• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

1996 Fiscal Year Final Research Report Summary

Pathogenesis and Pathophysiology of ARDS

Research Project

Project/Area Number 07670195
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Human pathology
Research InstitutionTokyo Medical and Dental University

Principal Investigator

MIYAKE Shuji  Tokyo Medical and Dental Univ.Dept of Internal Medicine, Research associate, 医学部, 助手 (50239365)

Co-Investigator(Kenkyū-buntansha) MATSUBARA Osamu  National Defense Medical College, Department of Pathology, Professor, 医学教育部, 教授
Project Period (FY) 1995 – 1996
KeywordsARDS / Basement membrane / Lung fibrosis / Collagen
Research Abstract

Histologic findings of the lung in ARDS represent a time-dependent and stereotypical response ot alveolar injury. DAD is divided into three sequential and overlapping stages : an exudative stage of edema and hemorrhages, a proliferative stage of organization and repair, and a fibrotic stage of end-stage fibrosis. The sequential structural changes of the alveoli are summarized as follows ; 1) Laminin is lost most easily impaired both in the epithelial and capillary basement membrane in the early exudative stage, 2) 7S and type IV collagen in the capillary basement membrane are also injured in the early exudative stage, and recovered in the proliferative stage, 3) 7S and type IV collagen in the epithelial basement membrane are slso impaired in the late exudative stage, and remained impaired even in the proliferative stage, 4) Alveolar epithelium regenerated almost completely in the late exudative stage, but staining for thrombomodulin in the alveolar capillary recovered in the proliferative stage. To KNow the activity of alveolar injury, it is useful to measure serum 7S and type IV collagen that break down from injured alveoli and flow into the blood in patients with ARDS.Various extra-pulmonary lesions such as DIC and ATN are also found in ARDS.Thus, ARDS is not a disease that is limited to the lung but a systemic disease which will be closely related to SIRS and MODS.

  • Research Products

    (15 results)

All Other

All Publications (15 results)

  • [Publications] Y.Yoshizawa,S.Miyake et al.: "A follow-up study of pulmonary function tests, broncho alveslar lavage ceus and humoral and cellular-immunity" J Allergy Clin lmmunal. 96. 122-129 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Y.Yoshizawa,S.Miyake etal.: "Immune responsiveness to in haled antigans in local antibody production in the respiratory tract." Clin Exp lmmunal. 100. 395-400 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] H.Azuura,O.Matsubara et al.: "Different localization of ET-A and ET-B receptors in the hyperplastic vascular wall." J Cardiovas Pharmacol. 25. 802-809 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] O.Matsubara et al.: "Alveolar basement membrane breaks down in diffuse alveolar damage an immunohistochemical study" Pathol Int. 45. 473-482 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Amano,O.Matsubara et al.: "Improvement of the sandwuich ELISA for the deter munation of basement mew brave collagen" Int Hepatol Commun. 4. 1-8 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] O.Matsubara et al.: "The nasal biopsy in the Early diagnosis of wegeuer's granul matosis" Vivchows Archin. 428. 13-19 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 三宅修司ら: "特発性間質性肺炎とその周辺疾患" 東京医学社,東京, 488 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 松原修: "現代病理学大集,補遺1" 中山書店,東京, 261 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Y.Yoshizawa, S.Miyake et al.: "A follow-up study of pulmonary function tests, bronchoalveolar lavage cells, and humoral and cellular immunity in bird fancier's lung." J Allergy Clin Immunol. 96. 122-129 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Y.Yoshizawa, Y.Ohtani, T.Inoue, S.Miyake et al.: "Immune responsiveness to inhaled antigens in local antibody production in the respiratory tract in health and lung diseases." Clin Exp Immunol. 100. 395-400 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H.Azuma, H.Hamasaki, J.Sato, E.Isotani, S.Obayashi, O.Matsubara: "Different localization of ET-A and ET-B receptors in the hyperplastic vascular wall." J Cardiovas Pharmacol. 25. 802-809 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] O.Matsubara, A.Tamura, S.Ohdama, E.J.Mark: "Alveolar basement membrane breaks down in diffuse alveolar damage : an immunohistochemical study." Pathol Int. 45. 473-482 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S.Amano, Y.Ohta, K.Fujiwara, K.Miyake, S.Fujii, T.Yoshida, O.Matsubara, Y.Masuda, T.Hayashi: "Improvement of the sandwich ELISA for the determination of basement membrane collagen complex in sera of patients with chronic liver disease by utilizing the chaotropic ion, NaSCN." Int Hepatol Commun. 4. 1-8 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] O.Matsubara, N.Yoshimura, Y.Doil, A.Tamura and E.J.Mark: "The nasal biopsy in the early diagnosis of Wegener's (pathergic) granulomatosis. Significance of Palisading Granuloma and Leukocytoclastic Vasculitis." Virchows Archiv. 428. 13-19 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S.Ohdama, S.Akagawa, O.Matsubara, and Y.Yoshizawa: "Primary diffuse alveolar septal amyloidosis with multiple cysts and calcification" Eur Respir J. 9. 1569-1571 (1996)

    • Description
      「研究成果報告書概要(欧文)」より

URL: 

Published: 1999-03-09  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi