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1996 Fiscal Year Final Research Report Summary

Treatment of glandma. Role of optic nerve head and cheroidal circulation

Research Project

Project/Area Number 07457410
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Ophthalmology
Research InstitutionUniversity of Tokyo

Principal Investigator

ARAIE Makoto  University of Tokyo, Dept.Ophthalmol., Ass.Prof., 医学部・附属病院(分), 助教授 (00092122)

Co-Investigator(Kenkyū-buntansha) MIYAHARA Miyuki  University of Tokyo, Dept.Ophthalmol., Instructor, 医学部附属病院(分), 助手 (50262134)
Project Period (FY) 1995 – 1996
Keywordsoptic nerve head / B-blocker / Ca_<2+>-blocker / blood flow / rabbit / human
Research Abstract

A quantitative index of tissue blood flow velocity and blood flow measured by laser speckle method (NB) in the optic nerve head (NB_<ONH>) and choroid (NB_<CH>) were determined in experimental animals and normal human volunteers before and after administration of several antiglaucoma drugs which have been clinically used or were under development.
Animal study : In albino rabbits, effects of twice daily 2-3 week instillation of 0.5% betaxolol, a beta-1 blocker, 0.5% timolol, a beta-1,2 blocker, 2% carteolol, a beta-1,2 blocker with intrinsic sympathomimetic activity, 0.25% nipradilol, a beta-1,2 blocker alpha-1 blocking activity, and 0.05% bunazosin, an alpha-1 blocker, were studied. Topical unilateral carteolol increased NB_<ONH> in both eyes, while topical unilateral timolol, betaxolol and nipradilol increased it only in ipsilateral eye. Topical unilateral bunazosin showed no effect in both eyes. Intravenous injection of a calcium antagonist, nilvadipine, nicardipine or semothiazil, increased NB_<CH>, while NB_<ONH> was increased only by nilvadipine. To carry out experiments in monkeys, specially disigned monkey chair was first constructed. In experimental glaucoma monkey eyes, oral planidipine, another calsium antagonist, however, showed no significant effect on NB_<ONH>.
Human study : Twice daily 3-week unilateral instillation of 0.5% carteolol slightly increased NB_<ONH> in both eyes, while that of 0.5% betaxolol slightly increased it only in ipsilateral eye and that of 0.5% timolol showed no effect in both eyes. Oral nilvadipine, but not semothiazil, increased in NB_<ONH> humans.
These results indicate that some beta-blockers can affect optic nerve head circulation when given topically and that some calcium antagonist can increase optic nerve head blood flow, which may have implications in treating glaucoma or in studying pathogenesis of glaucoma.

  • Research Products

    (6 results)

All Other

All Publications (6 results)

  • [Publications] 石井 清,新家 真: "眼科学的実験用のカニクイサル身体保定装置(Monkey chair)の試作及びそれによる覚醒下カニクイサルの眼圧日内変動の検討" 日本眼科学会雑誌. 100. 507-512 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 高田美貴子,沢登公男,他: "KT-210 Nipradilol点眼液の家兎視神経乳頭末梢循環に対する作用" 薬理と治療. 24. 1145-1148 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 玉置泰裕,冨田 憲,他: "交感神経作動薬点眼の人眼視神経乳頭末梢循環に及ぼす影響" 日本眼科学会雑誌. 100. 55-62 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ishii K,Araie M: "Construction of a new monkey chair and IOP fluctvation of unanes the fized monkeys" Nippon Ganka Gakkai Zasshi. 100. 507-512 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takada M,Sawanobori K,et al: "Effect of KT-210.Nipradilol, on ONH circulation in rabbits" Pharmacology and Treatment. 24. 1145-1148 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tamaki Y,Tomika K,et al: "Effect pf sympathetic drug in stillations on human ONH circulation" Nippon Ganka Gakkai Zasshi. 100. 55-62 (1996)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-03-09  

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