1997 Fiscal Year Final Research Report Summary
Development of Microscopic CT for embryological studies.
| Project/Area Number |
07557080
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 展開研究 |
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| Research Field |
General surgery
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| Research Institution | University of Tsukuba |
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Principal Investigator |
OHKAWA Haruo University of Tsukuba, Institute of Clinical Medicine, Professor, 臨床医学系, 教授 (30009667)
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| Co-Investigator(Kenkyū-buntansha) |
ITOH Hiroyasu 浜松木トニクス筑波研究所, 研究員
AMAGAI Teruyoshi University of Tsukuba, Institute of Clinical Medicine, Lecturer, 臨床医学系, 講師 (50175923)
IKEBUKURO Kenichi University of Tsukuba, Institute of Clinical Medicine, Lecturer, 臨床医学系, 講師 (70251064)
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| Project Period (FY) |
1995 – 1997
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| Keywords | Ano-rectal malformations / 3-D reconstruction / cloaca / embryology / microscopic CT / X-ray CT / monochronous X-ray / Laser Light |
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| Research Abstract |
With 15 years researches we have established our own pig family of ano-rectal malformations and have kept this under the help of the Grant-in-Aid for Scientific Researches. With full amount of embryological specimens with ano-rectal malformations, we have continued the studies on the normal and abnormal devision of cloaca into ano-rectum and urogenital sinus. In anomalous situations, the devision is not completed in both sexes, in making various grade ano-rectal malformations. In comparative embryology, this process of cloacal devision was very important phenomena for vertebrates especially for mammals.
The mammals have got this ability of devision after getting out of water.
We are trying to clarify these phenomena as an embryological story in three-dementional pictures or illustrations. We wanted to make up three demetional pictures without using hundreds of continuous sectioning and staining of embryos. We persued the possibility of microscopic three-dementional CT on many ways of light, laser light, X-ray, monotonous X-ray and so on. There has been great difficulties of deferentiating monotonous tissues of embryo without giving staining or giving great amount of radiologically contrast-making materials as iodine.
The best possibility was Phase-contrast X-ray computed tomography, which had been under study in the Radiological Department of our own University. We are greatly hoping the future Improvement of this technique and we are in the process of co-working at the present tim.
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