1997 Fiscal Year Final Research Report Summary
The Characteristics of Y Chromosome in Japanese
| Project/Area Number |
07407064
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human genetics
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| Research Institution | The University of Tokyshima (1997)
The University of Tokyo (1995-1996) |
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Principal Investigator |
NAKAHORI Yutaka The University of Tokushima, School of Medicine Department of Public Health, Professor, 医学部, 教授 (10172389)
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| Co-Investigator(Kenkyū-buntansha) |
TODA Tatsushi The Institute of Medical Science, The University of Tokyo, Department of Genome, 医科学研究所, 助教授 (30262025)
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| Project Period (FY) |
1995 – 1997
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| Keywords | Y-chromosome / Japanese / DNA polymorphism |
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| Research Abstract |
The Y chromosome is a single haploid entity passed only from father to son, and thus it represents the paternal lineage in human males. DNA markers located in non-recombining part of the Y chromosome are especially useful for tracing the paternal lineage in evolutionary studies. However, progress in this field has been slow because it has been difficult to find suitable markers. We have been studying the Y chromosome structure and reported some polymorphisms found in Japanese. Here, we report the PCR-based techniques for 3 DNA polymorphisms in SRY,DXYS5Y and DXYS241 loci on the Y chromosome. Using these techniques as well as YAP polymorphism, we have analyzed the Y chromosome of Japanese males and constructed a genealogical tree of the Y chromosome. The Japanese Y chromosomes were classified into 4 groups (i.c., haplotypes) based on the allele combintion in the 4 loci. Population study of these hapotypes in the Korean, Caucasian, Negroid and Okinawan samples illustrated the characteristics of the Y chromosome in Japanese and indicated the origin of the Japanese males.
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[Publications] Ito, T., Kaino, Y., Hirai, H., Kida, K., Nakahori, Y., Nakagome, Y.: "ex reversal in a child with duplication of sex reversing locus on the short arm of the x chromosome (Xp)" J.of Pediatric Endocrinology Metabolism (JPEM). 9. 429-433 (1996)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Miyake, M., Nakahori, Y., Matsushita, I., Kobayashi, K,Mizuno, K., Hirai, M., Kanazawa, I., Nakagome, Y., Tokunaga, Toda, T.: "YAC and cosmid contigs emcompassing the Fukuyama-type congenital muscular dystrophy (FCMD) candidate region on 9q31" Genomics. 40. 284-293 (1997)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Kotliarova, E.S., Toda, T., Takenaka, O., Matsushita, I., Hida, A., Shinka, T., Goto, J., Tokunaga, K., Nakagome, Y., Nakahori, Y.: "Novel Marker DXYS241 on the human Y chromosome shows four evolutionary event after divergence of human and chimpanzee" Hum.Biol.(in press).
Description
「研究成果報告書概要(欧文)」より
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[Publications] Yoshida, A., Nakahori, Y., Kuroki, Y., Motoyama, M., Araki, Y., Miura, K., Shirai, M.: "Dicentric Y Chromosome in an Azoospermic Male." Mol.Hum.Reproduction. 3. 709-712 (1997)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Toda, T., Miyake, M., Nakahori, Y., Segawa, M., Nomura, Y., Nonaka, I., Ikegawa, S., Kondo, E., Saito, K., Fukuyama, Y., Yoshioka, M., Shimizu, T., Kanazawa, I., Nakamura, Y., Nakagome, Y.: Toward the identification of the Fukuyama type congenital muscular dystrophy (FCMD) gene. in Fukuyama, Y., Osawa, M., Saito, Keds : Congenital Muscular Dystrophies.Elsevier, Tokyo, 301-308 (1997)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Kotliarova, E.S., Matsusshita, I., Shinka, T., Hida, A., Toda, T., Tokunaga, K., Nakagome, Y., Nakahori, Y.: Novel polymorphic CA repeat on the Yp11 with non-random allele distribution on sex chromosomes is a useful marker for forensic analysis. ISFH Hakone symposium on DNA polymorphisms. TOYOSHOTEN, 108-112 (1997)
Description
「研究成果報告書概要(欧文)」より
