1995 Fiscal Year Annual Research Report

虚血性神経細胞死の発現機序と予防薬の開発:ニューロン・グリア相互作用の面から

Research Project

Project/Area Number	07670692
Research Category	Grant-in-Aid for General Scientific Research (C)
Research Institution	Tohoku University
Principal Investigator	中村正三東北大学, 医学部・附属病院, 講師 (80108498)
Co-Investigator(Kenkyū-buntansha)	武田篤東北大学, 医学部, 助手 (70261534) 糸山泰人東北大学, 医学部, 教授 (30136428)
Keywords	ischemia / cytokine / oxdiative stress / antioxidant / neurotrophic factor / inflammation / neuronal death
Research Abstract	平成7年度は当初の研究計画に沿って虚血性神経細胞死の過程で脳内の免疫学的表面マーカーの発現と外来性の炎症反応の惹起の詳細を検討し、それらが選択的神経細胞死と梗塞の両者で大いに異なる事を明らかにした。また、その過程で、アストログリアにストレス蛋白が発現する事を明らかにした。以上の結果は神経細胞の生死がneuron-glia interactionや外来性の免疫・炎症担当細胞によって強く影響されると云う当初の作業仮設を支持するものである。これらの結果は、今後、虚血性神経細胞死を予防するための研究を行う上で重要な基礎データとなる。一方、新たな神経栄養因子として注目されつつあるHB-GAMが海馬CA1細胞に局在していること、及び遅発性神経細胞死に先だって発現が著明に減弱することを明かにし、更に反応性アストロサイトで発現誘導されることを示した。これらはHB-GAMの新たな機能を示唆するものであり、現在進行中のHB-GAM受容体(Syndecan-3)の発現変化の検討と併せて、その治療応用の可能性を示唆している。

Research Products
(9 results)

All Other

All Publications (9 results)

[Publications] Kato, H: "Graded expression of immunomolecules on activated microglia in the hippocampus following ischemia in a rat model of ischmic tolerance" Brain Research. 694. 85-93 (1995)
[Publications] Kato, H: "Rolipram, a cyclic AMP-selective phosphodiesterase inhibitor, reduces neuronal damage following cerebral ischemia in the gerbil" European Journal of Pharmacology. 272. 107-110 (1995)
[Publications] Kato, H: "Immunohistochemical localization of superoxide dismutase in the hippocampus following ischemia in a gerbil model of ischemic tolerance" Journal of Cerebral Blood Flow and Metabolism. 15. 60-70 (1995)
[Publications] Araki, T: "Alteration of 3H hemicholinium-3 binding in the post-ischemic gerbil brain" Neurochemistry. 6. 561-564 (1995)
[Publications] Kato, H: "Inducation of Jun-like immunoreactivity in astrocytes in gerbil hippocampus with ischemic tolerance" Neuroscience Letters. 189. 13-16 (1995)
[Publications] Kato, H: "Immunohistochemical localization of the low molecular weight stress protein HSP27 following focal cerebral ischemia in the rat" Brain Research. 679. 1-7 (1995)
[Publications] Takeda,A.: "Induction of heparin-binding growth-associated molecule expression in reactive astrocytes following hippocampal neuronal injury" Neuroscience. 68. 57-64 (1995)
[Publications] Kato, H.: "Calcium deposits in the thalamus follosing repeated cerebral ischemia and longterm survival in the gerbil" Brain Research Bulletin. 38. 25-30 (1995)
[Publications] Kato, H.: "An immunohistochemical study of heat shock protein-27 in the hippocampus in a gerbil model of cerebral ischemia and ischemic tolerance" Neuroscience. 68. 65-71 (1995)

1995 Fiscal Year Annual Research Report

虚血性神経細胞死の発現機序と予防薬の開発:ニューロン・グリア相互作用の面から

Principal Investigator

中村 正三 東北大学, 医学部・附属病院, 講師 (80108498)

Research Products

[Publications] Kato, H: "Graded expression of immunomolecules on activated microglia in the hippocampus following ischemia in a rat model of ischmic tolerance" Brain Research. 694. 85-93 (1995)

[Publications] Kato, H: "Rolipram, a cyclic AMP-selective phosphodiesterase inhibitor, reduces neuronal damage following cerebral ischemia in the gerbil" European Journal of Pharmacology. 272. 107-110 (1995)

[Publications] Kato, H: "Immunohistochemical localization of superoxide dismutase in the hippocampus following ischemia in a gerbil model of ischemic tolerance" Journal of Cerebral Blood Flow and Metabolism. 15. 60-70 (1995)

[Publications] Araki, T: "Alteration of 3H hemicholinium-3 binding in the post-ischemic gerbil brain" Neurochemistry. 6. 561-564 (1995)

[Publications] Kato, H: "Inducation of Jun-like immunoreactivity in astrocytes in gerbil hippocampus with ischemic tolerance" Neuroscience Letters. 189. 13-16 (1995)

[Publications] Kato, H: "Immunohistochemical localization of the low molecular weight stress protein HSP27 following focal cerebral ischemia in the rat" Brain Research. 679. 1-7 (1995)

[Publications] Takeda,A.: "Induction of heparin-binding growth-associated molecule expression in reactive astrocytes following hippocampal neuronal injury" Neuroscience. 68. 57-64 (1995)

[Publications] Kato, H.: "Calcium deposits in the thalamus follosing repeated cerebral ischemia and longterm survival in the gerbil" Brain Research Bulletin. 38. 25-30 (1995)

[Publications] Kato, H.: "An immunohistochemical study of heat shock protein-27 in the hippocampus in a gerbil model of cerebral ischemia and ischemic tolerance" Neuroscience. 68. 65-71 (1995)

中村正三東北大学, 医学部・附属病院, 講師 (80108498)