1996 Fiscal Year Final Research Report Summary
Association analysis of the angiotensinogen gene polymorphism and life style with childhood essential hypertension.
| Project/Area Number |
07670844
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Niigata University |
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Principal Investigator |
UCHIYAMA Makoto Niigata University School of Medicine Professor, 医学部, 教授 (80108050)
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| Co-Investigator(Kenkyū-buntansha) |
HASHIMOTO Naoshi Niigata University School of Medicine Lecturer, 医学部, 講師 (90208455)
TANAKA Atsushi Niigata University Medical Hospital Lecturer, 医学部附属病院, 講師 (60221389)
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| Project Period (FY) |
1994 – 1996
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| Keywords | Child / Essential hypertension / Blood pressure / Angiotensinogen / Gene polymorphism / Life style |
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| Research Abstract |
We detected the angiotensinogen gene variant (AA,Aa, aa) in 131 Japanese children using a polymerase chain reaction. We also measured height, weight, arm cicumference and blood pressure (BP), and set up a questionnaire concerning the life style and heredity for hypertension. Informed consent was obtained from parents to examine the blood chemistry and angiotensinogen gene variants.
The following results were obtained.
1) The genotype frequency of aa was 0.59, and the allele frequecy of a was 0.76. Genotype frequencies were not significantly different from Hardy-Weinberg's equilibrium in these Japanese children.
2) We found no significant relationship between the three genotypes (AA,Aa, aa) and either systolic or diastolic BP.
3) When comparing several variables in children with the aa genotype and the AA + Aa genotypes, systolic BP in children with aa was higher than in those with AA + Aa, although this was not statistically significant.
4) No relationship was found between children's BP and the family history of essential hypertension or their life style.
5) By multiple regression analysis, the genotype was a statistically significant independent factor of systolic BP.
Thsese findings suggest that this molecular variant of the angiotensinogen may play some role in the regulation of BP in Japanese children.
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