1996 Fiscal Year Final Research Report Summary
Population genetics analysis of blood group-related genes
| Project/Area Number |
07454206
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
遺伝
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| Research Institution | National Institute of Genetics |
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Principal Investigator |
SAITOU Naruya National Institute of Genetics, Laboratory of Evolution of Genetics, Associate Professor, 集団遺伝研究系, 助教授 (30192587)
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| Co-Investigator(Kenkyū-buntansha) |
UEDA Shintaroh University of Tokyo, Granduate School of Science, Associate Professor, 大学院・理学系, 助教授 (20143357)
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| Project Period (FY) |
1995 – 1996
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| Keywords | molecular evolution / ABO blood group / chimpanzee / Network method / molecular phylogenetic analysis / sugar transferase |
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| Research Abstract |
There are three common alleles (A,B,and O) at the human ABO blood group locus. We compared nucleotide sequences of these alleles, and relatively large numbers of nucleotide differences were found among them. These differences correspond to the divergence time of at least a few million years, which is unusually large for a human allelic divergence under neutral evolution. We constructed phylogenetic networks of human and non-human primate ABO alleles, and at least three independent appearances of B alleles from the ancestral A form were observed. These results suggest that some kind of balancing selection may have been operating at the ABO locus. We also constructed phylogenetic trees of ABO and their evolutionarily related alpha-1,3-galactosyltransferase genes, and the divergence time between these two gene families was estimated to be roughly 400 million years ago.
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[Publications] Ogasawara, K., Bannai M., Saitou N., Yabe R., Nakata K., Takenaka M., Fujisawa K., Uchikawa M., Ishikawa Y., Juji T., and Tokunaga K.: "Extensive polymorphism of ABO blood group gene : 1. Three major lineages of the alleles for the common ABO phenotypes." Human Genetics. Vol.97. 777-783 (1996)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Ogasawara K., Yabe R., Uchikawa M., Saitou N., Bannai M., Nakata K., Takenaka M., Fujisawa K., Juji T., and Tokunaga K.: "Molecular genetic analysis of the variant phenotypes of ABO blood group system." Blood. Vol.88, No.7. 2732-2737 (1996)
Description
「研究成果報告書概要(欧文)」より
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