1996 Fiscal Year Final Research Report Summary
Possibility of new endstopic pbotodynamic therapy with ultrasound.
| Project/Area Number |
07670636
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Fukuoka University |
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Principal Investigator |
TOMITA Akira Fukuoka University, School of Medicine, Assisttant, 医学部, 助手 (20268999)
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| Project Period (FY) |
1995 – 1996
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| Keywords | photodynamin therapy / Photofrin II / endoscopy / Ultrasound / colon 26 / 超音波 |
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| Research Abstract |
Ultrasound has been used extensively over the last decades for medical diagnostics and physical therapy. Recently a number of reports have demonstrated enhanced cytotoxic responses when ultrasound and chemotherapeutic agents are combined.
Enhancement of acute cell killing of colon26 cells by low-level ultrasound in the presence of the photosensitizing drug Photofrin II was examined by the use of ultra-thin ultrasound probe in vitro. The probe has an outer diameter of 2 mm and fits through the instrument channel of a common endoscope. Photofrin II alone showed no significant cell killing effect but ultrasound alone showed a slight that. The combined ultrasound and Photofrin II showed marked cell killing effect.
These results suggest that the possiblity of the new endoscopic photodynamic therapy with ultrasound.
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