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1997 Fiscal Year Final Research Report Summary

Development of High Sensible Micuro-Glucose Sensor for Long-Term Implantation in Subcutaneous Tissue

Research Project

Project/Area Number 07555560
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section展開研究
Research Field 生物・生体工学
Research InstitutionShizuoka University

Principal Investigator

SUDOH Masao  Shizuoka University, Faculty of Engineering, Professor, 工学部, 教授 (80154615)

Co-Investigator(Kenkyū-buntansha) SUZUKI Tatsuo  Nikkiso Ltd.Shizuoka Work, Senior Researcher, 静岡製作所, 主事
KIMURA Taizo  Hamamatsu University, School of Medicine, Associate Professor, 第一外科, 助教授 (80114461)
HARADA Yukio  Hamamatsu University, School of Medicine, Professor, 第一外科, 教授 (00010380)
KIMURA Motohiko  Shizuoka University, Faculty of Engineering, Assistant Professor, 工学部, 講師 (20195382)
Project Period (FY) 1995 – 1997
KeywordsGlucose Sensor / Linearity Relationship / Design of Membranes / Modulus M_G / Oxygen Tension / Subcutaneous Tissue / 荷電膜 / 交換吸着
Research Abstract

Micro-glucose sensor for sensing glucose level in subcutaneous tissue was prepared and tested in vitro and in vivo. Glucose sensor consists of four membranes, which are a glucose sensible membrane, a semi-permeable membrane, a permselective membrane and a biocompatible membrane. The objective of this paper is to clarify a design of the sensor membranes and to develop a high sensible micro-glucose sensor for implantation in subcutaneous tissue. A theoretical analysis was made by considering laminated membranes of a glucose membrane and a permselective. When a sensor has high permselectivity of Oxygen to glucose, the larger value of M_G improved the more linearity relationship between output current and glucose concentration was. In order to monitor glucose level under low oxygen tension of 5% like subcutaneous tissue, the sensor was dip coated with 3% polyurethane solution in 98% tetrahydrofuran-2% dimethylformamide. The calibration curve of in uitro showed a linear relationship with glucose level over 500 mg・dL^<-1>, when sensor was covered with glucose sensible membrane which M_G was 0.8 and polyurethane membrane as permselective membrane. Output of the sensor was about 10nA/100mg・dL^<-1>-glucose. Glucose level in subcutaneous tissue was monitored continuously up to 7 hours by the sensor covered with Nafion as a biocompatible membrane.

  • Research Products

    (23 results)

All Other

All Publications (23 results)

  • [Publications] 須藤 雅夫: "メディエーター型簡易血糖値モニターの性能試験" 化学工学シンポジウムシリーズ. 58巻. 42-45 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 須藤 雅夫: "酸素発生型ディスポ-ザブル血糖値モニターの開発とセンサー応答" 化学工学シンポジウムシリーズ. 58巻. 46-49 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 須藤 雅夫: "セラミック分離膜のファウリング現象とその対策(その1)" ケミカルエンジニヤリング. 42巻. 548-554 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 須藤 雅夫: "セラミック分離膜のファウリング現象とその対策(その2)" ケミカルエンジニヤリング. 42巻. 725-734 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 須藤 雅夫: "イオン交換膜の不均質膜内構造と輸送特性" J. ION EXCHANGE. 8巻. 202-213 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 須藤 雅夫: "血糖値測定システム" ケミカルエンジニヤリング. 42巻. 918-924 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 須藤 雅夫: "環境工学" 槇書店, 245 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] M.Sudoh: "Non-homogeneous Intramembrane Structure and Transport Properties of ion-Exchange Membrane" J.ION EXCHANGE. 8. 202-213 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] M.Sudoh: "Effects of Thermal and Concentration Boundary layrs on Vapor Permeation in Membrane distilllation of Aqueous Lithium Bromide Solution" J.Membrane Sci.131. 1-7 (1997)

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      「研究成果報告書概要(欧文)」より
  • [Publications] Y.Matsumoto: "Fouling Phenomana of Ceramic Separation Membranes and Their Controls (Part1)" Chem.Eng.42. 548-554 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Y.Matsumoto: "Fouling Phenomana of Ceramic Separation Membranes and Their Controls (Part2)" Chem.Eng.42. 725-734 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] M.Sudoh: "Performance Test of Disposable Monitor of Blood Glucose using Mediatior" Chem.Eng.Symposium Series.Vol.58. 42-45 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] M.Sudoh: "Development and Analysis of Sensor Output of Disposable Monitor of Blood Glucose with Oxygen Pregeneration" Chem.Eng.Symposium Series.Vol.58. 46-49 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] M.Sudoh: "Monitoring System of Blood Glucose" Chem.Eng.42. 918-924 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.Hibino: "Effects of Holdups of Gas and Liquid Phases in Packed-Bed Electrode on Current Efficiency of Electrochemical Production of Hydrogen Peroxide" Denki Kagaku. 65. 1091-1096 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] M.Sudoh: "Transport Properties of Acrylic Acid or Fluoro-sulfonate Charged-Membranes Prepared by Low Temperature Plasma Polymerization" J.Soc.Fiber Sci.& Tech.Jpn. 52. 110-115 (1996)

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      「研究成果報告書概要(欧文)」より
  • [Publications] M.Sudoh: "In-situ Evaluation of Protein Adsorption on Polymer films Coated over Piezoelectric Quartz Resonators" Membrane. 21. 74-81 (1996)

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      「研究成果報告書概要(欧文)」より
  • [Publications] M.Sudoh: "Comparison among Conductivity Measurements of an Ion-exchange Membrane" J.Sea Water Soc.Jpn. 49. 341-346 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] M.Sudoh: "Evaluation of Ionic Transport of Charged Membranes Prepared by Plasma Polymerization" Membrane Symposium. No.7. 125-128 (1995)

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      「研究成果報告書概要(欧文)」より
  • [Publications] S.Itoi: "Recent Trend on Ion-exchange Membrane Technology (I)" J.Sea Water Soc.Jpn. 49. 3-21 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S.Itoi: "Recent Trend on Ion-exchange Membrane Technology (II)" J.Sea Water Soc.Jpn. 49. 280-305 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] M.Sudoh: "Comparison between Output Linearlities of Oxygen Detector and Hydrogen Peroxide Detector for Amperometric Glucose Ssnsor" J.Chem.Eng.Jpn. 28. 816-822 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] M.Sudoh: "Development of Micro-Dialysis Method for Monitoring Bolld Glucose in Subcutaneous Tissue" Chem.Eng.Symposium Series. Vol.55. 13-16 (1995)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-03-16  

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