1996 Fiscal Year Final Research Report Summary
Study on the environmentally-suitable synthesis of plant conservation materials and medicines
| Project/Area Number |
07555282
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 試験 |
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| Research Field |
有機工業化学
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| Research Institution | Okayama University |
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Principal Investigator |
TSUBOI Sadao Okayama University, Faculty of Environmental Science and Technology, Professor, 環境理工学部, 教授 (00032954)
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| Co-Investigator(Kenkyū-buntansha) |
NAKASHIMA Shuhei Faculty of Agriculture, Okayama University Associate Professor, 農学部, 助教授 (10100950)
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| Project Period (FY) |
1995 – 1996
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| Keywords | plant conservation material / bakers' yeast / lipase / optically active compound / biological catalyst / medicine / antitumor compound / highly selective reaction |
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| Research Abstract |
In this project, we suceeded in the syntheses of chiral alcohols, epoxides, and gamma-butenolides with high optical purities from readily-available starting materials by using environmentally-suitable materials such as bakers' yeast and hydrolysis enzyme, lipase.. Furthermore, plant conservation materials such as insect pheromones and plant hormones, medicines, and their key-intermediates were synthesized from products described above, and biological activities of their synthesized materials are under investigaiton. Major results are summarized as follows :
1. Optically active malic acid, which is a useful key-intermediate in the synthesis of natural products, was synthesized.
2. Optically active 3-chloro-2-hydroxyalkanoates were synthesized, and the total synthesis of (-) -disparlure was established.
3. Both enantiomers of gamma-butenolides were synthesized with high selectivity, and these were applied for the syntheses of (3aS,6aS) -ethysolide, whisky lactone, and (-) -avenaciolide.
4. Optically active alpha-hydroxyaldehydes and glycidic esters, which are useful key-intermediates for the synthesis of pestalotin, accelating the growth of plants, were synthesized.
5. Flourine analog of methyl (Z) -5-tetradecenoate, a sex pheromone of soybean beetle was synthesized.
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