1996 Fiscal Year Final Research Report Summary
Pathogenesis and Pathophysiology of ARDS
| Project/Area Number |
07670195
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
MIYAKE Shuji Tokyo Medical and Dental Univ.Dept of Internal Medicine, Research associate, 医学部, 助手 (50239365)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUBARA Osamu National Defense Medical College, Department of Pathology, Professor, 医学教育部, 教授
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| Project Period (FY) |
1995 – 1996
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| Keywords | ARDS / Basement membrane / Lung fibrosis / Collagen |
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| Research Abstract |
Histologic findings of the lung in ARDS represent a time-dependent and stereotypical response ot alveolar injury. DAD is divided into three sequential and overlapping stages : an exudative stage of edema and hemorrhages, a proliferative stage of organization and repair, and a fibrotic stage of end-stage fibrosis. The sequential structural changes of the alveoli are summarized as follows ; 1) Laminin is lost most easily impaired both in the epithelial and capillary basement membrane in the early exudative stage, 2) 7S and type IV collagen in the capillary basement membrane are also injured in the early exudative stage, and recovered in the proliferative stage, 3) 7S and type IV collagen in the epithelial basement membrane are slso impaired in the late exudative stage, and remained impaired even in the proliferative stage, 4) Alveolar epithelium regenerated almost completely in the late exudative stage, but staining for thrombomodulin in the alveolar capillary recovered in the proliferative stage. To KNow the activity of alveolar injury, it is useful to measure serum 7S and type IV collagen that break down from injured alveoli and flow into the blood in patients with ARDS.Various extra-pulmonary lesions such as DIC and ATN are also found in ARDS.Thus, ARDS is not a disease that is limited to the lung but a systemic disease which will be closely related to SIRS and MODS.
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