1996 Fiscal Year Final Research Report Summary
New Risk Factors for Liver Metastasis of Colorectal Cancer
| Project/Area Number |
07457267
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | The University of Tokyo |
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Principal Investigator |
ONO Masaya The University of Tokyo, the 1st dept.of surgery, Instructor, 医学部・附属病院, 助手 (00270900)
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| Co-Investigator(Kenkyū-buntansha) |
YOKOYAMA Tadashi The University of Tokyo, the 1st dept.of surgery, Instructor, 医学部・附属病院, 医員
SASAKI Shin The University of Tokyo, the 1st dept.of surgery, Instructor, 医学部・附属病院, 医員
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| Project Period (FY) |
1995 – 1996
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| Keywords | MMPs / MMP-1 / focal dedifferentiation / sLe (x) / cancer / metastasis |
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| Research Abstract |
The matrix metalloproteinase (MMPs) are a family of closely related enzymes that degrade the extracellular matrix proteins and are considered to be important in facilitating tumor invasion and metastasis. Using immunohistochemistry we investigated the expression of MMP-1 in colorectal carcinomas and its relationship with histopathological factors such as hematogenous metastasis, Dukes classification, lymphonode metastasis, depth of invasion, lumphatic invasion, and venous invasion. We found that the expression of MMP-1 in colorectal carcinoma correlates well with hematogenous metastasis and has a prognotic value independent of other histopathological factors.
We have also investigated the morphological features and the expression of sialyl-Lex in primary lesions of patients with colorectal carcinoma with liver metastasis. Both "focal dedifferentiation" and expression of sialyl Le^x antigen in the primary lesion were found to be good markers for assessing the metastatic proclivity of colorectal cancer.
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