1996 Fiscal Year Final Research Report Summary
The effects of acfirin A in liver generation
| Project/Area Number |
07670565
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | University of Tokyo |
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Principal Investigator |
MINE Tetuya University of Tokyo, Faculty of Medicine, 医学部・附属病院(分), 講師 (20157572)
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| Project Period (FY) |
1996 – 1997
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| Keywords | Activin A / Follistatin / Liver regeneration / activin receptor / partial hepatectomy |
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| Research Abstract |
To determine the role of activin A in liver regeneration, the effects of exogenous follistatin, which blocks the action of activin A,were examined. A single adiministration of follistatin into the portal vein accelerated the initial round of DNA synthesis. Furthermore, we also demonstrated that intravenous administration of follistatin also accumulate in the liver and promotes liver regeneration after partial hepatectomy as well as administration into portal vein. Furthermore, we investigated the characterization of the activin receptor using cultured rat hepatocytes.The results indicate that two classes of activin A binding sites existed in cultured hepatocytes : the high-affinity binding site may represent oligomeric complex of the type I and II receptors and at least part of the low-affinity binding site may represent cell-bound follistatin. The number of activin receptors in hepatocytes was increased after the stimulation with EGF.
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