1997 Fiscal Year Final Research Report Summary
DRUG DELIVERY SYSTEM BY THE CONTROL OF BLOOD FLOW DISTRIBUTION USING ARTIFICIAL CIRCULATION WITH OSCILLATED BLOOD FLOW
Project/Area Number |
07557309
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Research Category |
Grant-in-Aid for Scientific Research (A)
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Allocation Type | Single-year Grants |
Section | 展開研究 |
Research Field |
応用薬理学・医療系薬学
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Research Institution | Tohoku University |
Principal Investigator |
NITTA Shin-ichi Tohoku University, Institute of Development, Aging and Cancer, Professor, 加齢医学研究所, 教授 (90101138)
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Co-Investigator(Kenkyū-buntansha) |
FUKUTOME Akira Nihon Zeon Corporation, Chief Engineer, 主任研究員
HIYAMA Hirokuni Ebara Corporation, Chief Engineer, 主任研究員
YAMBE Tomoyuki Tohoku University, Institute of Development, Aging and Cancer, Assistant Profess, 加齢医学研究所, 講師 (70241578)
|
Project Period (FY) |
1995 – 1997
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Keywords | Arterial impedance / Physiological resonance / Oscillated blood flow / Liner actuator / Blood flow distribution / Drug delivery system / Left ventricular assistance |
Research Abstract |
High frequency oscillated blood flow is a typical sine-wave blood flow within 10-40 Hz. It has a higher driving frequency compared with the natural heart beats. Oscillated blood flow may be useful for the new type drug delivery system from its unique driving effects. It may be possible to control the blood flow distribution by the control of driving frequency of oscillated blood flow. In this study, hemodynamic parameters were measured and estimated during artificial circulation using oscillated blood flow. Systemic vascular resistance were decreased by the start of vibrating flow pump. It may show the oscillatory effect for vascular tension by the artificial circulation using oscillated blood flow. Left common carotid arterial blood flow rate were increased by the change of driving frequency without the no change of pump output rate. The arterial impedance were estimated in this study. The branch, curve and stenosis are the major origin of reflect wave, and these points are important for the arterial impedance study. Each organ may have the suitable frequency from its physical characteristics, input impedance study may clear these characters. Blood flow distribution may be controlled by the driving frequency of oscillated blood flow, if we can make the suitable driving frequency for the target organ. The appropriate frequency driving for the target organ may generate the physiological resonance. The artificial circulation using high frequency oscillated blood flow may become the one of the new type drug delivery system.
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[Publications] T.Yambe, S.Kobayashi, T.Sonobe, S.Naganuma, S.Nanka, H.Hashimoto, M.Yoshizawa, K.Tabayashi, H.Takayasu, H.Takeda, S.Nitta.: "Nonlinear mathematical analysis of the hemodynamic parameters during left ventricular assistance with oscillated blood flow." Artificial Organs. 21 (7). 625-629 (1997)
Description
「研究成果報告書概要(欧文)」より
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[Publications] T.Yambe, H.Hashimoto, S.Kobayashi, T.Sonobe, S.Naganuma, S.Nanka, H.Matsuki, M.Yoshizawa, K.Tabayashi, H.Takayasu, H.Takeda, S.Nitta.: "Development are evaluation of to tall implantable ventricular assist system using a vibrating flow pump and transcutaneous energy transmission system with amorphous fibers." Heart and Vessels. 12 (suppl 12). 41-43 (1997)
Description
「研究成果報告書概要(欧文)」より
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[Publications] T.Yambe, K.Shizuka, K.Izutsu, T.Sonobe, S.Naganuma, S.Kobayashi, S.Nanka, H.Hashimoto, M.Yoshizawa, K.Tabayashi, H.Takeda, S.Nitta.: "Pulmonary arterial impedance analysis by the use of the oscillated assist flow." Artificial Organs. 21 (7). 751-754 (1997)
Description
「研究成果報告書概要(欧文)」より
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