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1996 Fiscal Year Final Research Report Summary

Elucidation of Adaptive Multimode Lubrication, Deterioration and Restoration in Natural Synovial Joints

Research Project

Project/Area Number 07458237
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Biomedical engineering/Biological material science
Research InstitutionKYUSHU UNIVERSITY

Principal Investigator

MURAKAMI Teruo  Kyushu University, Faculty of Engineering, Department of Intelligent Machinery and Systems, Professor, 工学部, 教授 (90091347)

Co-Investigator(Kenkyū-buntansha) MOHTAI Masaaki  Kyushu University, Faculty of Medicine, Department of Orthopaedic Surgery, Resea, 医学部, 助手 (80202357)
MIURA Hiromasa  Kyushu University, Faculty of Medicine, Department of Orthopaedic Surgery, Lectu, 医学部, 講師 (10239189)
HIGAKI Hidehiko  Kyushu University, Faculty of Engineering, Department of Intelligent Machinery a, 工学部, 助手 (00238263)
OHTSUKI Nobuo  Kyushu Univer sity, Faculty of Engineering, Graphic Science, Associate Professor, 工学部, 助教授 (60127991)
Project Period (FY) 1995 – 1996
KeywordsNatural Synovial Joints / Adaptive Multimode Lubrication / Synovia Constituents / Boundary Lubrication / Chondrocyte / Response of Cell to Mechanical Stimulation / Langmuir-Blodgett Method / Cytokine
Research Abstract

The object of this research is to elucidate the adaptive multimode lubrication mechanism in natural synovial joints and to clarify its relation to degradation and restoration.
The systematic investigation was performed to elucidate the adaptive multimode lubrication in natural synovial joints. Experimental evaluation of fluid film formation in knee joint model in simulator and numerical analysis showed the important role of elastohydrodynamic lubrication during walking. Impact tests of synovia and articular cartilage exhibited the existence of protecting film of proteins, particularly gamma-globulin after testing and impact-induced electrical phenomena of cartilage. In friction tests of pig shoulder joints by pendulum method, the influence of hyaluronate concentration on frictional behavior under high and low load conditions was clarified in related to effect of added proteins. The boundary lubrication by adsorbed film composed of phospholipids and proteins was clearly shown by an increase in friction after removal of adsorbed film. Addition of liposome of phospholipid and protein was effective in lowering of friction. Reciprocating tests of sliding pair of articular cartilage and Langmuir-Biodgett film formed on glass plate indicated the superiority of mixed film of phospholipid and protein to phospholipid film.
The continuous shearing to monolayr of cultured chondrocyte in cone/plate viscometer showed the remarkable increase in interleukin 6 (IL-6). This suggests that the shearing stimulation due to inferior lubrication plays an important role in deterioration and restoration in osteoarthritis.

  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] 中西義孝: "ヒアルロン酸水溶液の潤滑性能に及ぼす電場の効果" 日本機械学会論文集(C編). 598・62. 2359-2366 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T.Murakami: "The Adaptive Multimode Lubrication in Biotribological Systems" Proc.of International Tribology Conference,Yokohama. 1981-1986 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] H.Higaki: "The Boundary Lubricating Ability of Proteins in Natural Synovial Joints" Proc.International Tribology Conference,Yokohama. 1987-1992 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 日垣秀彦: "Langmuir-Blodgett法により作成した軟骨表面境界潤滑膜モデルの潤滑性能" 日本機械学会論文集(C編). 62・604. 4684-4689 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 日垣秀彦: "関節潤滑におけるジパルミトイルフォスファチジルコリンリポソームとγグロブリン投与による境界潤滑膜形成の効果" 日本機械学会論文集(C編). 63・606. 543-549 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 村上輝夫: "関節液系溶液の粘性挙動とその関節潤滑における役割" 日本機械学会論文集(C編). 63・607. (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Y.Nakanishi: "Effects of Electric Field on Lubricating Ability of Sodium Hyaluronate Solution" Trans. Jpn. Soc. Mech. Engrs.62-598 C. 2359-2366 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.Murakami: "The Adaptive Multimode Lubrication in Biotribological Systems" Proc. of International Tribology Conference, Yokohama. 1981-1986 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H.Higaki: "The Boundary Lubricating Ability of Proteins in Natural Synovial Joints" Proc. of International Tribology Conference, Yokohama. 1987-1992 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H.Higaki: "Lubricating Ability of Langmuir-Blodgett Films as Boundary Lubricating Films on Articular Surfaces" Trans. Jpn. Soc. Mech. Engrs.62-604 C. 4684-4689 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H.Higaki: "Lubricating Effect of Boundary Films Forned by Addition of Liposomes of Dipalmitoyl Phosphatidylcholine and gamma-Globulin in Synovial Joints" Trans. Jpan. Soc. Mech. Engrs.63-606 C. 543-549 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.Murakami: "Viscous Property of Synovial Fluids and Related Solutions and Its Role in Joint Lubrication" Trans. Jpn. Soc. Mech. Engrs.63-607 C. (1997)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-03-09  

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