1997 Fiscal Year Final Research Report Summary
Analysis of factors affecting placental transfer of anesthetic drugs and umbilical circulation with the delivered human-placenta perfusion model.
| Project/Area Number |
07457363
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Hyogo College of Medicine |
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Principal Investigator |
TASHIRO Chikara Hyogo College of Medicine, Department of Anestheisology, Professor., 医学部, 教授 (20107048)
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| Co-Investigator(Kenkyū-buntansha) |
OKUTANI Ryu Hyogo College of Medicine, Department of Anestheisology, Assistant Professor., 医学部, 講師 (90204122)
MURAKAWA Kazushige Hyogo College of Medicine, Department of Anestheisology, Associate Professor., 医学部, 助教授 (70104263)
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| Project Period (FY) |
1995 – 1997
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| Keywords | placenta / obstetric anesthesia / volatile anesthetics / solubility / oxygen delivery to fetus / cesarean section |
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| Research Abstract |
The human-placenta perfusion study has not been completed because of two reasons : (1)only a small number of placenta were available, (2)its valiability was too short to finish the secheduled protocol. Although we will continue to do this placental model study by improving our methodology, the following two findings were driven out in our project term.
1. The solubilities of various anesthetic agents into several placental perfusion solutions.The solubilities (liquid/gas partition coefficient ; lambda) of volatile anesthetics in plasma substitutes, albumin solution, fat emulsions, perfluorochemical emulsion (FC-43), and aqueous solutions. The order of magnititude of lambda value was halothane>enflurane>isoflurane>sevoflurane in all solutions except FC-43, while lambda values in four anesthetics were almost the same at 5.5. The determination method for propofol was established by using head space sampling.
2. The improvement of placental oxygen transfer to the fetus during cesarean delivery.
(1)Use of sevoflurane anesthesia with 100% oxygen before cesarean section was proved to improve oxygen delivery to fetus without severe fetal depression, prolonged uterine relaxation and increased blood loss.
(2)5% maltose-acetated Ringer solution prior to spinal anesthesia was proved to increase fetal oxygenation with increasing the difference of P50 in hemoglobin dissociation curve between mother and baby (prevention of fetal acidosis).
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