1996 Fiscal Year Final Research Report Summary
Functional analysis of roles of Pax-1 during vertebral column development
| Project/Area Number |
07670003
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Chiba University, School of Medicine |
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Principal Investigator |
KOSEKI Haruhiko School of Medicine, Chiba University ; Assistant, 医学部, 助手 (40225446)
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| Project Period (FY) |
1995 – 1996
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| Keywords | vertebral column / dorsovental axis / Pax-1 / sclerotome / notochord |
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| Research Abstract |
Pax-1 is transcriptional activator containing paired-box as DNA binding domain. From the analysis of Pax-1 deficient mice, Pax-1 was proved to be required for the generation of ventral structures of axial skeleton. To gain further insights for Pax-1 function, I have generated mice over expressing Pax-1 protein. In this mouse, development of caudal vertebral distal region of rib were affected. This result indicates that down regulation of Pax-1 is also important for the morphogenesis of axial skeleton.
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Research Products
(15 results)
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[Publications] Muller, T.S., Ebensperger, C., Neubuser, A., Koseki, H., Balling, R., Christ, B.and Wilting, J.: "Expression of avian Pax1 and Pax9 is intrinsically regulated in the pharyngeal endoderm, but depends on environmental influences in the paraxial mesoderm." Dev.Biol.178. 403-417 (1996)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Akasaka, T., Kanno, M., Balling, R., Mieza, M.A., Taniguchi, M.and Koseki, H.: "A role for mel-18, a Polycomb group-related vertebrate gene, during the anteroposterior specification of the axial skeleton." Development. 122. 1513-1522 (1996)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Wilting, J., Ebensperger, C., Muller, T., Koseki, H., Wallin, J.and Christ, B.: "Pax-1 in the development of the cervico-occipital transitional zone." Anat.Embryol.192. 221-227 (1995)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Ebensperger, C., Wilting, J., Brand-Saberi, B., Mizutani, Y., Christ, B., Balling, R.and Koseki, H.: "Pax-1, a regulator of sclerotome development is induced by notochord and floor plate signals in avian embryos." Anat.Embryol.191. 297-310 (1995)
Description
「研究成果報告書概要(欧文)」より
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