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1997 Fiscal Year Final Research Report Summary

Selective Vulnerability of neurons in age-related neuronal death and its molecular mechanisms

Research Project

Project/Area Number 07457157
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurology
Research InstitutionDepartment of Neurology, Iwate Medical University

Principal Investigator

TOHGI Hideo  Depatment of Neurology Iwate Medical University Professor, 医学部, 教授 (90155490)

Co-Investigator(Kenkyū-buntansha) TAKAHASHI Satoshi  Department of Neurology Iwate Medical University Iecturer, 医学部, 講師 (50216719)
ABE Takashi  Department of Neurology Iwate Medical University Associate professor, 医学部, 助教授 (30202667)
UTSUGISAWA Kimiaki  Department of Neurology Iwate Medical University Lecturer, 医学部, 助手 (00244913)
Project Period (FY) 1995 – 1997
Keywordsaging / neuron death / selective vulnerability / molecular chaperone / nuclear receptors / dopamine receptor (D_1, D_2) / nicotinic acetyocholine receptor subunits(alpha4, beta2) / ニコチン性アセチルコリン受容体
Research Abstract

To investigate selsctive vulnerability of neurons in age-related neuronal death and its mechanisms, we studied changes with age in mRNA expression of a molecular chaperone (heat0shock cognate 70, hsc 70), neurtransmitter precursors (preprotechykinin and preproenkephalin), neurotransmitter receptors (dopamine D_1and D_<> receptrs), and receptor subunits (nicotinic acetylcholine receptor subunits [nAChR] alpha4 and beta2 )in differing regions (cerebral cortex, hippocampus, and putamen) of human autopsy brains. The results suggest 1) that valnerability of neurons to aging is related to expression of hsc 70, and differs between neurons with differing neurotransmitters.and 2 ) that the magnitude of the reduction with age differs between receptor subtypes for a transmitter (e.g.D_1and D_2) and between receptor subunits (e.g.nAChR alpha4 and beta2) in differing regions.

  • Research Products

    (19 results)

All Other

All Publications (19 results)

  • [Publications] Tohgi H et al: "Heat-shock cognate 70 messenger RNA expression in postmortem human hippocampus: regional difference and age-related changes." Neurosci Lett. 196. 89-92 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tohgi H et al: "Effects of age on messenger RNA expression of glucocorticoid, thyroid hormone, androgen, and estrogen receptors in postmortem human hippocampus" Brain Res. 700. 245-253 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tohgi H et al: "Cerebrospinal fluid acetylcholine and choline in vascular dementira of Binswanger and multiple small infarct types as compared with Alzheimer type dementia." J Neural Transm. 103. 1211-1220 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tohgi H et al: "Reduction in the ratio of β-preprotachykinin to preproenkephalin messenger RNA expression in postmortem human putamen during aging and in patients with status lacunaris. Implications for the susceptibility to parkinsonism" Brain Res. 768. 86-90 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tohgi H et al: "Concentration of catecholamines and indoleamines in the cerebrospinal fluid of patients with vascular parkinsonism compared to Parkinson's disease patients." J Neural Transm. 104. 441-449 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tohgi H et al: "Reduced size of right hippocampus in 39- to 80-year-old normal subjects carrying the apolipoprotein Eε4 allele." Neurosci Lett. 236. 21-24 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tohgi H et al: "Alteration with aging and ischemia in nicotine acetylcholine receptor subunits α4 and β2 messenger RNA expression in postmortem human putamen.Implication for susceptibility to parkinsonism." Brain Res. (in press). (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tohgi H et al: "Age-related changecs in nicotinic acetylcholine receptor subunits α4 and β2 messenger RNA expression in postmortem human frontal cortex and hippocampus." Neurosci Lett. (inpress). (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tohgi H,Utsugisawa K,Yoshimora M,Yamagata M,Nagane Y: "Heat-shock cognate 70 messenger RNA expression in postmortem human hippocampus : regional difference age-related changes." Neurosci Lett. 196. 89-92 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tohgi H,Utsugisawa K,Yamagata M,Yoshimura M: "Effects of age on messenger RNA expression of glucocorticoid, thyroid hormone, androgen, and estrogen receptors in postmortem human hippocampus." Brain Res. 700. 245-253 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tohgi H,Utsugisawa K,Yoshimura M, Yamagata M,Nagane Y,Saito K: "Reduction in the ratio of beta-preprotachykinin to preproenkephalin messenger RNA expression in postmortem humen putamen during aging and in patients with status lacunaris.Implications for the susceptibility to parkinsonism." Brain Res. 768. 90 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tohgi H,Abe T,Kimura M,Saheki M,Takahashi S: "Cerebrospinal fiuid acetylcholine and choline in vascular dementia of Binswanger and multiple small infarct types as compared with Alzheimer type dementia" J Neural Transm. 103. 1211-1220 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tohgi H,Abe T,Saheki M,Yamazaki K,Murata T: "Concentration of catecholamines and indoleamines in the cerebrospinal fluid of patients with vascular parkinsonism compared Parkinson's disease patients." J Neural Transm. 104. 441-449 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tohgi H,Takahashi S,Kato E,Niina R,Sasaki K,Tonezawa H,Sasaki M: "Reduced size of right hippocampus in 39-to 80-year-old normal subjects carring the apolipoprotein E epsilon4 allele" Neurosci Lett. 236. 21-24 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tohgi H,Utsugisawa K,Yoshimura M,Nagane Y,Mihara M: "Alteration with aging and ischemia in nicotinic acetylcholine receptor subunits alpha4 and beta2messenger RNA expression in postmortem human putamenImplication for susceqtibility to parkinsonism" Brain Res. (in press). (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tohgi H,Utsugisawa K, Yoshimura M,Nagane Y,Mihara M: "Age-related changes in D_1 and D_2 receptor mRna expression in postmortem human putamen with and without mutiple small infarcts." Neurosci Lett. (inpress). (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tohgi H,Yonezawa H,Takahashi S,Sato N,Kudo M,Hatano K,Sasaki T: "Cerebral blood and flow and oxygen metabolism in Alzheimer-type dementia compared with vascular dementia with deep white matter changes" Neuroradiology. (in press). (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tohgi H,Utsugisawa K,Yoshimura M,Nagane Y,Mihara M: "Age-related changes in nicotinic acetylcholine receptor subunits alpha4 and beta2 messenger RNA expression in postmortem human frontal cortex and hippocampus." Neurosci Letter. (in press). (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tohgi H,Abe T,Murata T,Isobe C,Ishizaki E: "The cerebrospinal fluid oxidized NO merabolites, nitrite and nitrate in Alzheimer's disease and vascular dementia of Binswanger type and multiple small infarct type." J Neural Transm. (in press). (1998)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-03-16  

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