1996 Fiscal Year Final Research Report Summary

Thymulin activity in the serum samples of human normal subjects and patients with thymoma and the screening of the thymic diseases.

Research Project

Project/Area Number	07457298
Research Category	Grant-in-Aid for Scientific Research (B)
Allocation Type	Single-year Grants
Section	一般
Research Field	Thoracic surgery
Research Institution	Nagoya City University
Principal Investigator	YAMAKAWA Yosuke Nagoya City Univ., Med.Sch., Lecturer, 医学部, 講師 (40148284)
Co-Investigator(Kenkyū-buntansha)	FUKAI Ichirou Nagoya City Univ., Med Sch., Senior Assistant, 医学部, 助手 (10244550)
Project Period (FY)	1995 – 1996
Keywords	bioassay / thymulin / thymoma / thymus
Research Abstract	Thymulin activity was assessed in the serum samples of human normal subjects and patients with thymoma by means of erythrocyte rosette inhibition assay of Dardenne and Bach with minor modification. Thymulin activity in the serum of human normal subjects decreased with age. The levels of thymulin activityy in the serum of patients with thymoma were significantly higher than those of age-matched normal controls. Thymulin activity levels in the serum of patients with thymoma appeared to have no relationship to the clinical stage, histologic characteristics, and the degree of lymphocyte infiltration of thymoma or associated disease. These results suggested that it is available for screening of the diseases in thymuses to measure thymulin activity levels in the serum

(2 results)