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1996 Fiscal Year Final Research Report Summary

Molecular immnologic studies in the pathogenesis and regulation of autoimmune demyelinating diseases

Research Project

Project/Area Number 07457155
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurology
Research InstitutionShinshu University

Principal Investigator

KOH Shosei  Shinshu University Hispital, Department of Medicine (Neurology), Assistant Professor, 医学部・附属病院, 講師 (80143981)

Co-Investigator(Kenkyū-buntansha) INOUE Atsushi  Shinshu University School of Medicine, Department of Medicine (Neurology), Assoc, 医学部, 助手 (50213145)
Project Period (FY) 1995 – 1996
Keywordsmultiple sclerosis / demyelination / Theiler's virus / antibody / adhesion molecules
Research Abstract

We examined the role of leukocyte function-asociated antigen-1 (LFA-1) and its counter-receptor intercellular adhesion molecule-1 (ICAM-1), one of the most important pairs among adhesion molecules, in the development of Theiler's murine encephalomyelitis virus induced demyelinating disease (TMEV-IDD). Immunohistochemical study showed hyperexpression of ICAM-1 on vascular endothelial cells and LFA-1 on mononuclear infiltrating cells in spinal cord from TMEV infected mice. Treatment with anti ICAM-1 or anti LFA-1 monoclonal antibody showed suppressive effect on developement of demyelinating disease both clinically and histologically. There was downregulation in the CNS of the respective adhesion molecule after treatment. In mice treated with monoclonal antobodies to these adhesion molecules, TMEV specific delayd type hypersensitrvity and the proliferative response of T cells were decreased, and the production of TNFa and IFNg in the spleen cells was decreased and that of IL4 remained unchanged. These data suggest that ICAM-1-LFA-1 pathway is critically involved in the pathogenesis of TMEV-IDD and that antibodies to these adhesion molecules could be a novel therapeutic approach to demyelinating disease such as human multiple sclerosis.

  • Research Products

    (24 results)

All Other

All Publications (24 results)

  • [Publications] Inoue A, et al.: "Anti-adhesion molecule therapy in Theiler's murine encephalomyclitis virus-induced demyelinating disease." Internat Immunol. 9(in press).

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Iwahashi T, et al.: "A study on a new antineural antibody in a case of paraneoplastic sensory neuropathy associated with breast carcinoma." J Neurol Neurosurg Psychiat,. 63. 516-519 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yahikozawa H, el al.: "Major linear antibody epitopes and capsid proteins differentially induce protective immunity against Theiler's virus-induced demyelinating disease." J Virol,. 71. 3105-3113 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yamazaki M, et al: "Phosphatidylserine Suppresses Theiler's murine encephalomyelitis virus-induced demyelinating disease." J Neuroimmunol. 75. 113-122 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Inoue A, Koh C-S, et al.: "Detection of the soluble form of the Fas molecule in patients with multiple sclerosis and human T-lymphotropic virus type I-associated myelopathy." J Neuroimmunol. 75. 141-146 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Inoue A, Koh C-S, et al.: "The fibrin deposition in the central nervous system correlates with thedegree of Theiler's murine encephalomyelitis virus-induced demyelinating disease." J Neuroimmunol. 77. 185-194 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Inoue A, Koh C-S, et al.: "The level of tumor necrosis factor-α producing cells in the central nervous system correlates with the degree of Theiler's murine encephalomyelitis virus-induced demyelinating disease." Intermnat Immunol. 8. 1001-1008 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Inoue A, Koh C-S, et al.: "Suppression of cell-transferred experimental autoimmune encephalomyelitis in defibrinated Lewisrats." J Neuroimmunol. 71. 131-137 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hanaoka T,Fujimori M,Shingu K,Hirose S,Maruyama M,Ito K,Asanuma K,Kasuga Y,Kobayashi S,Iwahashi T,Inoue A,Koh C-S,Matsuyama I,Tsuchiya S,Amano J: "A case of occult breast cancer with paraneoplastic polyneuropathy" Breast Cancer. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Koh C-S,Takahashi K,Kwaan HC: "Two-color fluorescence analysis of fibrin networks from normal and X-ray irradiated fibrinogens and incorporation of fibrinolytic components by a confocal laser-scanning microscopy" Bioimages. 5. 49-58 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Inoue A,Koh C-S,Yamazaki M,Ichikawa M,Isobe M,Ishihara Y,Yagita H,Kim BS: "Anti-adhesion molecule therapy in Theiler's murine encephalomyelitis virus - induced demyelinating disease" Internat.Immunol.9 (in press).

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Iwahashi T,Koh C-S,inoue A,Yanagisawa N: "Tumor necrosis factor-a and trnasforming growth factor-b production by mononuclear cells in the spinal cords of Lewis rats with experimental autoimmune encephalomyelitis" Tohoku J Exp.Med.183. 123-133 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sakurai S,Inoue A,Koh C-S,Ohwa M,Yanagisawa N: "Soluble form of selectins in blood of patients with acute myocardial infarction and coronary intervention" Vascular Medicine. 2. 163-168 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Iwahashi T,A.Inoue, Koh C-S,N.Yanagisawa: "A sutyd on a new antineural antibody in a case of paraneoplastic sensory neuropathy associated with breast carcinoma" J Neurol.Neurosurg.Psychiat.63. 516-519 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sekijima Y,Tokuda T,Hashimoto T,Koh C-S,Shoji S,Yanagisawa N: "Serial magnetic resonance imaging (MRI) study of a patient with Balo's concentric sclerosis treated with immunoadsorption plasmapheresis" Multi Scler. 2. 291-294 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yahikozawa H,Inoue A,Koh C-S,Choe Y-K,Kim BS: "Major linear antibody epitopes and capsid proteins differentially induce protective immunity against Theiler's virus-induced demyelinating disease" J Virol.71. 3105-3113 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yamazaki M,Inoue A,Koh C-S,Sakai T,Ishihara Y: "Phosphatidylserine suppresses Theiler's murine encephalomyelitis virus-induced demyelinating disease" J Neuroimmunol.75. 113-122 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Inoue A,Koh C-S,Sakai T,Yamazaki M,Yanagisawa N,Usuku K,Osame M: "Detection of the soluble form of the Fas molecule in patients with multiple sclerosis and human T-lymphotropic virus type I-associated myelopathy" J Neuroimmunol.75. 141-146 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Inoue A,Koh C-S,Yamazaki M,Yanagisawa N,Ishihara Y,Kim BS: "The fibrin deposition in the central nervous system correlates with the degree of Theiler's murine encephalomyelitis virus-induced demyelinating disease" J Neuroimmunol.77. 185-194 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yamazaki M,Koh C-S,Inoue A,Yanagisawa N: "Comparative study of the efficacy of plasma exchange, immunoadsorption plasmapheresis and corticosteroid administration for the treatment of Guillain-Barre syndrome" Jpn.J Apheresis.16. 204-205 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Inoue A,Tsuyusaki J,Sakai T,Koh C-S,Yanagisawa N,Arakura H,Oguchi H: "Immunoadsorption plasmapheresis in inflammatory demyelinating disease" Jpn.J Apheresis.16. 206-207 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Inoue A,Koh C-S,Yahikozawa H,Yanagisawa N,Yagita H,Ishihara Y,Kim BS: "The level of tumor necrosis factor-Ephi producing cells in the central nervous system correlates with the degree of Theiler's murine encephalomyelitis virus - induced demyelinating disease." Internat.Immunol.8. 1001-1008 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Inoue A,Koh C-S,Yanagisawa N,Taketomi T,Ishihara Y: "Suppression of Theiler's murine encephalomyelitis virus - induced demyelinating disease by administration of gangliosides" J Neuroimmunol.64. 45-53 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Inoue A,Koh C-S,Shimada K,Yanagisawa N,Yoshimura K: "Suppression of cell-transferred experimental autoimmune encephalomyelitis in defibrinated Lewis rats" J Neuroimmunol.71. 131-137 (1996)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-03-16  

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