| Research Abstract |
This research project developed smoothly and following four points have been achieved.
1) We found that transcriptional control of GATA-1 is in definitive hematopoiesis distinct from that in primitive hematopoietic cells.
2) A new method of mouse gene disruption, knock-down, has been established in this study and, by using that approach, we proved that GATA-1 is essential for both primitive and definitive hematopoiesis.
3) We found that MafK,a small subunit of NF-E2, is expressed from two alternative tissue specific promoters, IM and IN.
4) We found a novel CNC factor regulator Keap1 which is important for phase II detoxifying enzyme gene expression.
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