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1998 Fiscal Year Final Research Report Summary

STUDIES ON INTRACTABLE ORAL MUCOSAL LESIONS

Research Project

Project/Area Number 07407057
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionDOKKYO UNIVERSITY SCHOOL OF MEDICINE

Principal Investigator

FUJIBAYASHI Takashi  Dokkyo University School of Medicine, Professor, 医学部, 教授 (80013978)

Co-Investigator(Kenkyū-buntansha) AZUMA Miyuki  Juntendo University, School of Medicine, Instructor, 医学部, 助手 (90255654)
ASAKURA Setsuko  Dokkyo University School of Medicine, Instructor, 医学部, 助手 (60296134)
SHIODA Yoshimi  Dokkyo University School of Medicine, Instructor, 医学部, 助手 (40285862)
SHINOHARA Makoto  Dokkyo University School of Medicine, Instructor, 医学部, 助手 (10245102)
SASAKI Tadaaki  Dokkyo University School of Medicine, Lecturer, 医学部, 講師 (40225876)
Project Period (FY) 1995 – 1998
KeywordsOral Mucosal Lesions / Intractable Disease / Immunological Study / Costimulatory Molecules / Prognostic Determinant Factor / Oral Precancerous Lesion / Sjogren's Syndrome / Diagnostic Criteria
Research Abstract

1. Immunological investigation on intractable oral mucosal lesions with special focus on oral mucosal cancers The cytotoxic activities of anti-CD3 induced LAX ceUs were sbicied with oral scwmous cell carcinoma derived target cells after preincubation with chemotherapeutic reagents such as CDDP, 5FU, PEP, BLM.The cytotoxic activity varied with reagent applied, HLA class I, II expression also showed some variations.
2. lrrvestigation on immunological response through coslimulatory molecules in intractable oral , mjcosal lesions Mouse model of hapten induced contact dermatitis were studied. Strong increase of CD86 expression on Langerharis cells and some increase of CD8O, CD86 both positive cells were observed after skin sensitization. The skin reaction was depressed by ackninistration of anti-CTLA-4 antibody.
3. Investigation on prognosis of intractalAe oral mucosal lesions Multivariate evaluation of prognostic determinant factors for oral squamous cell carcinomas using Cox'proportional ha … More zards model revealed that pattern of invasion in histopathology, T classification, treatment modality were most significant prognostic factors. Other oral mucosal lesions such as oral precancerous lesions like oral letkoplakia, oral precancerous condition related lesions like oral lichen planus were also studied.
4. Investigation on clinical features of intractable oral mucosal lesions Clinical featres of Siogrerfssynch-ome and xerostomia were mostly investigated. Diagnostic criteria for Siogren's syndrome play key role for differential diagnosis of the both diseases. Head investigator attended working cornmrttee for revision of Jaanese diagnosbc cnteria in Japanese Association for Sjogren's Synckome. Total number of 823 cases of Siogren's synciome inducing normal control was assayed for sensitivity and specificity in diagnosis using various revised criteria. Final revised diagnostic criterion for Siogreri's syndome has completed through discussion in Japanese Association for Sjogren's syndrome. Less

  • Research Products

    (22 results)

All Other

All Publications (22 results)

  • [Publications] Takashi Fujibayashi: "Comparative study on sensitivity and Specificity of various diagnostic criteria of Sjogren's syndrome." Clinical Rheumatology. 14. suppl 1. 21-22 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Azuma, M., Lanier, L. L.: "The role of CD28 Costimulation in the generation of cyfatoxic T lymphocytes" Curr. Topics Microbiol. Immunol.198. 59-74 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nuriya, S.Azuma, M.et al.: "The differential role of CD86 and CD80 Costimulatory mdeules in the indcution and effector phase of contact hypersensitivity" Int, Immunol.8. 917-926 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Takashi Fujibayashi, et al: "Preliminary revision of the Japanese criteria for Sjogren's syndrome" J, Rheumatol.24. 38-38 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tadaaki Sasaki: "Multivariate evaluation of prognostic determinant factors for oral squanous cell carcinomas" Dokkyo J.Med.Sci.24・2. 109-115 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 藤林孝司: "シェーグレン症候群に関する最近の研究展望" 日本口腔粘膜学会雑誌. 4・2. 75-90 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 藤林孝司: "総合口腔診断学" 砂書房, 1-645 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 藤林孝司: "リウマチ'97" メディカルレビュー社, 1-239 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Takashi Fujibayashi: "Comparative study on senssitivity and specificity of various diagnostic criteria for Sjogren's syndrome." Clinical Rheumatology. 14-suppl.1. 21-22 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Miyuki Azuma: "The role of CD28 costimulation in the generation of cytotoxic T lymphocytes." Current Topics in Microbiology and Immunology. 198. 59-74 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takashi Fujibayashi: "Oral cavity and immune responses." Journal of Otolaryngology, Head and Neck Surgery. 12-1. 63-69 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nuriya, S.: "The differential role of CD86 and CD80 costimulatory molecules in the induction and effector phase of contact hypersensitivity." International Immunology. 8. 917-926 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takashi Fujibayashi: "Comparative study on various classification criteria of Sjogren's syndrome." Journal of Japanese Society for Oral Mucous Membrane. 2-1. 60-68 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takashi Fujibayashi: "Immunotherapy of cancer." Dental Outlook. 88-6. 1363-1372 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nobuyuki Miyasaka: "Ishiyaku Publisshers, Inc." Intractable conditions in connective tissue disease. 1-114 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takashi Fujibayashi: "Proposal of revised diagnostic criteria for Sjogren's syndrome." Report of Research Committee on Autoimmune Diseases in the Ministry of Health and Welfare. 58-60 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takashi Fujibayashi: "Diagnostic criteria for xerostomia especially for Sjogren's syndrome." the Quintessence. 16-5. 1063-1072 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takashi Fujibayashi: "Drug therapy of oral lichen planus." The Journal of Practical Pharmacy. 48-6. 891-897 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takashi Fujibayashi: "Preliminary revision of the Japanese criteria for Sjogren's syndrome." Journal of Rheumatology. 24. 38-38 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tadaaki Sasaki: "A study on prognostic factors for survival in patients with head and neck squamous cell carcinomas by multivariate analysis." Oral Oncology. 5. 120-123 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tadaaki Sasaki: "Mutivariate evaluation of prognostic deter-minant factors for oral squamous cell carcinomas." Dokkyo Journal of Medical Science. 24-2. 109-115 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takashi Fujibayashi: "A review of recent studies on Sjogren's syndrome." Journal of Japanese Society for Oral Mucous Membrane. 4-2. 75-90 (1998)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-12-08  

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