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1996 Fiscal Year Final Research Report Summary

Studies on Subendocardial Vulnerability to Underperfusion using a Needle-probe CCD microscope

Research Project

Project/Area Number 07670823
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionKawasaki Medical School

Principal Investigator

KAJIYA Fumihiko  Kawasaki Medical School, Medical Engineering, Professor, 医学部, 教授 (70029114)

Co-Investigator(Kenkyū-buntansha) MORITA Koichi  Kawasaki Medical School, Medical Engineering, Research Associate, 医学部, 助手 (20210172)
GOTO Masami  Kawasaki College of Allied Health Professions, Medical Electronics, Associate Pr, 医用電子技術科, 助教授 (50148699)
OGASAWARA Yasuo  Kawasaki Medical School, Medical Engineering, Assistant Professor, 医学部, 講師 (10152365)
TSUJIOKA Katsuhiko  Kawasaki Medical School, Physiolgy, Professor, 医学部, 教授 (30163801)
YADA Toyotaka  Kawasaki Medical School, Medical Engineering, Research Associate, 医学部, 助手 (00210279)
Project Period (FY) 1995 – 1996
Keywordsmyocardial ischemia / subendocardial microvessels / needle-probe CCD microscope / reactive hyperemia / vascular pulsation
Research Abstract

Subendocardium is most vulnerable to underperfusion and ischemia in the myocardium. Growing experimental and clinical evidence suggests that abnormal phasic coronary flow patterns, especially to-and-fro flow motion or coronary slosh phenomenon, are associated with coronary underperfusion. It is conceivable that diameter change of coronary arterioles is associated with the coronary underperfusion and phasic flow pattern. During the past several years, important observations have been made regarding the differences in arteriolar behaviors between subepicardium and subendocardium. Most striking difference is the greater arteriolar pulsation in subendocardium than in subepicardium. Therefore, to understand the cause and effect of abnormal phasic coronary flow pattern in relation to subendocardial underperfusion, it is crucial to evaluate behaviors of both subepicardial and subendocardial arterioles during coronary underperfusion. In the present study, in open-chest anesthetized dogs, a nee … More dle-probe CCD video-microscope was employed to visualize subendocardial microcirculation. In response to a transient cessation of coronary arterial flow and reperfusion (reactive hyperemia) , the percent increase in end-diastolic diameter of subendocardial arterioles was greater than that of subepicardial arterioles. The diastolic-to-systolic vascular pulsation amplitude at the peak flow was greater in the subendocardium than subepicardium. To produce a stable condition of coronary underperfusion, which is known to enhance coronary slosh phenomenon, a newly developed coronary perfusion system was connected to the left main coronary artery. The coronary perfusion pressure could be changed to a preset level. With coronary underperfusion, both subepicardial and subendocardial arterioles showed rapid changes of their diameters, suggesting the presence of quick vascular regulation. Since vasodilation is associated with a greater pulsation in the coronary arterioles, the vasodilatory response of subendocardial arterioles to a coronary underperfusion may contribute to enhance slosh phenomenon and the process of subendocardial ischemia. Less

  • Research Products

    (16 results)

All Other

All Publications (16 results)

  • [Publications] Toyotaka Yada: "Direct in vivo observation of subendocardial arteriolar response during reactive hyperemia" Circulation Research. 77. 622-631 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Toyotaka Yada: "Subendocardial arterioles have larger vasodilatory capacity and pulsation amplitude than suberdocardial ohes" Microcirculation annual 1995. 67-68 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Toyotaka Yada: "The rde of Katp channels and NO on greater adenosine-irduced Suberdocardial vasodilation than subepicardial one" Circulation (Suppl.). 94.8. I-183 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Fumihiko Kajiya: "Temporal and spatial heterogeheity of bload supply to the heart-visualization and interpretation-" Proceedings of the 2nd IMIA-IFMBE International Workshep on Biosignal Interpretation. 1-4 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Masami Goto: "Abrorinal endothelium-mediated regulation of coronary flow and arterioles in hypertension" 1996 IEEE Engineering in Medicine & Biology (CD-RPM)(paper No.307). (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Fumihiko Kajiya: "Vencus outflow from the myocardium and subendocardial venular mechanics-Aralysis by laser Doppler method and needle-probe intravital microscop-" Advances in Cardiovascular Research. (in press). (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Fumihiko Kajiya: "Cardiac Energetics : From Emax to Pressure-Volume Area" Kluwer Academic Publisher, 14 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Fumihiko Kajiya: "Cardiac-Vascular Remodeling and Functional Interaction" Springer-Verlag Tokyo, 12 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Toyotaka Yada et al.: "Direct in vivo observation of subendocardial arteriolar response during reactive hyperemia" Circulation Research. 77. 622-631 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Toyotaka Yada et al.: "Subendocardial arterioles have larger vasodilatory capacity and pulsation amplitude than subendocardial ones" Microcirculation annual 1995. 67-68 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Toyotaka Yada et al.: "The role of K_<ATP> channels and NO on greater adenosine-induced subendocardial vasodilation than subepicardial one" Circulation (Suppl.). 94 (8). I-183 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fumihiko Kajiya: "Temporal and spatial heterogeneity of blood supply to the heart-visualization and interpretation-" Proceedings of the 2nd IMIA-IFMBE International Workshop on Biosignal Interpretation. 1-4 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Masami Goto et al.: "Abnormal endothelium-mediated regulation of coronary flow and arterioles in hypertension" 1996 IEEE Engineering in Medicine & Biology, paper. 307. (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Toyotaka Yada et al.: "Endothelium-dependent and -independent vasodilation in subendocardial arterioles of hypertensive canine hearts" Microcirculation annual 1996. 117-118 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fumihiko Kajiya et al.: Emax and myocardial microcirculation. In : Maertin M.LeWinter, Hiroyuki Suga, Matthew W.Watkins (eds.), Cardiac Energetics : From Emax to Pressure-Volume Area, 129-142 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fumihiko Kajiya et al.: Coronary slosh phenomenon and behavior of intramyocardial microcirculation. In : Yukio Maruyama, Masatsugu Hori, J.S.Janicki (eds.), Cardiac-Vascular Remodeling and Functional Interaction, 309-320 (1997)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-03-09  

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