• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

1996 Fiscal Year Final Research Report Summary

Role of the renal sympathetic nerve activity in determining salt sensitivity.

Research Project

Project/Area Number 07670088
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Environmental physiology (including Physical medicine and Nutritional physiology)
Research InstitutionMiyazaki Medical College

Principal Investigator

KANNAN Hiroshi  Miyazaki Med.College, Dept.Physiol., Professor, 医学部, 教授 (00049058)

Project Period (FY) 1995 – 1996
Keywordssalt-sensitivity / renal sympathetic nerve activity / renal sodium excretion / vasopressin / cardiovascular regulation / rat / 心血管反応
Research Abstract

The mechanisms underlying salt-dependent hypertension are not entirely known. Renal sympathetic nerve activity (RSNA) has a direct effect on the control of renal blood flow, renin release and urinary sodium excretion.
1.We have recorded RSNA in free-moving Dahl salt sensitive (DS) and salt-resistant (DR)-rats on a low NaCl diet.
(1) Under resting conditions, two types of discharge patterns were seen, a grouped cardiac-related discharge (GD) and a non-grouped irregular discharge (NGD). The GD was inhibited by i.v.administration of phenylephrine chloride, while the NGD was not. Both GD and NGD were seen in DS and DR rats and both were completely abolished by i.v.administration of the ganglionic blocker, hexamethonium chloride.
(2) l.c.v.infusion of hypertonic NaCl solution significantly increased arterial blood pressure and decreased RSNA compared with the resting levels in both Dahl-R and Dahl-S rats. However, the responsiveness of RSNA to NaCl did not differ in either group. Heart rate did not significantly change.
(3) During 0.3 M NaCl infusion, water intake in Dahl-S rats was diminished compared with that in Dahl-R-rats.
2.Next, using conscious Sprague-Dawley rats, we have examined responsiveness of RSNA in response to central salt loading. The inhibitory response of RSNA following i.c.v.administration of hypertonic NaCl solution were,
(1) greatly attenuated under pentobarbital anesthesia.
(2) enhanced in conscious rats not access to water.
(3) observed in sinoaortic denervated (SAD) conscious rats.
(4) significantly attenuated by pretreatment with vasopressin V_1 antagonist (OPC-21268, i.v.) but not V_2 antagonist (OCP-31260).

  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] Ueta,Y.: "Does recurrent inhibition exist in the paraventricular magnocellular neurosecretory cells in the male rat?" Jpn.J.Physiol.45. 913-919 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kannan,H.: "Inhibition of nitric oxide synthase attenuates osmotic thirst in the rat." Neurobiol.3. 363-370 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kannan,H.: "Activation of symopathetic outflow by recombinant human interleukin-1B in conscious rats." Am.J.Physiol.270. R479-R485 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tanaka,H.: "Biphasic changes in behavioral, endocrine,and sympathetic systems in adjubvant arthritis in Lewis rats." Brain Res.Bull.39. 33-37 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kannan,H.: "Changes in renal sympathetic nerve activities in the regulation of body fluid balance with special reference to central neuropeptides in conscious rats." Jpn.J.Physiol.46. 111-122 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hanamori,T.: "Fiber types of the lingual branch of the trigeminal nerve,chorda tympani,lingual-tonsillar and pharyhgeal branches of the glossopharyngeal nerve,and superior laryngeal nerve and their relation to the cardiovascular responses in rats." Neurosci.Lett.219. 49-52 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ueta, Y., Kannan, H.and Yamashita, H.: "Does recurrent inhibition exist in the paraventricular magnocellular neurosecretory cells in the male rat?" Jpn.J.Physiol.45. 913-919 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kannan, H., Iki, K., Kunitake, T., Shimokawa, A., Saita, M., Ishizuka, Y.and Hanamori, T.: "Inhibition of nitric oxide synthase attenuates osmotic thirst in the rat." Neurobiol. 3. 363-370 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kannan, H., Tanaka, H., Kunitake, T., Ueta, Y., Hayashida, Y.and Yamashita, H.: "Activation of sympathetic outflow by recombinant human interleukin-1beta in conscious rats." Am.J.Physiol.270. R479-R485 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tanaka, H., Ueta, Y., Yamashita, U., Kannan, H.and Yamashita, H.: "Biphasic changes in behavioral, endocrine, and sympathetic systems in adjuvant arthritis in Lewis rats." Brain Res.Bull.39. 33-37 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kannan, H.: "Changes in renal sympathetic nerve activities in the regulation of body fluid balance with special reference to central neuropeptides in conscious rats." Jpn.J.Physiol.46. 111-122 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hanamori, T., Kunitaka, T., Kato, K.and Kannan, H.: "Fiber types of the lingual branch of the trigeminal nerve, chorda tympani, lingual-tonsillar and pharyngeal branches of the glossopharyngeal nerve, and superior laryngeal nerve and their relation to the cardiovascular responses in rats." Neurosci.Lett.219. 49-52 (1996)

    • Description
      「研究成果報告書概要(欧文)」より

URL: 

Published: 1999-03-09  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi