1996 Fiscal Year Final Research Report Summary
DEVELOPMENT OF ULTRASONIC HYPERTHERMIA SYSTEM FOR MALIGNANT TUMOR IN SMALL ANIMALS
| Project/Area Number |
07556122
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 試験 |
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| Research Field |
Applied veterinary science
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| Research Institution | KOBE UNIVERSITY |
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Principal Investigator |
KONDO Takashi KOBE UNIVERSITY,SCHOOL OF MEDICINE ASSISTANT PROFESSOR, 医学部, 講師 (40143937)
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| Co-Investigator(Kenkyū-buntansha) |
SANO Takayuki SHIMADZU CORPORATION MEDICAL SYSTEM DIVISION INVESTIGATOR, 医用技術部, 研究員
TAKAYAMA Naohiko SHIMADZU CORPORATION MEDICAL SYSTEM DIVISION SENIOR INVESTIGATOR, 医用技術部, 主任研究員
TOYOSAWA Kei-ichiro KOBE UNIVERSITY FACULTY OF AGRICULTURE PROFESSOR, 農学部, 教授 (70032084)
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| Project Period (FY) |
1995 – 1996
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| Keywords | ULTRASOUND / HYPERTHERMIA / THERMAL EFFECTS / NON-THERMAL EFFECTS |
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| Research Abstract |
Hyperthermia induced by ultrasound has been employed as a modality for cancer therapy because of the feasibility of penetration and focusing. Therefore, ultrasonic hyperthermia system for malignant tumor in small animals has been developed. This system consists of a ultrasonic generator, data accumulation system, temperature measurement system, a circulator with temperature controller and degassing system. This system has an applicator equipped with a non-focused ultrasound transducer or a focused one. Two dimensional temperature distributions for the phantom after heating were measured by using agar-graphite mixture phantom. Homogeneous heating pattern from 1 to 4 cm diameter with 2 cm depth was obtained when a frequency of 1.5 MHz was used. A chemical dosimeter utilizing the Weissler reaction (determination of iodine from potassium iodide due to ultrasonic cavitation) was improved with using trichloroacetic acid and the absorbed-dose distribution was estimated by using a "lattice" vessel consisting of 100 small containers. Enhancement of transdermal drug absorption by non-thermal effects of ultrasound has also been investigated.
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[Publications] S.Fujishiro, M.Mitsumori, Y.Okuno, Y.Magata, Y.Nishimura, M.Hiraoka, T.Sano, T.Marume and N.Takayama: Enhancement of heating efficiency of ultrasound contrast agent in a phantom. In "Proceedings of the 7th International Congress on Hyperthermic Oncology vol.2", edited by C.Francini, G.Arcangeli and R.Cavaliere. Post Graduate School of Medical Physics, 394-395 (1996)
Description
「研究成果報告書概要(欧文)」より
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[Publications] M.Mitsumori, M.Hiraoka, Y.Okuno, Y.Nishimura, S.Fujishiro, Y.Nagata, M.Abe, T.Sano, T.Marume and N.Takayama: In "Proceedings of the 7th International Congress on Hyperthermic Oncology vol.2", edited by C.Francini, G.Arcangeli and R.Cavaliere. Post Graduate School of Medical Physics, 396-398 (1996)
Description
「研究成果報告書概要(欧文)」より
