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1996 Fiscal Year Final Research Report Summary

Quantity, function and genetics of HDL as an indicator of CHD.

Research Project

Project/Area Number 07670827
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionFukuoka University

Principal Investigator

SAKU Keijiro  Fukuoka Univ. School of Medicine, Lecturer, 医学部・第二内科, 講師 (40183371)

Co-Investigator(Kenkyū-buntansha) HANDA Koichi  Fukuoka Univ. School of Medicine, Lecturer, 医学部・第二内科, 講師 (50248514)
SHIRAI Kazuyuki  Fukuoka Univ. School of Medicine, Assist Prof., 医学部・第二内科, 助手 (80268995)
NII Takanobu  Fukuoka Univ. School of Medicine, Lecturer, 医学部・第二内科, 講師 (70228120)
OKABE Masanori  Fukuoka Univ. School of Medicine, Lecturer, 医学部・第二内科, 講師 (70258531)
Project Period (FY) 1995 – 1996
Keywordsapolipoprotein A-I / atherosclerosis / coronary angiography / FER_<HDL> / HDL-C / Gene / polymorphism
Research Abstract

Study 1 : Quantity and Function of High Density Lipoprotein as an Indicator of Coronary
Atherosclerosis Background Most of the cholesterol esterification in plasma takes place in the high density lipoprotein (HDL) fraction. The rate of cholesterol esterification in low density (LDL)-and very low density lipoprotein (VLDL)-depleted plasma, which can be expressed as the fractional esterification rate in HDL (FER_<HDL>), and which reflects the reactivity of HDL to lecithin : cholesterol acyltransferase (LCAT), is an important functional assay of HDL.The aim of the present study was to investigate the role of this functional assay of HDL in coronary atheroscierosis (CA) and to establish the best indicator for CA through the combination of quantitative and functional assays of HDL while considering conventional risk factors. Mehods and Results in a study of case and control subjects [with (CA+, n=185)/without (CA-, n=74) angiographically proven CA], we examined the association between CA and … More serum levels of HDL-cholesterol (C), HDL subfraction-C,apolipoproteins, lipoprotein (a), and FER_<HDL>. Age-and sex-adjusted values of HDL-C,HLD2-C,HLD3-C,apo A-I,and apo A-II were lower and those of lipoprotein (a) and FER_<HDL> were higher in CA+ patints than in CA-patients, but these variables were not associated with the extent of stenosis. A close negative correlation was observed between FER_<HDL> and HDL-C in both CA+ and CA- patients, but a covariance analysis indicated significant interaction between the regression line of FER_<HDL> vs. HDL-C for CA+ patients and that for CA-oatients, suggesting an altered relationship between the quantity and function of HDL in CA+ patients. A logistic regression analysis indicated that an increased odds ratio (relative risk for CA) was associated with increasing values of FER_<HDL>/HDL-C.A three-dimensional analysis of the odds ratio and values of FER_<HDL> and HDL-C indicated that patients with the highest FER_<HDL>/HDL-C value (0.68) had the highest odds ratio (12.6), but patients who had the lowest odds ratio (1.00) were those with high HDL-C and high FER_<HDL> values. The odds ratio was>10 times higher in patients with low HDL-C and middle or high FER_<HDL> values and 2.3 times higher in patients with low HDL-C and low FER_<HDL> values than in patients with high HDL-C and FER_<HDL> values, which suggests that high values of FER_<HDL> play an important role in CA,especially when HDL-C is low. Conclusion The combination of a functional assay of HDL (FER_<HDL>) with a quantitative assay of HDL (HDL-C) can be a potent indicator for caronary atherosclerosis. Less

  • Research Products

    (33 results)

All Other

All Publications (33 results)

  • [Publications] Muntoni S.,Saku K.,et al: "A missense mulation (Thr-BPro) in the lysosomal acid Npase (LAL) gene is present with a high frequency in three different ethnlc populations : lmpact on serum Npoprolein concantrations." Human Genetics. 97. 265-267 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Saku K.,Zhang B.,et al: "Medium-term ellects of betaxolol monotherapy and combination therapy with nitrendipine on llpoprotein and apollpoprotein melabollam in patlents with mlld to moderate assential hypertension." J Human Hypert.10. 263-268 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Bal H.,Saku K.,et al: "Analysis of a new polymorphism in the human apollpoprotein A-I gene : assoclation with serum llpoprotein leveis and coronary heart disease." J Cardlology. 28. 207-212 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Saku K.,Zhang B.,et al: "Effects of bisoprolol ,liainoprii and manidlpine on serum lipids and quality of life,in patlents with essential" Jpn J Clin Experlment Med.73. 1919-1926 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Bal H.,Saku et al: "Polymorphism of the apolipoprotein A-IV gene and lis signiflcance in lipld metaboliam and coroanry heart disease in a Japanese population." Europ J Clin Invest.26. 1115-1124 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Saku K.,Okamoto T.,et al: "Short-term effects of a higy-sucrose dlet on plasma lipld,lipoprotein chotesterol,tissue lipoprotein lipase and hepatio trlglycaride lipase in rats." Artery. 22. 36-48 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Bai H., Saku K., Liu R., Imamura M., Arakawa K.: "Association between coronary heat disease and the apolipoprotein A-I/C-III/A-IV complex in a Japanese population." Human Genetics. 95. 102-104 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Saku K.: "Polymorphism of the apolipoprotein A-IV gene and its significance in lipld metabolism and coronary heart disease in a Japanese population." J Chiyoda Life Insurance Foundation. 40. 110-111 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Saku K., Liu R., Jimi S., Matsuo K., Tamamoto K., Yanagita T., Arakawa K.: "Combined effects of pravastatin and probucol on high-density lipoprotein apolipoprotein A-I kinetics in cholesterol-fed rabbits." Jpn Clrcu J.59. 292-298 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Jimi S., Saku K., Uesugi N., Sakata N., Takebayashi s.: "Oxidized low density lipoptrotein stimulates collagen production in cultured arterial smooth muscle cells." Atherosclerosis. 116. 15-26 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ohta T., Saku K., Takata K., Nakamura R., Ikeda Y., Matsuda I.: "Different effects of subclasses of HDL containing apo A-I but not apo A-I (LpA-I) on cholesterol esterification in plasma and net cholesterol efflux from foam cells" Arterioscler Thromb Vascu Biol.15. 956-962 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Saku K., Zhang B., Jimi S., Bai H., Hirata K., Sasaki N., Liu R., Arakawa K.: "High-density lipoprotein and apolipoprotein A-I deficiency induced by combination therapy with probucol and bezafibrate." Eur J Clin Pharmacol.48. 209-215 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Akasu M., Saku K., Okabe M., Handa K., Matsuo K., Jimi S., Arakawa K.: "A case of pseudoxanthoma elasticum associated with sick sinus syndrome." Int J Anglology. 4. 169-171 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takata K., Saku K., Ohta T., Takata M., Bai H., Jimi S., Liu R., Sato H., Kajiyama G., Arakawa K.: "A new case of apo A-I deficiency showing codon 8 nonsense mutation of the apo A-I gene without evidence of coronary heart disease." Arterioscle Thromb Vasc Biol.15. 1866-1874 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hirata K., Saku K., Jimi S., Kikuchi S., Hamaguchi H., Arakawa K.: "Serum lipoprotein (a) concentrations and apolipoprotein (a) phenotypes in the families of NIDDM patients." Diabetologia. 38. 1434-1442 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Saku K., Liu K., Takeda Y., Jimi S., Arakawa K.: "Effects of lisinopril and bisoprolol on lipoprotein metabolism in patients with mild-to-moderate essential hypertension." Clin Therapeu.17. 1136-1146 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Saku K., Jimi S., Sasaki N., Nii T., Shirai K., Koga N., Arakawa K.: "Reduced coronary vasodilation in patients with familial hypercholesterolemia following intracoronary injection of isosorbide dinitrate." Jpn Circu J.59. 808-814 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Muntoni S., Saku K., Arakawa K., Balestrieri A., Assmann G.: "A missense mutation (Thr-6Pro) in the lysosomal acid lipase (LAL) gene is present with a high frequency in three different ethnic populations : impact on serum lipoprotein concentrations." Human Genetics. 97. 265-267 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ohira A., Saku K., Takeda Y., Tsuda Y., Amemiya T.: "Serum levels of lipids, liporoteins, spolipoproteins and lipoprotein (a) in vasoocclusive retinal disease. (Japanese)" Jpn J Clin Ophthalmol.50. 329-332 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yamada K., Ideishi M., Nii T., Shirai K., Noguchi H., Murakami K., Noda Y., Matsuo K., Handa K,.Okabe M., Saku K., Kawaguchi H., Tanaka K., Arakawa K.: "An analysis of the patients presenting with acute myocardial infarction during a one-year period of 1994. (Japanese)" Med Bull Fukuoka Univ.23. 71-82 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Saku K., Okamoto T., Takeda Y., Jimi S., Zhang B., Bai H., Liu R., Arakawa K.: "Short-term effects of a high-sucrose diet on plasma lipid, lipoprotein cholesterol, tissue lipoprotein lipase and hepatic triglyceride lipase in rats." Artery. 22. 36-48 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Saku K., Zhang B., Okamoto T., Takeda Y., Liu K., Jimi S., Arakawa K.: "Medium-term effects of betaxolol monotherapy and combination therapy with nitrendipine on lipoprotein and apolipoprotein metabolism in patients with mild to moderate essential hypertension." J Human Hypert.10. 263-268 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Oku K., Inoue T., Nomoto J., Takao M., Tahara H., Saku K., Handa K., Arakawa K.: "Evaluation of hemodynamic effects of nitroglycerin on the utility of transesophageal echocardiography for diagnosis of coronary heart disease." Curr Ther Res.57. 366-375 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Bai H., Saku K., Liu R., Jimi S., Arakawa K.: "Analysis of a new polymorphism in the human spolipoprotein A-I gene : association with serum lipoprotein levels and coronary heart disease." J Cardiology. 28. 207-212 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Saku K., Zhang B., Arakawa K.: "Effects of bisoprolol, lisinopril and manidipine on serum lipids and quality of life, in patients with essential hypertension. (Japanese)" Jpn J Clin Experiment Med.73. 1919-1926 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Bai H., Saku K., Liu R., Arakawa K.: "Polymorphism of the apolipoprotein A-IV gene and its significance in lipid metabolism and coroanry heart disease in a Japanese population." Europ J Clin Invest.26. 1115-1124 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Handa K., Takao M., Nomoto J., Oku K., Shirai K., Saku K., Arakawa K.: "Evaluation of the coagulation and fibrinolytic systems in men with intermittent claudication." Anglology. 47. 543-548 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ohta T., Saku K., Nagata N., Matsuda I.: "Fractional esterification rate of cholesterol in high density lipoproteins is correlated with low density lipoprotein particle size in children." J Lipid Res.38. 139-146 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Zhang B., Saku K., Arakawa K.: "Quantification of the effects of troglitazone on insulin sensitivity and beta-cell function in Watanabe heritable hyperlipidemic rabbits : a minimal model analysis" Metabolism. 46. 273-281 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Saku K., Liu K., Takeda Y., Okamoto T., Jimi S., Kikuta T., Miyako H., Arakawa K.: "Gingival overgrowth with calcium channel blocker amlodipine." Med Bull Fukuoka Univ.23. 225-226 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Saku K., Zhang B., Arakawa K.: "Troglitazone lowers blood pressure and enhances insulin sensitivity in Watanabe heritable hyperlipidemic rabbits." Am J Hypertension. (in press). (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Saku K., Nii T., Handa K., Shirai K,Okabe M., Liu R., Zhang B., Ohta T., Arakawa K.: "Quantity and function of high density lipoprotein as an indicator of coronary atherosclerosis." (sent for publication). (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Liu R., Saku K., Jimi S., Ohta T., Takebayashi T., Arakawa K.: "Mechanism of action of gemfibrozil on HDL metabolism and atherosclerosis in WHHL rabbits" (sent for publication). (1997)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-03-09  

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