1996 Fiscal Year Final Research Report Summary
Development and application of a method for non-invasive measurements of local oxygen consumption by near-infrared spectroscopy
| Project/Area Number |
07557007
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 試験 |
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| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
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| Research Institution | SHINSHU UNIVERSITY |
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Principal Investigator |
SAKAI Akio Shinshu Univ., Sports Med., Assoc. Prof., 医学部・加齢適応研究センター・スポーツ医学, 助教授 (70020758)
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| Co-Investigator(Kenkyū-buntansha) |
SAITO Tateo Biomedical Science Co. Dir., バイオメディカル サイエンスKK, 技術部長
YANAGIDAIRA Yasunori Shinshu Univ., Sports Med., Assist. Prof., 医学部・加齢適応研究センター・スポーツ医学, 講師 (10020760)
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| Project Period (FY) |
1995 – 1996
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| Keywords | near-infrared spectroscopy / local oxygen consumption / quadticeps muscle / high altitude / 組織酸素消費量 |
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| Research Abstract |
We have developed a method of non-invasive and continuous measurements of oxygen saturation (St O_2) and absolute volumes of hemoglobin (Hb vol) using near-infrated spectroscopy (NIRS). An instrument (PSA-III N) has been designed for the use of this method so that the tissue surface can be irradiated successively with infrared light of three wavelengths, and the scattered light from the tissue can be measured on the tissue Surface at a point a certain distance away from the irradiated site. St O_2 and absolute values of Hb vol in tissues can be non-invasively determined from the measured absorbance using equations derived from Lambert-beer's law. Oxygen consumption in the tissue (Vt O_2) can then be determined based on the output of PSA-III N.St O_2, Hb vol and Vt O_2 of quadriceps muscles of thigh were measured during exercise using PSA-III N.Changes in St O_2 and Vt O_2 during exercise increased with the load up to a moderate load, while they leveled off at heavier loads. In similar experiments of loaded exercise under conditions of low atmospheric pressure, responses of St O_2 and Vt O_2 were clearly suppressed, and the recovery of Vt O_2 after exercise was delayd. Responses of local muscles generally corresponded to changes in oxygen consumption of the entire body.
From these results, we concluded that the instrument (PSA-III N) offers a means of measuring oxygen conditions of tissues, and may be very useful in basic and clinical medicine.
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