1996 Fiscal Year Final Research Report Summary
Structure and function of Sec factors involving protein translocation
| Project/Area Number |
07458148
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Structural biochemistry
|
|---|
| Research Institution | University of Tokyo |
|---|
Principal Investigator |
TOKUDA Hajime University of Tokyo, Institute of Molecular and Cellular Biosciences, Professor, 分生細胞生物学研究所, 教授 (40125943)
|
|---|
| Project Period (FY) |
1995 – 1996
|
| Keywords | Protein translocation / Prokaryote / Reconstitution / SecY / SecE / SecG / SecA |
|---|
| Research Abstract |
Efficient protein translocation machinery was reconstituted from SecA,SecY,SecE and SecG into proteoliposomes. SecG was found to undergo the inversion cycle of membrane topology during protein translocation. This cycle was found to be coupled with the membrane insertion and deinsertion cycle of SecA.
|
