1996 Fiscal Year Final Research Report Summary
Research on new paradigms to test patients with brain damage in the association cortices.
| Project/Area Number |
07558293
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 試験 |
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| Research Field |
神経・脳内生理学
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| Research Institution | KYOTO UNIVERSITY |
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Principal Investigator |
MIKAMI Akichika Kyoto University, Primate Research Institute, Professor, 霊長類研究所, 教授 (40027503)
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| Co-Investigator(Kenkyū-buntansha) |
KOJIMA Shozo Kyoto University, Primate Research Institute, Professor, 霊長類研究所, 教授 (70027499)
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| Project Period (FY) |
1995 – 1996
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| Keywords | human subjects / monkey / The association cerebral cortices / brain injury / visual cognition / Memory / attention / Transcranial Magnetic Stimulation |
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| Research Abstract |
The objective of this research is to introduce new paradigms to test patients with brain damage in the association cortices. Paradigms were designed based on the results of animal experiments using monkeys. Since invasive techniques are impossible for human subjects, the functions of the association cortices have been studied in detail in monkeys. In these 25 years, data of such experiment were accumulated. It is now possible to refer such results to disign paradigms for human subjects. Five paradigms were introduced. (1) Simple visual reaching task : With pressing a button, a target cue was presented and a subject touched that target location. (2) Visual delayd reaching task : With pressing a button, a cue stimulus was presented for 1s. Then, after 5s of delay period, target stimuli appeared at all 8 locations. Subject's task is to select and touch the position where the cue stimulus was presented. (3) Attention shift task : With pressing a button two stimuli were presented. One stimulus is positive and the other is negative. The subject's task is to select positive stimulus. After 5 successive correct trials, the other stimulus became positive. After next 5 successive correct trials, a new stimulus set was introduced and reversal of this set was tested. and this process was repeated. (4) Oddity task : With pressing a button, eight stimuli were presented (7 same and 1 different stimuli) and a subject was asked to select different stimulus. (5) Delayd Matching to Sample task : With pressing a button, sample stimulus presented for 1s. After 5s of delay period, 8 stimuli were presented. The subject was asked to select the same stimulus as the sample stimulus. Using these paradigms, it became possible to test the functions of the association cortices more accurately.
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[Publications] Suzuki, T., Kajiura, I., Toda, K., Kii, K., Kubota, K.and Mikami, A.: "New trial to analyze the spatial memory and the attentional shift in patients with prefrontal lobe lesion on findings of their MRI." Abstract of the Congress of the Japanese Rehabilitation Medicine Association. 172 (1996)
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「研究成果報告書概要(欧文)」より
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[Publications] Mikami, A., Ando, I., Kubota, K., Sawaguchi, T., Yoshikawa, E., Kakiuchi, T., Nakamura, K.and Tsukada, H.: "Posterior cortical areas activated during visually-guided GO/NO-GO task : a PET study." Neuroscience Abstract. 22. 401 (1996)
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[Publications] Mikami, A.: Memory of object identity.In : Brain Processes and Memory, edited by Ishawa, K., McGaugh, J.L., Sakata, H., Elsevier, Amsterdam, 414 (1996)
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