angata, K., Yanagisawa, K.and Tanaka, Y.: "Group I introns in the cytochrome oxidase genes of Dictyostelium discoideum : two related ORFs in one loop of a group I intron, a cox1/2 hybrid gene and an unusually large cox3 gene. Curr." Genet.(in press). (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Shimizu, H., Morio, T., Shimizu, H.D.and Urushihara, H.: "A mutation in the cAMP signaling pathway affects sexual development of Dictyostelium discoideum." Dev.Growth & Differ.(in press). (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yumura, S.and Uyeda, T.P.Q.: "Myosin II can be localized to the cleavage furrow and to the posterior region of Dictyostelium amoebae without control by phosphorylation of myosin heavy and light chains." Cell Motil.Cytoskel.(in press). (1977)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-03-09  

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