1996 Fiscal Year Final Research Report Summary
APOPTOTIC CELL DEATH OF CARDIOMYOCYTES IN VARIOUS HEART DISEASES
| Project/Area Number |
07670765
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | TOKYO MEDICAL & DENTAL UNIVERSITY |
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Principal Investigator |
HIROE Michiaki TOKYO MEDICAL & DENTAL UNIVERSITY,SECOND DEPARTMENT OF MEDICINE,ASSOCIATE PROFESSOR, 医学部, 講師 (80101872)
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| Co-Investigator(Kenkyū-buntansha) |
ITO Hiroshi TOKYO MEDICAL & DENTAL UNIVERSITY,SECOND DEPARTMENT OF MEDICINE,ASSISTANT PROFES, 医学部, 助手 (10232464)
ISHIYAMA Shigeru TOKYO MEDICAL & DENTAL UNIVERSITY,SECOND DEPARTMENT OF MEDICINE
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| Project Period (FY) |
1995 – 1996
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| Keywords | myocyte cell death / apoptosis / myocarditis / myocardial infarction / Fas / Fas ligand / lymphocyte |
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| Research Abstract |
There exist two general types of cell death, necrosis and apoptosis, marked by different morphological and molecular characteristics. The mechanism of the cardiomyocyte dath has been classicaly believed to be necrosis in various heart diseases. Therefore, we examined whether apoptotic cardiomyocyte death occurs in acute fulminant myocarditis and scute myocardial infarction and if so, whether the Fas (CD95)/Fas ligand system is associated with the apoptosis. Nucleosomal DNA fragmentation, the biologic hallmark of apoptosis, was detected in numerous cardiomyocytes of these diseases. The expression of Fas antigen protein was upregulated in some of cardiomyocytes, but not in the control. In myocarditis, the expression Fas ligand mRNA and protein was expressed in some of CD4+and CD8+ T cells. Co-expression of Fas and Fas-L was observed in some infiltrating lymphocytes. These results indicate that there exist apoptotic death of the affected cardiomyocytes and infiltrating lymphocytes in acute fulminant myocarditis and myocardial infarction. It is likely that the apoptosis of cardiomyocytes might be associated with the Fas/Fas-ligand pathway.
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Research Products
(29 results)
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[Publications] Hiroe, M., Ishiyama, S., Hiroe, M., Nishikawa, T., Toyosaki, T., Marumo, H.: "Chroniz myocarditis" Cardiologist. 1 (Japanese). 668-676 (1996)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Hiroe, M., Shimozyo, T., Ito, H., Marumo, H., Nishikawa, T., Ishiyama, S., Kasajima, T., Tanaka, M., Nagata, S.: "Myocardial damage in acute myocarditis." Jyunkanki-senmon-i. 4 (Japanese). 205-212 (1996)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Hiroe, M., Ishiyama, S., Tanaka, M., Shimojyo, T., Ito, H., Nishikawa, T.: "Myocardial cell death in heart failure." Chiryogaku. 30 (Japanese). 1209-1214 (1996)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Ito, H., Adachi, S., Tamamori, M., Fujisaki, H., Tanaka, M., Lin, M., Akimoto, H., Marumo, F.and Hiroe, M.: "Mild hypoxia induces hypertrophy of cultured neonatal rat cardiomyocytes." J.Moll Cell Cardiol. 28. 1271-1277 (1996)
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「研究成果報告書概要(欧文)」より
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[Publications] Amano, J., Hiroe, M., Ohta, Y., Ishiyama, S., Nishikawa, T., Tanaka, H., Sunamori, M., Suzuki, A., Marumo, F., and Miyasaka, M.: "Scintigraphy of intercellular adhesion molecule-1 expression for early detection of lung rejection." J Heart Lung Transpl. 15. 1027-1033 (1996)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Ishiyama, S., Hiroe, M., Nishikawa, T., Abe, S., Ito, H., Shimojo, T., Ozawa, S., Yamakawa, K., Matsuzaki, M., Mohammed, MU., Nakazawa, H., Kasajima, T.and Marumo, F.: "Nitric oxide contribute to the progression of myocardial damage in"
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「研究成果報告書概要(欧文)」より
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[Publications] Shimojo, T., Nishikawa, T., Ishiyama, S., Ikeda, I., Kasajima, T., Marumo, F.and Hiroe, M.: "Participaton of nitric oxide and peroxynitrite in the development of myocardial tissue damage in acute myocardial infarction" Cardiovasc Pathol. (in press). (1997)
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「研究成果報告書概要(欧文)」より
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[Publications] Amano, J., Ishiyama, S., Tanaka, H., Sunamori, M., Suzuki, A., Nishikawa, T., Nagai, R., Marumo, F.and Hiroe, M.: "Facilitated phenotypic modulation of smooth muscle cells in the depelpment of acute allograft vascular rejection" J Thoracic Cardiovasc Surg. (in press). (1997)
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「研究成果報告書概要(欧文)」より
