1997 Fiscal Year Final Research Report Summary
Genetic Instability for liver carcinogenesis.
| Project/Area Number |
07457276
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Nagasaki University |
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Principal Investigator |
FURUI Junichiro Nagasaki University, School of Medicine Hospital, Lecturer, 医学部・附属病院, 講師 (30264229)
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| Co-Investigator(Kenkyū-buntansha) |
KANEMATU Takashi Nagasaki University, School of Medicine, Professor, 医学部, 教授 (40128004)
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| Project Period (FY) |
1995 – 1997
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| Keywords | Hepatocellular carcinoma / hepatitis B surface antigen / hepatitis C virus antibody / alpha-fetoprotein |
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| Research Abstract |
We analyzed the clinicopathological factors influencing the serum AFP levels at the time of diagnosis in 114 patients with resected HCC.The proportion of HCC patients with high serum AFP levels (>100 ng/ml) has been steadily decreasing from a rate of 57.2% in 1980 to 33.3% in 1993. Asignificant relationship was noted between the serum AFP levels and the virus marker (p<0.01) based on a multivariate analysis. The proportion of HCC patients with high serum AFP levels was significantly less in anti-HCV-positive HCC patients than in HBsAg-positive HCC patients (p<0.01). The proportion of HBsAg-positive HCC patients has been steadily decreasing from a rate of 48% in 1980 to 15% in 1993. In contrast, the proportion of anti-HCV-positive HCC patients was 69% in 1993. It is thus assumed that the prevalence of anti-HCV-positive HCC patients is recently in creasing, based on the fact that the incidence of HCC patients with high serum AFP levels is decreasing.
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