1996 Fiscal Year Final Research Report Summary
Development of novel membrane type artificial lung having controlled surface morphology
| Project/Area Number |
07558131
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 試験 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Science University of Tokyo |
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Principal Investigator |
NAGASAKI Yukio Science University of Tokyo, 基礎工学部, 講師 (90198309)
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| Co-Investigator(Kenkyū-buntansha) |
似鳥 嘉昭 旭化成工業(株), ライフサイエンス総合研究所, 主任研究員
片岡 一則 東京理科大学, 基礎工学部, 教授 (00130245)
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| Project Period (FY) |
1995 – 1996
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| Keywords | Artificial lung / Antithrombogenicity / poly (2-hydroxyethyl methacrylate) / block copolymer / Silicon-containing polymers / polymer brush / Gas permselective membrane |
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| Research Abstract |
Organosilicon-containing polystirene/poly (2-hydroxyethyl methacrylate)block copolymers were prepared by an anionic living polymerization technique. The obtained block copolymer showed unique thermodynamic properties. Especially, the block copolymer which possess only 10 mol% of poly (Si-stirene) segment showed very low glass transition temperature (Tg=10ﾟC) though both segments exhibit the fairly high Tgs (150 and 70ﾟC). The high flexibility of the copolymer chain caused extremely high blood compatibility. The obtained block copolymers also shows high gas exchange ability not only dry but also wet conditions due to the introduction of two organosilicon groups in each monomer unit. By construction of this film using this block copolymer on PP microporous membrane, the high performance membrane which possess both blood compatibility and high gas permeability was obtained.
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