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1996 Fiscal Year Final Research Report Summary

The effect of hyaluronic acid on experimental temporomandibular joint osteoarthrosis in the sheep

Research Project

Project/Area Number 07457485
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionGifu University

Principal Investigator

TATEMATSU Norichika  GIFU UNIVERSITY SCHOOL OF MEDICINE,PROFESSOR, 医学部, 教授 (60021474)

Co-Investigator(Kenkyū-buntansha) FUJITSUKA Hideki  GIFU UNIVERSITY SCHOOL OF MEDICINE,ASSISTANT, 医学部・附属病院, 助手 (90262766)
KURITA Kenichi  AICHI-GAKUIN UNIVERSITY SCHOOL OF DENTISTRY,ASSOCIATE PROFESSOR, 歯学部, 助教授 (40133483)
Project Period (FY) 1995 – 1996
Keywordshyaluronic acid / temporomandibular joint / osteoarthrosis / experimental animal model
Research Abstract

Purpose : The purpose of this study was to test the effect of repeated injections of hyaluronic acid (HA) on the sheep model of osteoarthrotic temporomandibular joint (TMJ) disease.
Materials and Methods : Bilateral osteoarthrosis (OA) was induced in the TMJs of six sheep. HA was injected into one joint on 7,10,14,17, and 21 days postoperatively. Normal saline was injected into the contralateral joint. Three sheep were killed at 1 month and 3 at 3 months. The joints were removed and examined macroscopically and histologically. A special scoring system was applied following the modified Mankin's score to evaluate the histologic changes.
Results : The control group showed severe osteoarthrotic changes in the condyle, deviation in form from normal morphology, and marked marrow fibrosis. The HA-treated group showed less deviation from normal condylar morphology. The histologic scores at 1 month were HA 12.6, control 24.2 (p<.001), and at 3 months were HA 6.9, control 18.9 (p<.001). There was a significant difference in osteoarthrotic changes between HA-treated and control TMJs, with the HA-treated TMJs having less severe changes.
Conclusion : Repeated intraarticular injections of HA into a sheep TMJ with experimentally induced OA minimizes the extent of osteoarthrotic change when compared with the control joint. Thus, HA may have a role in preventing the progression of TMJ OA.

  • Research Products

    (2 results)

All Other

All Publications (2 results)

  • [Publications] KENICHI KURITA et al: "The Effect of Hyaluronic Acid on Experimental TemporomandibularJoint Osteoarthrosis in the Sheep" J Oral Maxillofac Surg. 55. 1114-1119 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hisashi Neo, Jun-Ichi Ishimaru, Kenichi Kurita, Alastair N.Goss: "The effect of hyaluronic acid on experimental temporomandibular joint osteoarthrosis in the sheep." J Oral Maxillo Surg. 55. 1114-1119 (1997)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-03-16  

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