1996 Fiscal Year Final Research Report Summary
A Novel Agent for Contrast Echocardiography and its Evaluation in a Distinctive Clinical Application.
| Project/Area Number |
07557344
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 試験 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Osaka University |
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Principal Investigator |
BEPPU Shintaro Osaka Univ., Med.School, Professor, 医学部, 教授 (40113500)
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| Co-Investigator(Kenkyū-buntansha) |
FUJIWARA Hideaki Osaka Univ., Med.School, Professor, 医学部, 教授 (90107102)
YAMATODANI Atsushi Osaka Univ., Med.School, Professor, 医学部, 教授 (30116123)
MASUYAMA Toru Osaka Univ., Med.School, Assistant, 医学部, 助手 (70273670)
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| Project Period (FY) |
1995 – 1996
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| Keywords | Ultrasound / Fluorcarbon / Circulation / Contrast media / bubble |
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| Research Abstract |
So far, the contrast echocardiography via peripheral vein has been limited to the right heart. The microbubbles made by a hand agitation method are relatively too large to pass through the pulmonary capillary beds. Therefore, the opacification of the left heart has been a dream for a long time. Afterwards, it was revealed that sonicated human albumin has a lot of small microbubbles under 10 microns which can pass through the pulmonary capillary bed. The left heart is definitely opacified using this agent. But the effect of its opacification is not constant, because the bubble size by home made method is various. With the progression of the myocardial contrast echocardiography, not only qualitative but also quantitative assessment of myocardial perfusion are required. To satisfy such requirements, homogeneous and sized-determined microbubbles are needed. Intravenous myocardial contrast echocardiography has been desired since the initial studies via intracoronary injection. Several attem
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pts have been made. However, the amount of microbubbles flowing into the coronary arteries is too small to opacify the myocardium clearly, even if the left ventricular cavity is opacified excessively. When a contrast agent is injected into the left atrial cavity, the left ventricular wall is opacified well. But the contrast agent in the left ventricular cavity attenuates the echo from the behind significantly. It has been thought to be difficult to opacify the myocardium via intravenous injection using conventional contrast agents, although color-coded image will useful to visualize the low grade opacified ventricular wall. Recently, a quite new contrast agent has been developed. That is the agent with lower boiling point than body temperature and high stability of bubbles in the blood ; which is named QW3600 Injection. The agent consists of fluorocarbon with surfactant. The agent is liquid state under the room temperature, but boils forming microbubbles after injected into the body. Intravenous injection of high dose over 0.5 mg/kg opacified the myocardium clearly in canine experiments. The opacification of the myocardium remained longer after disappearance of the LV cavity opacification, probably because the microbubbles might become bigger during circulation. Some side effects such as hypotension and hypoxemia occurred using high dosage. But this agent is quite promising for intravenous myocardial contrast echocardiography. Less
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Research Products
(4 results)
