1996 Fiscal Year Final Research Report Summary
Integrated-optic biomedical sensing device with a high-resolution optical probe
| Project/Area Number |
07555018
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 試験 |
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| Research Field |
Applied optics/Quantum optical engineering
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| Research Institution | Osaka University |
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Principal Investigator |
HARUNA Masamitu Osaka University, Fac.Medi., Dept.Allied Health Sci., Professor, 医学部, 教授 (20029333)
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| Co-Investigator(Kenkyū-buntansha) |
OHMI Masato Osaka University, Fac.Medi., Dept.Allied Health Sci., Research Associate, 医学部, 助手 (60273645)
FUJIMURA Masatoshi Osaka University, Fac.Eng., Dept.Electron.Eng., Research Associate, 工学部, 助手 (80263218)
KANOSUE Kazuyuki Osaka University, Fac.Medi., Dept.Allied Health Sci., Professor, 医学部, 教授 (50127213)
NISHIHARA Hiroshi Osaka University, Fac.Eng., Dept.Electron.Eng., Professor, 工学部, 教授 (00029018)
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| Project Period (FY) |
1995 – 1996
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| Keywords | biological sensing / Integrated-optic device / Low coherence interferometry / High-resolution optical probe / LiNbO3 optical waveguide |
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| Research Abstract |
The research has been made to realize a high-resolution optical sensing system for detection/imaging of inner structure of biological tissue. In particular, our effort has been focused in development of a compact sensing device/system utilizing the integrated-optic or micro-optic technique.
1.We proposed and demonstrated a novel technique for simultaneous measurement of refractive index n and thickness t of a measured object. The technique is based on the low coherence interferometry combined with precise translation stages. It is applicable for accurate measurement of refractive index of biological tissue, leading to measurement of geometrical dimensions of tissue with an accuracy of mum.
2.Birefringence of biological tissue was also demonstrated. Moreover, we demonstrated for the first time measurement of phase and group indices, separately, taking the wavelength dispersion of index into account.
3.Optics-in-space is required for precise measurement of geometrical dimensions of tissue, and therefore, the low coherence interferometer consisted of micro-optic components on a breadboard of 30 x 30cm^2. The measurement accuracy was below 0.3% when the thickness t > 1mm.
4.The integrated-optic sensing device was also designed and tested, including the directional-waveguide-coupler type of wavelength multiplexer/demultiplexer with a spacing of > 20nm and the single-side-band (SSB) modulator with a extinction ratio of > 20dB.A packaging technique of the waveguide device is really required to develop a practical sensing device.
5.In addition, the spectroscopic technique was developed to analyze functions of biological tissue.
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