Co-Investigator(Kenkyū-buntansha) |
KAWATA Sumio Osaka University Medical School, Professor, 医学部, 助教授 (90183285)
MONDEN Morito Osaka University Medical School, Professor, 医学部, 教授 (00127309)
FUNAKOSHI Hiroshi Osaka University Medical School, Assistant Professor, 医学部, 助手 (40273685)
MATSUMOTO Kunio Osaka University Medical School, Associate Professor, 医学部, 助教授 (90201780)
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Research Abstract |
Invasion and metastasis of tumor cells follows their interaction with stromal cells. Hepatocyte growth factor (HGF) is a mesenchymal- or stromal-derived mediator that affects the growth and the invasiveness of tumor cells. We prepared an antagonistic molecule, designated as HGF/NK4, from partially digested recombinant HGF.HGF/NK4 competitively inhibited the HGF binding to its receptor c-Met, and abrogated the mitogenic, motpgenic, and morphogenic actions of HGF.In addition, HGF/NK4 almost completely suppressed HGF-induced scattering and invasion of tumor cells in vitro. Furthermore, HGF/NK4 drastically inihibited growth, invasion, and metastasis of tumor cells subcutaneously implanted into nude mouse. These results suggest that there is a unique therapeutic potential for HGF/NK4 to prevent tumor invasion and metastasis.
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