1997 Fiscal Year Final Research Report Summary
The study of mucus hypersecretion in respiratory glands.
| Project/Area Number |
07457398
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Mie University |
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Principal Investigator |
MAJIMA Yuichi Mie University Hospital, Lecturer, 医学部・附属病院, 講師 (60024791)
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| Co-Investigator(Kenkyū-buntansha) |
SHIMIZU Takeshi Mie University Hospital, Lecturer, 医学部・附属病院, 講師 (00206202)
SAKAKURA Yasuo Mie University Faculty of Medicine, Professor, 医学部, 教授 (40024723)
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| Project Period (FY) |
1995 – 1997
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| Keywords | airway / mucus / mucus production / serous cell / mucous cell / goblet cell / 3-D culture / neutrophil |
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| Research Abstract |
1.The intraperitoneal injection of antirat neutrophil antiserum inhibited the endotoxin-induced metaplastic and hypertrophic changes of goblet cells in the rat nasal mucosa. Result suggests that neutrophil elastase and other products of neutrophils may contribute to the goblet cell metaplasia and mucus hypersecretion from goblet cells.
2.The administration of indomethacin or dexamethasone significantly inhibited mucus production of goblet cells induced by endotoxin in rat nasal mucosa. Results suggest that intraepithelial mucus production is partly dependent on arachidonic acid products.
3.We succeeded nasal gland cell culture in three-dimensional (3-D) collagen gel. In this culture nasal gland cells developed gland-like tubules consisted of luminal secretory epithelial cells. Both electron dense (serous) and lucent (mucous) secretory granules coexist in a cultured cell. The nasal gland culture in 3-D gel could be useful for studying the mechanisms of gland cell hyperplasia and hypertrophy resulting in the hypersecretion of respiratory mucus.
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