1996 Fiscal Year Final Research Report Summary
The study of characterization and tumor cell origin of natural killer (NK) cell lymphoma.
| Project/Area Number |
07670224
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Fukuoka University |
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Principal Investigator |
SUZUMIYA Junji Fukuoka Univ. Hospital, Instructor, 講師 (70206556)
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| Co-Investigator(Kenkyū-buntansha) |
OHSHIMA Koichi Sch. Med. Fukuoka Univ., Assoc. Prof., 医学部, 助教授 (50203766)
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| Project Period (FY) |
1995 – 1996
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| Keywords | Malignant lymphoma / Nasal lymphoma / NK cell / EB virus / TdT / Lymphoblastic lymphoma / Cutaneous lymphoma |
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| Research Abstract |
1. The majority of nasal lymphoma was considered to be of T cell lineage because of the expression of T cell markers. However, recently we and some researchers showed no rearrangement of T cell receptors (TCRs) genes and the expression of CD56 in the lymphoma and categorized the lymphoma as NK/T cell origin. The NK/T nasal lymphomas have some characteristics of the fetal and adult type of NK cell. The NK/T nasal lymphoma is strongly associated with Epstein-Barr virus (EBV). We analyzed 33 cases with nasal lymphoma and 12 cases with pharyngeal lymphoma and revealed that the nasal NK/T cell lymphoma is the different group from those of nasal B cell, or pharyngeal T- and B-cell lymphomas, because of the expression of CD56 and silent TCR and the monoclonal infection of EBV of the tumor cells with the thistological sharacteristics such as angiocentric and/or angiodestructive patterns, necrosis, polymorphic nuclear contours and azurophilic granules in the lymphoma cells.
2. The newly developed immunostain of terminal deoxynucleotidyl transferase (TdT) on paraffin sections is very useful for the diagnosis of lymphoblastic lymphoma. We detected the presence of lymphoblastic type of NK/T cell lymphoma, confirmed by this method. This lymphoblastic lymphoma is the immature type of the nasal NK/T cell lymphoma and is not associated. with EBV.
3. The NK/T cell lymphoma is found also among the subcutaneous proliferation of tumor cells of large round nuclei, which occasionally demonstrate EBV infection.
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[Publications] Takeshita, M., Akamatsu, M., Ohshima, K., Kimura, N., Suzumiya, J., Kikuchi, M., Okamura, T., Nakayama, J., Imayama, S., Uike, N., Nakayama, H.: "Angiocentric immunoproliferative lesions of the skin show lobular panniculitis and are mainly disorders of large granular lymphocytes." Human Pathology. 26 (12). 1321-1328 (1995)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Takeshita, M., Akamatsu, M., Ohshima, K., Suzumiya, J., Kikuchi, M., Kimura, N., Uike, N., Okamura, T.: "Angiocentric immunoproliferative lesions of the lymph node." American Journal of Clinical Pathology. 106 (1). 69-77 (1996)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Koita, H., Suzumiya, J., Ohshima, K., Takeshita, M., Kimura, N., Kikuchi, M., Koono, M.: "Lymphoblastic lymphoma expressing natural killer cell phenotype with involvement of the mediastinum and nasal cavity." American Journal of Surgical Pathology. 21 (2). 242-248 (1997)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Suzumiya, J., Ohshima, K., Kikuchi, M., Takeshita, M., Akamatsu, M., Tashiro, K.: "Terminal deoxynucleotidyl transferase staining of malignant lymphomas in paraffin sections : A useful method for the diagnosis of lymphoblastic lymphoma." Journal of Pathology. (in press).
Description
「研究成果報告書概要(欧文)」より
