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1997 Fiscal Year Final Research Report Summary

Basic research for the development of the new treatment using endothelin receptor antagonists in cardiovascular diseases

Research Project

Project/Area Number 07557053
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section展開研究
Research Field Circulatory organs internal medicine
Research InstitutionUniversity of Tsukuba

Principal Investigator

SUGISHITA Yasuro  University of Tsukuba Institute of Clinical Medicine Professor, 臨床医学系, 教授 (90010131)

Co-Investigator(Kenkyū-buntansha) GOTO Katsutoshi  University of Tsukuba Institute of Basic Medical Sciences Associate Professor, 基礎医学系, 教授 (30012660)
SAKAI Satoshi  University of Tsukuba Institute of Clinical Medicine Research, 臨床医学系, 助手 (30282362)
MIYAUCHI Takashi  University of Tsukuba Institute of Clinical Medicine Assistant Professor, 臨床医学系, 講師 (60222329)
Project Period (FY) 1995 – 1997
Keywordscardiovascular diseases / endothelin / endothelin antagonist / heart failure / pulmonary hypertension / pharmacology
Research Abstract

Endothelin (ET) is an endothelium-derived potent vasoconstrictor peptide. ET is also produced by non-vascular tissues such as the heart, lungs and kidneys. ET has mitogenic activity on vascular smooth muscle cells and induces hypertrophy of cardiac myocytes. In the present work, we studied pathophysiological roles of ET in the animals with various cardiovascular diseases (pulmonary hypertension, heart failure, cardiac hypertrophy, e.t.c.) using molecular biological and biochemical methods. Furthermore, we studied the effects of ET receptor antagonists on the animals with cardiovascular diseases. The present study suggested that endogenous ET is involved in the progression of cardiovascular diseases such as pulmonary hypertension, heart failure and cardiac hypertrophy, and that an ET receptor antagonist may be a useful drug for these theses.

  • Research Products

    (16 results)

All Other

All Publications (16 results)

  • [Publications] Satoshi, Sakai・et al.: "Inhibition of myocardial endothelin pathway improves long-term survtval in heart failure" Nature. 384. 353-355 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Takashi, Miyauchi・et al.: "Vasoconstriction by endothelin-1 in resistance conduit portions of isolated human mesenteric arteries" European Journal of Pharmacology. 303. 193-196 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Satoshi, Sakai・et al.: "Pulmenary hypertension caused by longestive heart failure is markedly ameliorated by chronic application of an endothelin receptor antago" Journal of the American College of Cardilogy. 28. 1580-1588 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Satoshi, Sakai・et al.: "Endogenous endothelin-1 partilipates in the maintenance of cardiac function in rats with congestive heat failure" Circulation. 93. 1214-1222 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Takashi, Miyauchi・et al.: "Cloning of hamster preproendothelin-2 cONA and its expression in the heart" Journal of Cardio vuscular Pharmacology. 31. S298-S301 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tsutomu, Kobayshi・et al.: "Down regulation of ET_B receptor,but not ET_p receptor,in congestive lung seconclary to heart failure" Life Sciences. 62. 185-193 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 宮内 卓・酒井 俊・杉下 靖郎: "心不全" 篠山,重威, 697 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 宮内 卓・杉下 靖郎・後藤 勝年: "Annual Review循環器1997" 杉本,恒明・松本,昭彦・杉下,靖郎・門間,和夫, 260 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Miyauchi T,Kobayashi T,Yamauchi R,Hoshino T,Sakai S,Kikkawa K,Yabana H,Sugishita Y,Murata S,Goto K.: "Cloning of hamster preproendothelin-1 cDNA and its expression in the heart." Journal of Cardiovascular Pharmacol. 31. S298-S301 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kobayashi T,Miyauchi T,Sakai S,Maeda S,Yamaguchi I,Goto K,Sugishita Y.: "Down-regulation of ET_B receptor, but not ET_A receptor, in congestive lung secondary to heart failure : are marked increases in circulating endothelin-1 partly attributable to decreases in lung ET_B receptor-mediated clearance of endothelin-1?" Life Sciences. 62. 185-193 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sakai S,Miyauchi T,Kobayashi M,Yamaguchi I,Goto K,Sugishita Y.: "Distribution of endothelin-1 in the lung of rats with pulmonary hypertension of different etiology." International Journal of Angiology. 7. 160-164 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kobayashi T,Miyauchi T,Sakai S,Yamaguchi I,Goto K,Sugishita Y.: "Endothelin-converting enzyme and angiotensin-converting enzyme in failing hearts of rats with myocardial infarction." Journal of Cardiovascular Pharmacolog. 31. S417-S420 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sakai S,Miyauchi T,Kobayashi M,Yamaguchi I,Goto K,Sugishita Y.: "Inhibition of myocardial endothelin pathway improves long-term survival in heart failure." Nature. 384. 353-355 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sakai S,Miyauchi T,Sakurai T,Kasuya Y,Ihara M,Yamaguchi I,Goto K,and Sugishita Y.: "Endogenous endothelin-1 participates in the maintenance of cardiac function in rats with congestive heart failure ; Marked increase in endothelin-1 production in the failing heart." Circulation. 93. 1214-1222 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Miyauchi T., Tomobe Y,Ishikawa T,Goto K,Sugishita Y.: "Vasoconstriction by endothelin-1 in resistance and conduit portions of isolated human mesenteric arteries." European Journal of Pharmacology. 303. 193-196 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sakai S,Miyauchi T,Sakurai T,Yamaguchi I,Kobayashi M,Goto K,and Sugishita Y.: "Pulmonary hypertension caused by congestive heart failure is markedly ameliorated by chronic application of an endothelin receptor antagonist : increased expression of endothelin-1 mRNA and endothelin-1-like-immunoreactivity in the lung in congestive heart failure in rats." Journal of the American College of Cardiolog. 28. 1580-1588 (1996)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-03-16  

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