1996 Fiscal Year Final Research Report Summary
Study on the long-lasting potentiation of ocular converqence.
| Project/Area Number |
07458219
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
神経・脳内生理学
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| Research Institution | NIIGATA UNIVERSITY |
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Principal Investigator |
BANDO Takehiko Niigata University School of Medicine, Department of Physiology, Professor, 医学部, 教授 (50029534)
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| Project Period (FY) |
1995 – 1996
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| Keywords | ocular convergence / long-lasting potentiation / cat / extrastriate cortex / glutamate blockers / visual stimulation / intracortical stimulation / lateral suprasylvian cortex |
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| Research Abstract |
Amplitudes and velocities of converqence eye movement were increased for 6-24 hours after 30-50 trials (20-30 min) of combined visual and intracortical stimulation in alertand trained cats. Necessary surgeries were performed in advance under deep nembutal anesthetic. In these surgeries, an adapter for a head holder, a chamber for electrode penetration, and eye coils were implanted. Movement of a visual target approached to the cat under computer control was used for visual stimulation. Eyemovement was measured by a magnetic serach coil system. Effective sites for intracortical microstimulation to induce long-lasting potentiation of ocular convergence in combination with visual stimulation were limined in the convergence-related regions in the lateral suprasylvian (LS) visual cortex, reported by Toda et al.(1991). Combination of two stimuli with random intervals or with longer intervals of 4 sec were ineffective to induce long-lasting potentiation, supporting the essential requirement of combination of visual and intracortical stimulation.
Long-lasting potentiation of ocular convergence was inhibited by iontophoretic injection of CNQX (a blocker of AMPA-type glutamate receptor), AP5 (a N-MDA blocker) and H7 (a protein kinase inhibitor). The former is known to block visual responses of LS neurons, and the latter two drugs has been related to synaptic long-term potentiation.
From these results it is concluded that the mechanisms in the LS cortex are responsible for long-lasting ocular convergence. It is also suggested that long-lasting potentiation of ocular convergence shares some basic mechanisms with synaptic long-term potentiation.
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[Publications] Bando, T., Toda, H., Takagi, M., Hara, N.and Yoshizawa, T.: "Contribution of the lateral suprasylvian cortex in occular convergence in the cat." In "Extrageniculostriat Mechanisms Underlying Visually-Guided Orientation Behavior", Progress in Brain Research, Elsevier, Amsterdam. 143-157 (1996)
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「研究成果報告書概要(欧文)」より
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[Publications] Bando, T., Hara, N., Takagi, M., Hasebe, H., Toda, H.: "Vergence eye movement and lens accommodation : cortical processing and neuronal pathway." Proceeding of the first international symnposium on the vergence and accommodation, Stockholm, Sep.16-18 (1996)
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[Publications] Bando, T., Toda, H., Ando, T., Tsubouchi, T., Ibaraki, K., Yamamoto, K.and Hasebe, H.: "Effects of glutamate blockers on the prolonged potentiation of ocular convergence eyoked by pairing visual stimuli with microstimulation of the extrastriate cortex in the cat." Abstracts, 4th IBRO world Congress of Neuroscience. 337 (1996)
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「研究成果報告書概要(欧文)」より
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[Publications] Toda, H., Tsubouchi, T., Ando, T., Hasebe, H., Ibaraki, K., Yamamoto, K.and Bando, T.: "Long-term potentiation of convergence eye movement related to the extra-striate cortex in the cat" Abstracts, "Extrageniculostriate Mechanisms Underlying Visually-guided Orientation Behavior".
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「研究成果報告書概要(欧文)」より
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[Publications] Toda, H., tsubouchi, T., Ando, T., Ibaraki, K., Hasebe, H.and Bando, T.: "Effect of protein kinase inhibitors injected locally into the cat extrastriate cortex on prolonged potentiation of ocular convergence." Jpn.J.Physiol.45(S1). S184 (1995)
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「研究成果報告書概要(欧文)」より
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[Publications] Tsubouchi, T., Toda, H., Ando, T., Ibaraki, K., Hasebe, H., Miki, A.and Bando, T.: "The contribution of the extrastriate cortex to prolonged potentiation of ocular convergence induced by paired visual and intracortical stimulation." Neurosci.Res.S19. S174 (1994)
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「研究成果報告書概要(欧文)」より
