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1997 Fiscal Year Final Research Report Summary

Closs talk between neuroendocrine and mucosal immune systems in the gastrointestinal mucosa and its disorder

Research Project

Project/Area Number 07457045
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Human pathology
Research InstitutionTohoku University

Principal Investigator

NAGURA Hiroshi  Tohoku Univ., Sch., Med., Professor, 医学部, 教授 (90022821)

Co-Investigator(Kenkyū-buntansha) CHIBA Toshio  Tohoku Univ., Hp., Lecturer, 医学部・附属病院, 講師 (20171944)
SASAKI Iwao  Tohoku Univ., Sch., Med., Associate Professor, 医学部, 助教授 (60125557)
SASANO Hironobu  Tohoku Univ., Sch., Med., Research Associate, 医学部, 助手 (50187142)
OHTANI Haruo  Tohoku Univ., Sch., Med., Associate Professor, 医学部, 助教授 (30133987)
KIMURA Noriko  Tohoku Univ., Sch., Med., Associate Professor, 医学部, 助教授 (80142975)
Project Period (FY) 1995 – 1997
KeywordsMucosal immune system / Gastro-intestinal mucosa / Neuropeptide / Inflammatory bowel disease / Chronic gastritis / Macrophage / Hypothalamus / Steroid hormone
Research Abstract

The aim of this study is to clarify the mechanism for interations between the neuroendocrine system and the mucosal immune system, and also to understand roles of abnormalities of the neuroendocrine-immune interactions in the pathogenesis of inflammatory and neoplastic disorders in the gastrointestinal mucosa.
1) Urocortin, a neuropeptide of CRF family showing some physiological CRF-mediated actions in vivo, was localized in macrophages is the lamina propria of the intestnial mucosa, and these macrophages were increased in the inflammatory disotders. This suggests that hormons in the PHA axis play a immunoregulatory roles in the gastrointestinal mucosa, together with cytokines.
2) The majority of neurons of the mucosal and submucosal plexus contained VIP,and its mRNA was found in intraepithelial endocrine cells. VIP is known to regulate macrophage funcions as well as water secretion in the intestine. In inflammatory mucosal lesions, distribution of VIP neurons became irregular and decreased in the number. In addition, appearance of VIP receptor on marophages and dendritic cells in the intestiral mucosa deteriorated in the intestinal mucosa from the infants with food allergy combined with atpic dermatitis.
3) Mineralocorticoid receptor and 11beta-hydroxysteroid dehydrogenase type II were expressed in the same cells participating ion and /or water transport including colonic epithelial cells. Their expression disappeared in regenerating cells in the colonic mucosa with ulcerative colitis. This suggests that the disturbance of ion and water vlance in the ulcerative colitis is caused by the absence of their expression.
4) Foveolar epithelial cells of H.pylori-infected gastric mucosa showed some DNA abnormalities incleding apoptosis induced by macrophage and neutropic infiltration. VIP-neurons became irregular and were decreased.

  • Research Products

    (14 results)

All Other

All Publications (14 results)

  • [Publications] 笹野 公伸, 名倉 宏: "Analysis of cell damage and proliferation in Helicobacter pylori-infected human gastric mucosa from patients with gastric adenocarcinoma." Am.J.Pathol.151. 821-829 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 木村 伯子, 名倉 宏: "Plasama chromograin A in pheochromocyatma,catecholamine,parathyroid hormone and pituitary hormones." Endocr.J.44. 319-327 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 大谷 明夫, 名倉 宏: "Expression of costimulatory molecules B7-1 and B7-2 in macrophages and granulomas ofCrohn's disease : Demonstration of cell to cellcontact with T lymphocyces." Lab.Invest.77. 175-184 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 笹野 公伸, 名倉 宏: "Ultrastructural and confocal lase scanning microscopiod examinaion of TUNEL positivisells." J.Pathol.181. 235-242 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 笹野 公伸, 名倉 宏: "Colocalization of 11 β-hydroxysteroid dehydrogenase type II and mineralocorticoidreceptor in human epithelia." J.Clin.Endocr.Metabol.82. 3859-3863 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 笹野 公伸, 名倉 宏: "Immunohistochemical study of DNA topoicomerase II in human gastric disorders." Am.J.Pathol.149. 997-1007 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 名倉 宏、木村 伯子: "Essentials of Mucosal Immunology(分担)" Academic Press, 598 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sasano H,Nagura H.: "Analysis of cell damage and proliferation in Helicobacter pylori-infected human gastric mucosa from patients with gastric adenocarcinoma." Am.J.Pathol.151. 821-829 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kimura N,Nagura H.: "Plasama chromograin A in pheochromocyatma, catecholamine, parathyroid hormone and pituitary hormones." Endocr.J.44. 319-327 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ohtani H,Nagura H.: "Expression of costimulatory molecules B7-1 and B7-2 in macrophages and granulomas of Crohn's disease : Demonstration of cell to cell contact with T lymphocytes." Lab.Invest.77. 175-184 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sasano H,Nagura H.: "Ultrastructural and confocal lase scanning microscopiod examination of TUNEL positivi cells." J.Pathol.181. 235-242 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sasano H,Nagura H.: "Colocalization of 11 beta-hydroxysteroid dehydrogenase type II and mineralocorticoid receptor in human epithelia." J.Clin.Endocr.Metabol.82. 3859-3863 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sasano H,Nagura H.: "Immunohistochemical study of DNA topoisomerase II in human gastric disorders." Am.J.Pathol.149. 997-1007 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nagura H,Kimura N.: Essentials of Mucosal Immunology. Academic Press, 598 (1996)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-03-16  

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