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1997 Fiscal Year Final Research Report Summary

CROSS TALK BETWEEN BIOLOGICAL TRIPLET SYSTEMS (NEURO-ENDCRINE-IMMUNE) DURING LIVER REGENERATION

Research Project

Project/Area Number 07407030
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field General surgery
Research InstitutionASAHlKAWA MEDICAL COLLEGE

Principal Investigator

KASAI Shinichi  Asahikawa Medical College, Professor, 医学部, 教授 (40091566)

Co-Investigator(Kenkyū-buntansha) KINO Syuichi  Asahikawa Medical College, Associate, 医学部, 助手 (20234312)
KONO Toru  Asahikawa Medical College, Associate, 医学部, 助手 (60215192)
KATO Kazuya  Asahikawa Medicai College, Associate Professor, 医学部, 講師 (70175280)
Project Period (FY) 1995 – 1997
KeywordsThyrotropine-releasing hormone (TRH) / Neuropeptide Y (NPY) / central nervous systems (CNS) / liver regeneration / dorsal vagal complex (DVC) / bile secretion
Research Abstract

1) We suggest that the dual innervation of the liver and pancreas by single parasympathetic neurons in the vagal out put and input central nervous systems (CNS), might play a crucial role during liver regeneration. The spontaneous developed insulin-dependent diabetic rat is almost devoid of these dual innervation. After 70% hepatectomy in the diabetic rats, the liver regeneration was suppressed compared to the normal rats.
2) Central neuropeptides play a role as physiological regulators in the autonomic nervous system. One of these neuropeptides, Thyrotropine-releasing hormone (TRH), is distributed the central nervous system and acts as a neurotransmitter to regulate liver functions through the vagus nerve. However, the effect of TRH on the liver regeneration is unknown. Therfore, the CNS's effect of TRH on hepatic DNA synthesis was studied in rats. Our results indicate that TRH acts in the CNS to stimulate hepatic DNA synthesis through vagal and cholinergic mechanisms, and that TRH may be the chemical messenger involved in brain regulation of hepatic proliferation.
3) Central administration of neuropeptide Y (NPY) enbances bile secretion through vagal pathways in animal models. NPY nerve fibers and receptors are localized in the dorsal vagal complex (DVC), and retrograde tracing techniques have shown that hepatic vagal nerves are projected mainly from the left DVC.NPY acts in the left DVC to stimulate bile acid-independent and bicarbonate-dependent bile secretion through the left cervical and hepatic nerves ; these findings suggest that neuropeptides may act in the specific brain nuclei to regulate hepatic function.

  • Research Products

    (16 results)

All Other

All Publications (16 results)

  • [Publications] Kono T., et al: "Hepatic production of inducible nitricoxide synthase in patients with various liverdiseases." Liver. (in press). (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tamori K, et al: "Central administration of thyrotropin-releasing hormone analog increases hepatic blood flow in rats." American Journal of Physiology. (in press). (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yoneda M, et al: "Neuropeptide Y in the dorsal vagal complex stimulates bicarbonate dependent bile secretion in rats." Gastroenterology. 112. 1673-1680 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yoneda M, et al: "Central thyrotropin-releasing hormone stimulates hepatic DNA synthesis in rats." Hepatology. 26. 1203-1208 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kato K, et al: "Effect of hepatocyte growth factor(hHGF)on the proliferation of transplanted hepatocytes in the spleen." Transplantation Procedings. 29. 2029-2031 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 葛西 眞一、他: "肝臓および肝細胞移植と肝再生" 実験医学. 15. 2159-2164 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kato K, et al: "Effect of hepatocye growth factor on proliferation of intrasplenically transplanted hepatocytes in rats." Biochemical and Biophysical Research Communications. 222. 101-106 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 水戸 廸郎、他: "肝細胞再生機転研究のあゆみ" 肝胆膵. 30(1). 141-157 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kono T., S.Kino, J.Iwamoto, Yoneda M,S.Kasai: "Hepatic production of inducible nitric oxide synthase in patients with various liver diseases." Liver. (in press). (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tamori K,Yoneda M,Makino I: "Central administration of thyrotropin-releasing hormone analog increases hepatic blood flow in rats." American Journal of Physiology. (in press). (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yoneda M,Yokohama S,et al.: "Neuropeptide Y in the dorsal vagal complex stimulates bicarbonate dependent bile secretion in rats." Gastroenterology. 112. 1673-1680 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yoneda M., Kono T., et al.: "Central thyrotropin-releasing hormone stimulates hepatic DNA synthesis in rats." Hepatology. 26. 1203-1208 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kato K., Kasai S., Onodera K., Sawa M., Imai M., Kawahara T., Mito M.: "Effect of hepatocyte growth factor (hHGF) on the proliferation of transplanted hepatocytes in the spleen." Transplantation Procedings. 29. 2029-2031 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kasai S., Kato K., Mito M.: "Transplantation and regeneration of liver and hepatocyte." Experimental Medicine. 15. 2159-2164 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kato K., K.Onodera, M.Sawa, M.Imai, T.Kawahara, S.Kasai, M.Mito: "Effect of hepatocye growth factor on proliferation of intrasplenically transplanted hepatocytes in rats." Biochemical and Biophysical Research Communications. 222. 101-106 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Mito M., Kono T.: "Study oh liver cell regeneration-review." Kan・Tan・Sui. 30 (1). 141-157 (1995)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-03-16  

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