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1997 Fiscal Year Final Research Report Summary

Physiological Roles of a Novel Calcium Phospholipid Binding Protein, Annexin V,in the Function of the Anterior Pituitary Gland and the Ovary ; A Molecular-Cellular Biological Approach

Research Project

Project/Area Number 07456136
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Basic veterinary science/Basic zootechnical science
Research InstitutionKitasato University

Principal Investigator

KAWAMINAMI Mitsumori  Kitasato University.Associate Professor, 獣医畜産学部, 助教授 (00153007)

Co-Investigator(Kenkyū-buntansha) NISHIHARA Masugi  University of Tokyo Associate Professor, 農学部, 助教授 (90145673)
HASEGAWA Yoshihisa  Kitasato University Professor, 獣医畜産学部, 教授 (40092001)
KURUSU Shiro  Kitasato University Research Associate, 獣医畜産学部, 助手 (50215076)
Project Period (FY) 1995 – 1997
Keywordsannexin V / prolactin / luteinizing hormone / mRNA / pituitary / ovary / hypothalamus / LHbeta subunit
Research Abstract

Physiological importance of a novel calcium-phospholipid binding protein, annexin V,in functions of the anterior pituitary gland and the ovary was investigated. By immunocytochemical approach, the specific distribution of annexin V on gonadotrophs at the anterior pituitary gland was demonstrated. The amount of this protein in the anterior pituitary gland was revealed to increase after ovariectomy. It was shown that ovariectomy enhances annexin V synthesis also by Northern blot analysis. These results led us to examine the effect of GnRH on annexin V synthesis and we found a stimulating effect of GnRH on annexin V mRNA accumulation. In turn, annexin V increased LH beta mRNA.Getting together, annexin V is thought to be a novel signal transducer of GnRH at pituitary gonadotrophs. Annexin V is hypothesized to be a physiological modulator also at the ovary. The distribution of annexin V was shown to restricted to luteal cells. Granulosa cells showed neither annexin V nor its mRNA.Furthermore, luteal annexin V varies its concentration along with pseudopregnancy. These results suggest annexin V would play a role in luteal progestational function. We also examined the effect of annexin V in neural system by observing single unit activity (SUA) recorded with a section of hypothalamus in vitro. Even though we have only preliminary data, annexin V was shown to inhibit or stimulate significantly the neural firing activity. The present project on the physiological role of annexin V raises a possibility that annexin V exerts specific activity locally in various tissues. Among these, its signal transducing action at gonadotrophs is the first observation on its activity of physiological modulator.

  • Research Products

    (85 results)

All Other

All Publications (85 results)

  • [Publications] Kurusu S: "Detection of cytosolic phospholipase A2(cPLA2)in rat corpola lutea:relationship to functional luteolysis." J.Reprod.Dev.41. 141-147 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Madarame H: "Spontaneousrhabdomyosarcomas in aged mastomys (Praomys coucha)." Lab.Anim.29. 464-469 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Takai S: "Pathogenesis of Rhodococcus equi infection in mice:Roles of vilurence plasmids andgranulomagenic activity of bacteria." FEMS Immunol Med Microbiol.11. 181-190 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kawada T: "Decreased immunoreactive inhibin and increasedFSH levels in cryp-torchism after orchdopexy." Endocrine J.42. 577-580 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kaneko H: "Changes inplasma concentrations of immunoreactive inhibin,estradiol and ESH associated with follicularwaves during the estrous cycle of the cow" J.Reprod.Develop.41(4). 311-320 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kaneko H: "Immunoneutralization of inhibin and estradiol during the follicular phase of theestrous cycle in the cows." Biol.Reprod.53. 931-939 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Mine T: "Effects of inhibin on activin A-induced gulucose metabolism in rat hepatocytes." Endocrine. 5. 41-46 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Madarame H: "Immunohistochemical detection of virulence-associated antigens of Rhodococcus equi inpulmonary lesions of foals." Vet.Pathol.33. 341-343 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 水沼 英樹: "IR-インヒビン測定キットの有用性に関する検討" ホルモンと臨床. 44. 537-545 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 長谷川 喜久: "インヒビンとアクチビンの発見とその後の展開" 獣医畜産新報. 49(2). 129-133 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ikeda A: "hGH transgenic rats expressing severe obesity and effect of treatment with hGH in a pulsatile manner." Endocrine J.43(Suppl). S99-S101 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Onami S: "Splenic macrophages alter the steroidgenesis of Leydig cells in vitro." EndocrineJ.43. 477-485 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nishimura F: "Excitability of neurons in the ventromedial nucleus in rat hypothalamic slices:Modulation by amino acids at cerebrospinal fluid levels." Brain.Res.691. 217-222 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Suzuki M: "Hypothalamic gonadotropin-releasing hormone gene expression during rat estrous cycle." Endocrine J.42. 789-796 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yamanouchi K: "Molecular cloning of cDNA for inhibin α-subunit from equine ovary." J.Vet.Med.Sci.57. 905-909 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yoshida S: "Molecular cloning of cDNA for equine ovarian inhibin/activin β-subunit." J.Vet.Med.Sci.57. 469-473 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 松山 茂実: "ラット黄体退行をモデルとしたcDNAサブトラクション法によるプログラム細胞死最初期遺伝子の探索" 獣医畜産新報. 48. 117-118 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kawaminami M: "Intrapituitary distribution and effects of annexin 5 on prolactin release" Endocrine. 5. 9-14 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Madarame H: "Virulent and avirulent Rhodococcus equi infection in T-cell deficient athymic unde mice:pathologic,bacteriologic and immunologic responces." FEMS Immunology and Medical Microbiology. 17. 251-262 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hasegawa Y: "Isolation and characterization of inhibin andinhibin-related proteins." J.Reprod.Develop.42(Suppl.). 23-25 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kaneko H: "Follicular growth and FSH secretion incattle." J.Reprod.Develop.42(Suppl.). 37-40 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yoshida S: "A novel steroid inhibitor for a rat 20α-hydroxysteroid dehydrogenase isozyme(HSD1)." Biol.Reprod.57. 1433-1437 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yamanouchi K: "Inhibin α-subunit mRNA is expressed in the corpus luteum of the pregnant mare." J.Reprod.Develop.43. 267-270 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ikeda A: "Different female reproductive phenotypes determined by human growth hormone(hGH)levels in hGH-transgenic rats." Biol.Reprod.56. 847-851 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hirasawa M: "The rostral ventrolateral medulla mediates suppression of the circulatory system by the ventromedial nucleus of the hypothalamus." Brain.Res.724. 186-190 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nishimura F: "Changes in chemical sensitivity of rat ventromedial hypothalamic neurons by food deprivation." Physiol.Behav.60. 7-12 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hirasawa M: "Neural activity in the VMH associated with suppression of the circulatory system in rats." Physiol.Behav.59. 1017-1023 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Matsuyama S: "Occurrence of deoxyribonucleic acid fragmentation during prolactin induced-structural luteolysis in cycling rats." Biol.Reprod.54. 1245-1251 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Noguchi J: "Ontogeny of inhibin secretion in the testis:secretion of inhibin-related pro-teins from fetal Leydig cells and of bioactive inhibin from Sertoli cells." J.Endocrinology. 155. 27-34 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kaneko H: "Inhibin is involved in the suppression of FSH secretion in the growth phase of the dominantfollicle during the early luteal phase in cows." Domestic Animal Endocrinology. 14(4). 263-271 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kurusu S: "Role of cytosolic phospholipase A2 in eicosanoid generation by corpora lutea of pseudopregnant rat:effects of its specific inhibitor" Prostaglandins,Leukotrienes and Essential Fatty A cids. 57(2). 119-124 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kawaminami M: "Immunocytochemical localization of annexin 5,a calcium dependent phospholipid binding protein,in rat endocrine organs" Cell and Tissue Research. (in press.). (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Suzuki M: "Identification of sex steroid-inducible genes in the hypothalamus of neonatal rats by cDNA subtraction." Neurosci.Lett.(in press.). (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Bannai M: "Effect of injection of antisense oligonucleotides of GAD isozymes into rat VMH on food intake and locomotor activity." Brain.Res.(in press.). (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kawaminami M: "Ovariectomy enhances the expression of annexin 5 in the anterior pituitary gland and induces nuclear translocation in rat gonadotrophs" Moll.Cell.Endoc.(in press.). (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yamanouchi K: "Equine inhibin/activin βA-subunit mRNA is expressed in the endometrial gland,but not in the trophoblast,during pregnancy." Mol.Repod.Develop.47. 1-7 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ordog T: "On the role of gonadotropin-releasing hormone(GnRH)in the operation of the GnRH pulse generator in the rhesus monkey." Neuroendocrinology. 65. 307-313 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 高橋 迪雄: "生殖機能と下垂体前葉機能調節系" ヒューマン・サイエンス. 9. 77-85 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yoo MJ: "Involvement of prostaglandins in suppression of gonadotropin-releasing hormone pulse generator activity by tumor necrosis factor-a." J.Reprod.Develop.43. 181-187 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yoo MJ: "Tumor necrosisfactor-a mediates endotoxin induced suppression of gona-dotropin-releasing hormone pulse generator activvity in the rat." Endocrine J.44. 141-148 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kanuka H: "Prolactin expresses differential effect on apoptotic cell death of luteal cells in vivo and in vitro." Endocrine J.44. 11-22 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hasegawa Y: "Role of Inhibin and Activin in the Gonadal Development and Functions." Sugawara S,Umezu M and Tsijii H eds.,in"Embryo Transferand Genetic Micromanipulation",Sendai, 151-160 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nishihara M: "Hypothalamic control of gonadotropin secretion in the rat:Electro-physiological study." Proceedings of Sixth Lake Shirakaba Conference 1994,Biology of Pregnancy,Nakayama T&Makino T(eds.),Keiseisha,Tokyo,11-20 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Mizunuma H: "Evaluation of maternal serum inhibin as a marker for complicated pregnancy.in"Inhibin,Activin and Follistatin."" Eds.Aono T,Sugino H and Walw W,Springer-Verlag,New York,151-161 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nishihara M: "Controlling mechanism of GnRH pulse generator activity in the rat.In:Neural Control of the Reproduction:Physiology and Behavior." Maeda K,Tsukamura H,Yokoyama A(eds)Japan Scientitic Societies Press,Tokyo/Karger,Basel,31-55 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hasegawa Y: "Inhibin and Activin:Novel Regulators for Gonadal Function and Sexual Maturation." in"SEXUAL DIFFERENTIATION AND MATURATION"Ares-Serono Symposia Publications,139-154 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hasegawa Y: "Two-site immunoassay for native inhibin A.in"Inhibin,Activin and Follistatin."" Eds.Aono T,Sugino H and Walw W,Springer-Verlag,New York,104-117 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Suzuki M: "Regulation of the expression of gonadotropin-releasing hormone gene in the hypothalamus.In:Reproductive Biology Update:Novel Tools for Assesment of Enviromental Toxicity." Miyamoto H,Manabe N(eds),Nakanishi Printing Co.,Kyoto,261-269 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 西原 真杉: "脳と生殖-GnRH神経系の進化と適応-生殖の神経内分泌調節" 学会出版センター(印刷中), (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kurusu S,Shingaki, S,Munekata Y,Kawaminami M,Hashimoto I: "Detection of cytosolic phospholipase A2 (cPLA2) in rat corpola lutea : relationship to functional luteolysis" J.Reprod.Dev.41. 141-147 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Madarame H,KashimotoY,KawamotoT,Toyonaga S and Hasegawa Y: "Spontaneousrhabdomyosarcomas in aged mastomys (Praomys coucha)." Lab.Anim.29. 464-469 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takai S, Madarame H,Matsmoto C,Inoue M,Sasaki Y,Hasegawa Y,Tsubaki S and Nakane A: "Pathogenesis of Rhodococcus equi infection in mice : Roles of vilurence plasmids andgranulomagenic activity of bacteria." FEMS Immunol Med Microbiol.11. 181-190 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kawada T,Yamanaka H and Hasegawa Y: "Decreased immunoreactive ingibin and increased FSH levels in crypotorchism after orchdopexy." Endocrine J.42. 577-580 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kaneko H,Kishi H,Watanabe G,Taya K,Sasamoto S and Hasegawa Y: "Changes inplasma concentrations of immunoreactive inhibin, estradiol and ESH associated with follicularwaves during the estrous cycle of the cow." L.Reprod.Develop.41(4). 311-320 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kaneko H,Nakanishi Y,Akagi S,Arai K,Taya K,Watanabe G,Sasamoto S and Hasegawa Y: "Immunoneutralization of inhibin and estradiol buring the follicular phase of theestrous cycle in the cows." Biol.Reprod.53. 931-939 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nishimura F,Nishihara M,Mori M,Torii K,Takahashi M: "Excitability of neurons in the ventromedial nucleus in rat hypothalamic slices : Modulation by amino acids at cerebrospinal fluid levels." Brain.Res.691. 217-222 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Suzuki M,Nishihara M,Takahashi M: "Hypothalamic gonadotropin-releasing hormone gene expression during rat estrous cycle." Endocrine.J. 42. 789-796 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yamanouchi K,Yoshida S,Hasegawa T,Ikeda A,Chan KT,Matsuyama S,Nishihara M,Miyazawa K,Takahashi M: "Molecular cloning of cDNA for inhibin s-subunit from equine ovary." J.Vet.Med.Sci.57. 905-909 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yoshida S,Yamanouchi K,Hasegawa T,Ikeda A,Suzuki M,Chan KT,Matsuyama S,Nishihara M,Takahashi M: "Molecular cloning of cDNA for equine ovarian inhibin/activin bA-subunit." J.Vet.Med.Sci.57. 469-473 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kawaminami M,Okazaki K,Uchida S,Marumoto N,Takehara K,Kurusu S,Hashimoto I,Walker AM: "Intrapituitary distribution and effects of annexin 5 on prolactin release." Endocrine. 5. 9-14 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Mine T,Yasuda H,Fujita T and Hasegawa Y: "Effects of inhibin on activin A-induced gulucose metabolism in rat hepatocytes" Endocrine. 5. 41-46 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] MadarameH,Takai S,Morisawa N,Fujii M,Hidaka D,Tsubaki S and Hasegawa Y: "Immunohistochemical detection of virulence-associated antigens of Rhodococcus equi inpulmonary lesions of foals." Vet.Pathol.33. 341-343 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Onami S,Matsuyama S,Nishihara M,Takahashi M: "Splenic macrophages alter the steroidgenesis of Leydig cells in vitro." Endocrine J.43. 477-785 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hirasawa M,Nishihara M,Takahashi M: "The rostral ventrolateral medulla mediates suppression of the circulatory system by the ventromedial nucleus of the hypothalamus." Brain.Res.724. 186-190 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nishimura F,Nishihara M,Torii K,Takahashi M: "Changes in chemical sensitivity of rat ventromedial hypothalamic neurons by food deprivation." Physiol.Behav.60. 7-12 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hirasawa M,Noshihara M,Takahashi M: "Neural activity in the VMH associated with suppression of the circulatory system in rats." Physiol.Behav.59. 1017-1023 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Matsuyama S,Chang KT,Kanuka H,Ohnishi M,Ikeda A,Nishihara M,Takahashi M: "Occurrence of deoxyribonucleic acid fragmentation during prolactin induced-structural luteolysis in cycling rats." Biol.Reprod.54. 1245-1251 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kurusu S,Noguchi T,Kawaminami M,Hashimoto I: "Role of cytosolic phospholipase A2 in eicosanoid generation by corpora lutea of pseudopregnant rats : effects of its specific inhibitor" Prostaglandins, Leukotrienes and Essential Fatty Acids. 57(2). 119-124 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Noguchi J,Hikono H,Sato S,Watanbe G,Taya K,Sasamoto S and Hasegawa Y: "Ontogeny of inhibin secretion in the testis : secretion of inhibin-related proteins from fetal Leydig cells and of bioactive inhibin from Sertoli cells." J.Endocrinology. 155. 27-34 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kaneko H,Taya K,Watanabe G,Noguchi J,Kikuchi K,Shimada A,and Hasegawa Y: "Inhibin is involved in the suppression of FSH secretion in the growth phase of the dominantfollicle during the early luteal phase in cows." Domestic Animal Endocrinology. 14(4). 263-271 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Madarame H,Takai S,Matsumoto C,Minamiyama K,Sasaki Y,Tsubaki S and Hasegawa Y: "Virulent and avirulent Rhodococcus equi infection in T-cell deficient athymic nude mice : pathologic, bacteriologic and immunologic responces." FEMS Immunology and Medical Microbiology. 17. 251-262 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hasegawa Y,Madarame H and Ibuki Y: "Isolation and characterization of inhibin andinhibinrelated proteins." J.Reprod.Develop. 42 (Suppl.). 23-25 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kaneko H,Watanabe G,Taya K and Hasegawa Y: "Follicular growth and FSH secretion incattle." J.Reprod.Develop. 42 (Suppl.). 37-40 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yoshida S,Shiota K,Nishihara M,Takahashi M: "A novel steroid inhibitor for a rat 20a-hydroxysteroid dehydrogenase isozyme (HSD1)." Biol.Reprod.57. 1433-1437 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yamanouchi K,Ikeda A,Matsuyama S,Hasegawa T,Sugawara Y,Nishihara M,Tojo H,Sawasaki T,Miyazawa K,Tachi C,Takahashi M: "Inhibin a-subunit mRNA is expressed in the corpus luteum of the pregnant mare." J.Reprod.Develop. 43. 267-270 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] KedaA,Matsumoto Y,Chang KT,Nakano T,Matsuyama S,Yamanouchi K,Nishihara M,Tojo H,Sasaki F,Takahashi M: "Different female reproductive phenotypes determined by human growth hormone (hGH) levels in hGH-transgenic rats." Biol.Reprod.56. 847-851 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yamanouchi K,Hirasawa K,Hsegawa T,Ikeda A,Chang KT,Matsuyama S,Nishihara M,Miyazawa K,Sawasaki T,Tojo H,Tachi C,Takagashi M: "Equine inhibin/activin bA-subunit mRNA is expressed in the endometrial gland, but not in the trophoblast, during pregnancy." Mol.Repod.Develop.47. 1-7 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ordog T,Chen MD,Nishihara M,Connaughton MA,Goldsmith JR,Knobil E: "On the role of gonadotropin-releasing hormone (GnRH) in the operation of the GnRH pulse generator in the rhesus monkey." Neuroendocronology. 65. 307-313 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yoo MJ,Nishihara M,Takahashi M: "Involvement of prostaglandins in suppression of gonadotropin-releasing hormone pulse generator activity by tumor necrosis factor-a." J.Reprod.Develop. 43. 181-187 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yoo MJ,Nishihara M,Takahashi M: "Tumor necrosis factor-a mediates endotoxin induced suppression of gonadotropin-releasing hprmone pulse generator activity in the rat." Endocrine J.44. 141-148 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kanuka H,Matsuyama s, Ohnishi M,Matsumoto Y,Nishihara M,Takahashi M: "Prolactin expresses differential effect on apoptotic cell death of luteal cells in vivo and in vitro." Endocrine J.44. 11-22 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kawaminami M,Kawamoto T,Tanabe T,Yamaguchi K,Mutoh K-I,Kurusu S,Hashimoto I: "Immunocytochemical localization of annexin 5, a calcium dependent phospholipid binding protein, in rat endocrine organs" Cell and Tissue Research. (in press). (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Suzuki M,Yoshida S,Nishihara M,TakahashiM: "Identification of sex steroid-inducible genes in the hypothalamus of neonatal rats by cDNA subtraction." Neurosci.Lett.(in press). (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Bannai M,Ichikawa M,Nishihara M,Takahashi M: "Effect of injection of antisense oligonucleotides of GAD isozymes into rat VMH on food intake and locomoto activity." Brain.Res.(in press). (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kawaminami M,Yamaguchi K-I,Miyagawa S,Numazawa S,Ioka H,Kurusu S and Hashimoto I: "Ovariectomy enhances the expression of annexin 5 in the anterior pituitary gland andpinduces nuclear translocation in rat gonadotrophs" Moll Cell Endoc.(in press). (1998)

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Published: 1999-03-16  

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