1996 Fiscal Year Final Research Report Summary
Chiral Recognition of Host Molecules Determined by Mass Spectrometry
| Project/Area Number |
07454250
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Organic chemistry
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| Research Institution | Osaka University |
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Principal Investigator |
SAWADA Masami Osaka University, ISIR,Associate Professor, 産業科学研究所, 助教授 (70029883)
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| Co-Investigator(Kenkyū-buntansha) |
TAKAI Yoshio Osaka University, ISIR,Research Associate, 産業科学研究所, 助手 (20127244)
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| Project Period (FY) |
1995 – 1996
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| Keywords | Chiral Recognition / Host-Guest Complex / Enantiomer / FAB Mass Spectrometry / ESI Mass Spectrometry / Deuterium Label / Amino Acid / Chiral Crown Ether |
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| Research Abstract |
In the last year, we coult successfully develop a new methodology for chiral recognition in the highly structured host-guest complexation systems, which we called as "FABMS/EL (Enantiomer-Labeled) guest method", and clarify the fundamental aspects of this newly developed method. Chiral recognition ability was evaluated by the IRIS values : I [(H+G_R) ^+] /I [(H+G_<S-dn>) ^+].
In this year, (i) we applied this method to various host molecules, and (ii) we extended this method to ESI (Electrospray Ionization) mass spectrometry, that is, "ESIMS/EL guest method".
(1) As the results of "FABMS/EL guest method", it was concluded that various chiral crown ethers, carbohydrates, and antibiotics exhibit various degree of chiral recognition toward various amino acids their esters within the range of IRIS=5.0-0.2.
(2) As the results of "ESIMS/EL guest method", it was conculuded that ESIMS provides certain depressed IRIS values compared with FABMS so that cautions are required for evaluating chiral recognition ability in a quantitative fashion.
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