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1996 Fiscal Year Final Research Report Summary

Mechanism of reciprocal control of the autonomic nervous system by VIP-and vasopressin-neurons in the suprachiasmatic nucleus of the hypothalamus

Research Project

Project/Area Number 07670171
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pathological medical chemistry
Research InstitutionOsaka University

Principal Investigator

NAGAI Katsuya  Osaka University, Institute for Protein Research, Professor, たんぱく質研究所, 教授 (70029966)

Project Period (FY) 1995 – 1996
Keywords2-deoxy-D-glucose / hyperglycemia / sympathetic nerve / VIP / vasopressin / somatostatin / receptor / antisense
Research Abstract

Intracranial injection of 2-deoxy-D-glucose (2DG), an inihibitor of glucose utilization, caused hyperglycemia in rats. In this hyperglycemic response, exitations of sympathetic efferents projected to pancreas, liver and adrenal, increases in plasma concentrations of glucagon and adrenaline, and a suppression of the increase in the plasma insulin concentration are involved. In rats with bilateral lesions of the suprachiasmatic nucleus (SCN) and blind rats the hyperglycemic response to intracranial injection of 2DG was not observed. From these facts we examined the role of neurons containing vasoactive intestinal peptide (VIP) in the SCN in these responses because the VIP-neurons receive retinal neural inputs. Consequently, it was observed that the excitation of sympathetic efferents projected to the adrenal and the hyperglycemia elicited by intracranial injection of 2DG were eliminated by bilateral lesions of the SCN and intracranial injection of VIP rescued these responses. Furthermore, it was observed that inhibition of the expression of VIP in the SCN caused by antisense oligodeoxynucleotide to VIP mRNA eliminated the hyperglycemic response due to intracranial injection of 2DG.These facts indicate that neurons containing VIP in the SCN are involved in the mechanisms of the responses to intracranial injection of 2DG.In the SCN there are neurons containing arginine vasopressin (AVP) and somatostatin (SS). It was also observed that intracranial injection of AVP suppressed and that of an AVP-antagonist enhanced the excitation of the sympathetic activity and hyperlgycemia induced by intracranial injection of 2DG,and it was reported that intracranial injection of SS caused similar effects to those elicited by that of AVP.Whether these functions of AVP and SS derives from neurons containing these neuropeptides in the SCN,and if so what is the mechanism of the reciprocal control of the autonomic nervous system due to these neuropeptides are now under investigation.

  • Research Products

    (16 results)

All Other

All Publications (16 results)

  • [Publications] N. Nagai: "Suppressive effect of vasopressin on the hyperglycemic response caused by 2-deoxy-D-glucose" Neuroscience Letters. 190. 187-190 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] N. Komenami: "Continuous infusion of neuropeptide Y in the SCN decreases food intake in rats" Neuroreport. 6. 2321-2324 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S. Chun: "Involvement of cerebral neurotensin in hyperglycemic response caused by 2-deoxy-D-glucose in rats" Neuroscience Letters. 201. 191-194 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] N. Nagai: "Role of the suprachiasmatic nucleus and vasoactive intestinal peptide in response of the plasma vasopressin to osmotic challeng" Endocrinology. 137. 504-507 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K. Nagai: "Bilateral lesions of the hypothalamic suprachiasmatic nucleus eliminated sympathetic response to intracranial injection of 2 deoxy-D-glucose and VIP rescued this response" Brain Research Bulletin. 39. 293-297 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K. Shimizu: "An immunotoxin, anti-VIP antibody-ricin A chain conjugate eliminate neurons in the hypothalamic suprachiasmatic nucleus selectively and abolishes the circadian rhythm of water intake" Brain Research Bulletin. 41. 369-378 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K. Nagai: "Role of suprachiamatic nucleus VIP neurons in the central regulation of blood glucose. In : Liver Innervation" John Libbey, London, 185-191 (7) (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K. Nagai: "SCN output drives autonomic nervous system. In : Hypothalamic Integration of Circadian Rhythms. (Progress in Brain Research, Vol. 111)" Elsevier Science Publisher, Amsterdam, 253-272 (10) (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] N.Nagai, K.Nagai, K.Takezawa, Soo-Jin Chun and H.Nakagawa: "Suppressive effect of vasopressin on the hyperglycemic response to intracranial injection of 2-deox-D-glucose" Neuroscience Letter. 190. 187-190 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] N.Komenami, K.Nagai and L.Thibault: "Cotinuous infusion of Neuropeptide Y in the SCN decreases food intake in rats" NeuroReport. 6. 2321-2324 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Soo-Jin Chun, A.Niijima, K.Shimizu, K.Nagai: "Involvement of cerebral neurotensin in hyperglycemic response caused 2-deoxy-D-glucose in rats" Neuroscience Letters. 201. 191-194 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] N.Nagai, K.Nagai, Soo-JIn Chun, K.Shimizu, K.Takezawa, M.Tsuji, K.Sugahara, and H.Nakagawa: "Role of suprachiasmatic nucleus and vasoactive intestinal peptide in response of the plasma vasopressin to osmotic challenge" Endocrinology. 137. 504-507 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.Nagai, A.Niijima, N.Nagai, H.Hibino, Soo-Jin Chun, K.Shimizu and H.Nakagawa: "Bilateral lesion of the hypothalamic suprachiasmatic nucleus eliminated sympathetic response to intracranial injection of 2-deoxy-D-glucose and VIP rescued this response" Brain Research Bulletin. 41. 369-378 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.Shimizu K.Nagai and H.Nakagawa: "An immunotoxin, anti-VIP antibody-ricin A chain conjugate eliminate neurons in the hypothalamic suprachiasmatic nucleus selectively and abolishes the circadian rhythm of water intake" Brain Research Bulletin. 41. 369-378 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.Nagai: Role of Suprachismatic Nucleus VIP Neurons in the Cetral Regulation of Blood Glucose. In : T.Shimazu ed., Liver Innervation, John Libbey, London. CRC Press, Bock Rater, 185-191 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.Nagai, N.Nagai, K.Shimizu, S.Chun, H.Nakagawa and A.Niijima: SCN Output Drives Autonomic Nervous System. In : R.M.Buijs et al eds, Hypothalamic Integration of Circdian Rhythms, Progrress in Brain Reserch, vol.111. Elsevier Science Publisher, Amsterdam, 253-272 (1996)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-03-09  

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